HSPE1 - heat shock protein family E (Hsp10) member 1 Gene

中文名称：热休克蛋白家族 E (Hsp10) 成员 1

种属: Homo sapiens

同用名: EPF; CPN10; GROES; HSP10

基因 ID: 3336 | 基因类型: protein coding

关于 HSPE1

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:197,500,379-197,503,449 (from NCBI)

This gene has 7 transcripts (splice variants) and 159 orthologues. Ubiquitous expression in adrenal (RPKM 184.7), kidney (RPKM 90.5) and 24 other tissues.

功能概要

该基因编码一种主要的热休克蛋白，它起伴侣蛋白的作用。其结构由一个七聚体环组成，该环与另一种热休克蛋白结合以形成对称的功能性异二聚体，以 ATP 依赖性方式增强蛋白质折叠。该基因及其辅助伴侣蛋白 HSPD1 在 2 号染色体上以头对头的方向排列。自然发生的通读转录发生在该基因座和邻近基因座 MOBKL3 之间。[RefSeq 提供，2011 年 2 月]

This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011]

HSPE1 基因产物(1)

mRNA	Protein	Name
NM_002157.3	NP_002148.1	10 kDa heat shock protein, mitochondrial

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	9989505	GOA
enables protein-folding chaperone binding	IPI IPI: 通过物理相互作用推断	10205158	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in mitochondrion	IDA IDA: 通过直接分析推断	10205158	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HSPE1 蛋白结构

Cpn10

0
102 a.a.

蛋白主名

其他名称

10 kDa heat shock protein, mitochondrial

10 kDa chaperonin

HSPE1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HSPE1	P61604	SELENOM	Homo sapiens	Q8WWX9	Validated Y2H	32296183
种属内	HSPE1	P61604	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 HSPE1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76283	HSP10/EPF Protein, Human (His)	P61604 (M1-D102)	≥95%

HSPE1 抗体

目录号	产品名	应用	反应物种
HY-P82445	Cpn10 Antibody (YA2190)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Exocervical Carcinoma

Carcinoma Of Exocervix

Carcinoma Of The Exocervix

Leukodystrophy, Hypomyelinating, 4

Mitochondrial Hsp60 Chaperonopathy	Hypomyelinating Leukodystrophy 4
HLD4	Mitchap60 Disease
Pelizaeus-Merzbacher-Like Disease Due To Hspd1 Mutation	Mitchap-60 Disease
Leukodystrophy, Hypomyelinating, Type 4

Sennetsu Fever

Sennetsu Ehrlichiosis

Human Ehrlichial Infection, Sennetsu Type

Mycobacterium Tuberculosis 1

Tuberculosis	Tuberculoma
Tuberculosis, Susceptibility To	Mycobacterium Tuberculosis, Susceptibility To, 1
Mtbs1	TB

Purulent Labyrinthitis

Suppurative Labyrinthitis	Acute Suppurative Labyrinthitis
Bacterial Labyrinthitis

Spastic Paraplegia 13, Autosomal Dominant

SPG13	Hereditary Spastic Paraplegia 13
Autosomal Dominant Spastic Paraplegia 13	Spastic Paraplegia 13
Autosomal Dominant Spastic Paraplegia Type 13	Spastic Paraplegia-13
Paraplegia, Spastic, Type 13

Chlamydia

Chlamydial Infection	Chlamydia Trachomatis Infectious Disease
Chlamydial Disease	Chlamydia Infections

Carrion'S Disease

Oroya Fever	Carrion Disease
Bartonellosis Due To Bartonella Bacilliformis Infection	Bartonella Infections
Systemic Bartonellosis Due To Bartonella Bacilliformis	Systemic Carrión Disease
Systemic Bartonellosis	Bartonella Fever

Placental Abruption

Abruptio Placentae	Abruptio Placenta
Abortion, Threatened	Threatened Miscarriage
Haemorrhage Specified As Due To Threatened Abortion	Spontaneous Threatened Abortion

Skeletal Tuberculosis

Tuberculosis, Osteoarticular

Osteoarticular Tuberculosis

Bejel

Njovera	Dichuchwa
Nonvenereal Endemic Syphilis	Endemic Syphilis
Frenga	Nonvenereal Syphilis
Treponemal Infections	Non-Venereal Endemic Syphilis
Siti	Skerljevo
Belesh

Epidemic Typhus

Typhus	Typhus Fever
Epidemic Louse-Borne Typhus Fever Due To Rickettsia Prowazekii	Murine Typhus
Classical Typhus	Endemic Flea-Borne Typhus
Endemic Typhus Fever	Epidemic Louse-Borne Typhus
Famine Fever	Flea-Borne Typhus
Jail Fever	Louse-Borne Typhus
Mexican Typhus	Shop Typhus
Urban Typhus	Brill-Zinsser Disease
Endemic Typhus	Sylvatic Typhus
Epidemic Typhus	European Typhus
Exanthematic Typhus Fever	Exanthematous Typhus
Flea Typhus	Flea-Borne Rickettsiosis
Hospital Fever	Louse-Borne [Epidemic] Typhus
Louse-Borne Rickettsiosis	Moscow Typhus
Murine [Endemic] Typhus	Petechial Fever
Prison Fever	Rat Flea Typhus
Ship Fever	Typhus Exanthematique
Typhus, Endemic Flea-Borne	Typhus, Epidemic Louse-Borne
Typhus Group Rickettsial Disease	Relapsing Fever
Typhus Fever Nos	Typhus Nos
Epidemic Typhus Fever	Louse-Borne Typhus Fever
Classical Typhus Fever	Louse-Borne Tabardillo
Epidemic Typhus Fever Due To Rickettsia Prowazekii	Endemic Murine Typhus
Flea-Borne Typhus Fever	Murine Endemic Flea Typhus
Rat Typhus	Typhus Due To Rickettsia Typhi
Flea-Borne Tabardillo	Rickettsia Typhi Rickettsiosis
Mexican Fever	Murine Flea-Borne Typhus
Mooser Bodies	Tsutsugamushi Fever
Kedani Fever	Mite-Borne Typhus
Mite-Borne Typhus Due To Rickettsia Tsutsugamushi	Scrub Typhus
Tsutsugamushi	Tsutsugamushi Disease
Scrub Mite-Borne Typhus	Sumatran Mite Fever
Japanese River Fever	Kedani Typhus
Rickettsia Tsutsugamushi Rickettsiosis	Sumatran Mite Typhus
Tropical Typhus	Japanese Typhus

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Pontiac Fever

Lung Abscess

Apical Lung Abscess	Abscess Of Lung
Abscess Of Lung Nos	Pulmonary Abscess
Multiple Abscess Of Lung

Tularemia

Francisella Tularensis Infection	Deerfly Fever
Lemming Fever	Ohara Disease
Pahvant Valley Plague	Rabbit Fever
Yatobyo

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Congenital Central Hypoventilation Syndrome

Cchs	Haddad Syndrome
Ondine Curse	Ondine Syndrome
Congenital Central Hypoventilation	Congenital Central Alveolar Hypoventilation Syndrome
Congenital Failure Of Autonomic Control	Ondine'S Curse
Primary Alveolar Hypoventilation	Ondine-Hirschsprung Disease
Central Congenital Hypoventilation Syndrome	Congenital Ondine Curse
Idiopathic Congenital Central Alveolar Hypoventilation	Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome
Ondine-Hirschsprung Syndrome

Hypomyelinating Leukodystrophy

Hld	Leukodystrophy, Hypomyelinating

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06448	HSPE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	HSPE1	RGD	RGD:2844
Bos taurus	HSPE1	VGNC	VGNC:49071
Felis catus	HSPE1	VGNC	VGNC:80237
Mus musculus	HSPE1	MGD	MGI:104680
Others	HSPE1	NCBI

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