DNAJA1 - DnaJ heat shock protein family (Hsp40) member A1 Gene

中文名称：DnaJ 热休克蛋白家族 (Hsp40) 成员 A1

种属: Homo sapiens

同用名: DJ-2; DjA1; HDJ2; HSDJ; HSJ2; HSJ-2; HSPF4; NEDD7; hDJ-2

关于 DNAJA1

功能概要

该基因编码 DnaJ 蛋白家族的一个成员，该蛋白作为热休克蛋白 70 辅伴侣。热休克蛋白促进蛋白质折叠、运输、防止聚集和蛋白水解降解。该家族成员的特征是一个高度保守的 N 端 J 结构域、一个富含甘氨酸/苯丙氨酸的区域、四个 CxxCxGxG 锌指重复序列和一个 C 端底物结合结构域。 J 结构域介导与热休克蛋白 70 的相互作用以募集底物并调节 ATP 水解活性。在人类中，该基因通过甲型流感病毒的共同选择参与病毒复制的正调控。在其他染色体上发现了该基因的几个假基因。[RefSeq 提供，2015 年 9 月]

This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on Other chromosomes. [provided by RefSeq, Sep 2015]