HRC - histidine rich calcium binding protein Gene

中文名称：富组氨酸的钙结合蛋白

种属: Homo sapiens

基因 ID: 3270 | 基因类型: protein coding

关于 HRC

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,151,198-49,155,396 (from NCBI)

This gene has 4 transcripts (splice variants) and 87 orthologues. Restricted expression toward heart (RPKM 206.9).

功能概要

该基因编码一种管腔肌质网蛋白，该蛋白通过其以高亲和力结合低密度脂蛋白的能力来识别。该蛋白与 triadin 的细胞质结构域相互作用，triadin 是骨骼肌连接肌浆网 (SR) 的主要跨膜蛋白。该蛋白质在调节可释放的钙进入 SR 中发挥作用。[RefSeq 提供，2008 年 9 月]

This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. [provided by RefSeq, Sep 2008]

HRC 基因产物(1)

mRNA	Protein	Name
NM_002152.3	NP_002143.1	sarcoplasmic reticulum histidine-rich calcium-binding protein precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATPase binding	IPI IPI: 通过物理相互作用推断	17526652	GOA
enables calcium ion binding	IDA IDA: 通过直接分析推断	24125847	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	17526652	GOA
enables transmembrane transporter binding	IPI IPI: 通过物理相互作用推断	17526652	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of heart contraction	IGI IGI: 通过遗传相互作用推断	24125847	GOA
involved in positive regulation of heart rate	IGI IGI: 通过遗传相互作用推断	24125847	GOA
involved in positive regulation of relaxation of cardiac muscle	IGI IGI: 通过遗传相互作用推断	24125847	GOA
involved in regulation of calcium ion transmembrane transport	IGI IGI: 通过遗传相互作用推断	24125847	GOA
involved in regulation of cell communication by electrical coupling involved in cardiac conduction	IGI IGI: 通过遗传相互作用推断	24125847	GOA
involved in regulation of cytosolic calcium ion concentration	IGI IGI: 通过遗传相互作用推断	24125847	GOA
involved in regulation of heart rate	IMP IMP: 通过突变表型推断	18617481	GOA
involved in regulation of peptidyl-serine phosphorylation	IGI IGI: 通过遗传相互作用推断	24125847	GOA
involved in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IGI IGI: 通过遗传相互作用推断	24125847	GOA
involved in regulation of ryanodine-sensitive calcium-release channel activity	IGI IGI: 通过遗传相互作用推断	24125847	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Z disc	IDA IDA: 通过直接分析推断	24125847	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HRC 蛋白结构

Hist_rich_Ca-bd

0
200
400
600
699 a.a.

蛋白主名

其他名称

sarcoplasmic reticulum histidine-rich calcium-binding protein

HRC 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HRC	P23327	ZNF699	Homo sapiens	Q32M78	Y2H Prey Pooling	32296183
种属内	HRC	P23327	ZNF699	Homo sapiens	Q32M78	Y2H Array	32296183
种属内	HRC	P23327	ZNF699	Homo sapiens	Q32M78	Validated Y2H	32296183
种属间	HRC	P23327	Ryr2	Mus musculus	E9Q401	Confocal	24805197

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia	Arvc
Arvd	Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arvc Cardiomyopathy	Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia
Arvd/C	Right Ventricular Dysplasia, Arrhythmogenic
Ventricular Dysplasia, Right, Arrhythmogenic	Cardiomyopathy, Ventricular, Right, Arrhythmogenic
Dysplasia, Arrhythmogenic Right Ventricular

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06357	HRC Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	HRC	VGNC	VGNC:41783
Bos taurus	HRC	VGNC	VGNC:29952
Rattus norvegicus	HRC	RGD	RGD:727864
Macaca mulatta	HRC	VGNC	VGNC:73520
Mus musculus	HRC	MGD	MGI:96226
Others	HRC	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HRC - histidine rich calcium binding protein Gene

关于 HRC

功能概要

HRC 基因产物(1)

HRC 蛋白结构

HRC 蛋白互作信息

关联疾病

直系同源

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HRC - histidine rich calcium binding protein Gene

关于 HRC

功能概要

HRC 基因产物(1)

HRC 蛋白结构

HRC 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z