1. Gene
  2. HSPA1A - heat shock protein family A (Hsp70) member 1A Gene

HSPA1A - heat shock protein family A (Hsp70) member 1A Gene

中文名称:热休克蛋白家族 A (Hsp70) 成员 1A

种属: Homo sapiens

同用名: HSP70; HSP72; HSPA1; HSP70I; HSP70-1; HSP70-2; HSP70.1; HSP70.2; HSP70-1A; HEL-S-103

基因 ID: 3303 | 基因类型: protein coding

关于 HSPA1A

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,815,543-31,817,942 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 142 orthologues and 13 paralogues.

功能概要

这个无内含子的基因编码一个 70kDa 的热休克蛋白,它是热休克蛋白 70 家族的一员。与其他热休克蛋白结合,该蛋白稳定现有蛋白以防止聚集,并介导新翻译蛋白在胞质溶胶和细胞器中的折叠。它还通过与富含 AU 的元素 RNA 结合蛋白 1 的相互作用参与泛素-蛋白酶体途径。该基因位于主要组织相容性复合体 III 类区域,与两个编码相似蛋白质的密切相关基因位于一个簇中。[RefSeq 提供,2008 年 7 月]

This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with Other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]

HSPA1A 基因产物(1)

mRNA Protein Name
NM_005345.6 NP_005336.3 heat shock 70 kDa protein 1A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
23921388 GOA
enables ATP hydrolysis activity IDA
IDA: 通过直接分析推断
21231916 GOA
enables ATP-dependent protein disaggregase activity IDA
IDA: 通过直接分析推断
23921388 GOA
enables C3HC4-type RING finger domain binding IPI
IPI: 通过物理相互作用推断
25281747 GOA
enables G protein-coupled receptor binding IDA
IDA: 通过直接分析推断
12150907 GOA
enables death receptor agonist activity IDA
IDA: 通过直接分析推断
26183779 GOA
enables denatured protein binding IPI
IPI: 通过物理相互作用推断
21909508 GOA
enables disordered domain specific binding IPI
IPI: 通过物理相互作用推断
11785981 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
23921388 GOA
enables heat shock protein binding IPI
IPI: 通过物理相互作用推断
23921388 GOA
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
16809764 GOA
enables misfolded protein binding IDA
IDA: 通过直接分析推断
28842558 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9222587 GOA
enables protein folding chaperone IDA
IDA: 通过直接分析推断
15603737 GOA
enables receptor ligand activity IDA
IDA: 通过直接分析推断
17568691 GOA
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
24790089 GOA
enables transcription corepressor activity IDA
IDA: 通过直接分析推断
9499401 GOA
enables transcription regulator inhibitor activity IDA
IDA: 通过直接分析推断
9499401 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
12150907 GOA
enables unfolded protein binding IDA
IDA: 通过直接分析推断
21231916 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ATP metabolic process IDA
IDA: 通过直接分析推断
23921388 GOA
involved in cellular heat acclimation IMP
IMP: 通过突变表型推断
21231916 GOA
involved in cellular response to heat IDA
IDA: 通过直接分析推断
9499401 GOA
involved in cellular response to unfolded protein IMP
IMP: 通过突变表型推断
20625543 GOA
involved in chaperone-mediated protein complex assembly IDA
IDA: 通过直接分析推断
10811660 GOA
involved in mRNA catabolic process IDA
IDA: 通过直接分析推断
10205060 GOA
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
17167422 GOA
involved in negative regulation of cell growth IMP
IMP: 通过突变表型推断
9553041 GOA
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
9553041 GOA
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
12150907 GOA
involved in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: 通过突变表型推断
17167422 GOA
involved in negative regulation of inclusion body assembly IDA
IDA: 通过直接分析推断
15603737 GOA
involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IDA
IDA: 通过直接分析推断
20625543 GOA
involved in negative regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
12150907 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9499401 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
24613385 GOA
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
24790089 GOA
involved in positive regulation of RNA splicing IDA
IDA: 通过直接分析推断
20625543 GOA
involved in positive regulation of endoribonuclease activity IDA
IDA: 通过直接分析推断
20625543 GOA
involved in positive regulation of erythrocyte differentiation IMP
IMP: 通过突变表型推断
17167422 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
25281747 GOA
involved in positive regulation of interleukin-8 production IMP
IMP: 通过突变表型推断
24790089 GOA
involved in positive regulation of microtubule nucleation IMP
IMP: 通过突变表型推断
27137183 GOA
involved in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
IMP: 通过突变表型推断
24790089 GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
24613385 GOA
involved in positive regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: 通过突变表型推断
24790089 GOA
involved in protein refolding IDA
IDA: 通过直接分析推断
15603737 GOA
involved in protein refolding IMP
IMP: 通过突变表型推断
27708256 GOA
involved in protein stabilization IDA
IDA: 通过直接分析推断
21909508 GOA
involved in protein stabilization IMP
IMP: 通过突变表型推断
24790089 GOA
involved in regulation of mitotic spindle assembly IMP
IMP: 通过突变表型推断
27137183 GOA
involved in regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
16809764 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of COP9 signalosome IDA
IDA: 通过直接分析推断
18850735 GOA
located in aggresome IDA
IDA: 通过直接分析推断
15885686 GOA
located in centriole IDA
IDA: 通过直接分析推断
24061851 GOA
located in centrosome IDA
IDA: 通过直接分析推断
27137183 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
9553041 GOA
located in cytosol IDA
IDA: 通过直接分析推断
21231916 GOA
is active in extracellular space IDA
IDA: 通过直接分析推断
17568691 GOA
located in inclusion body IDA
IDA: 通过直接分析推断
15603737 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
9553041 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10205060 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
10205060 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
23349634 GOA
part of ribonucleoprotein complex IDA
IDA: 通过直接分析推断
17289661 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HSPA1A 蛋白结构

HSP70

HSP70: Hsp70 protein (6 - 612)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 641 a.a.
蛋白主名 其他名称

heat shock 70 kDa protein 1A

HSP70-1/HSP70-2

HSPA1A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HSPA1A P0DMV8 HTT Homo sapiens P42858
Y2H Array
32814053
种属内
HSPA1A P0DMV8 HTT Homo sapiens P42858
Y2H Pooling
32814053
种属内
HSPA1A P0DMV8 HTT Homo sapiens P42858
Validated Y2H
32814053
种属内
HSPA1A P0DMV8 PSMD10 Homo sapiens O75832
Anti Tag CoIP
24338975
种属内
HSPA1A P0DMV8 POT1 Homo sapiens Q9NUX5
Pull Down
21044950
种属内
HSPA1A P0DMV8 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
种属内
HSPA1A P0DMV8 ATXN1 Homo sapiens P54253
Y2H Array
32814053
种属内
HSPA1A P0DMV8 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
种属间
HSPA1A P0DMV8 tetX Clostridium tetani P04958
Solid Phase Assay
24428437
种属间
HSPA1A P0DMV8 HA Influenza A virus P04663
Solid Phase Assay
24428437
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 HSPA1A 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73105 HSP70/HSPA1B Protein, Human (SF9, His) P0DMV9/NP_005337.2 (A2-D641) ≥95%
HY-P74877 HSP70/HSPA1A Protein, Human (HEK293, His) P0DMV8-1/NP_005336.3 (A2-D641) ≥95%
HY-P701004 HSP70/HSPA1A Protein, Human (E110D, His) P0DMV8-1 (A2-D641, E110D) ≥95%

关联疾病

疾病名称 别名
Transient Cerebral Ischemia

Transient Ischemic Attack

Transient Ischemic Attacks

Tia

Tia - Transient Ischaemic Attack

Transient Cerebral Ischaemia

Ischemic Attack, Transient

Intermittent Cerebral Ischemia

Tia - [Transient Ischaemic Attack]

Intermittent Cerebral Ischaemia

Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified

Ischemia

Acute Coronary Syndrome

Pulmonary Edema
Pneumoconiosis

Pneumoconioses

Silicosis Nos

Complicated Silicosis

Fibrosis Of Lung With Silicosis

Nodular Silicosis

Pneumoconiosis Due To Silica

Silicotic Fibrosis Of Lung

Simple Silicosis

Silicatosis

Silicotic Lung Fibrosis

Pneumoconiosis Due To Talc

Pulmonary Talcosis

Talc Lung Disease

Talc Pneumoconiosis

Talc Workers' Pneumoconiosis

Talcosis

Fibrosis Of Lung Due To Talc

Asbestos Pneumoconiosis

Amianthosis

Asbestosis

Lung Fibrosis With Asbestosis

Pulmonary Asbestosis

Diffuse Large B-Cell Lymphoma

Dlbcl

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Large B-Cell Diffuse Lymphoma

Lymphoma, Large B-Cell, Diffuse

Dlbcl - [Diffuse Large B-Cell Lymphoma]

Diffuse Large Beta Cell Lymphoma

Acute Kidney Failure

Acute Renal Failure

Acute Kidney Injury

Renal Failure Acute

Kidney Failure, Acute

Pre-Renal Acute Kidney Injury

Nontraumatic Acute Kidney Injury

Aki - [Acute Kidney Injury]

Arf - [Acute Kidney Failure]

Acute Kidney Disease

Acute Kidney Impairment

Acute Ischaemic Renal Failure

Acute Hypoxic Kidney Failure

Acute Kidney Shutdown

Acute Renal Oedema

Acute Renal Impairment

Acute Kidney Collapse

Acute Necrotising Kidney

Acute Renal Suppression

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus HSPA1A RGD RGD:1593284
Mus musculus HSPA1A MGD MGI:96244