2. Gene
  3. HTR5A - 5-hydroxytryptamine receptor 5A Gene

HTR5A - 5-hydroxytryptamine receptor 5A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：5-羟色胺受体 5A

种属: Homo sapiens

同用名: 5-HT5A

基因 ID: 3361 | 基因类型: protein coding

关于 HTR5A

Cytogenetic location: 7q36.2 Genomic coordinates (GRCh38): 7:155,070,324-155,087,392 (from NCBI)

This gene has 3 transcripts (splice variants), 215 orthologues and 8 paralogues. Restricted expression toward brain (RPKM 2.3).

功能概要

神经递质血清素 (5-羟色胺，5-HT) 与多种精神疾病有关，并且还具有血管收缩和血管舒张作用。该记录中描述的基因是 5-羟色胺 (5-羟色胺) 受体家族的成员，编码一种多通道膜蛋白，该蛋白作为 5-羟色胺的受体并与 G 蛋白偶联。该蛋白质已显示部分通过调节细胞内 Ca2+ 动员发挥作用。[RefSeq 提供，2008 年 7 月]

The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]

HTR5A 基因产物(1)

mRNA Protein Name
NM_024012.4 NP_076917.1 5-hydroxytryptamine receptor 5A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled serotonin receptor activity IDA
IDA: 通过直接分析推断
7988681 GOA
enables Gi/o-coupled serotonin receptor activity IDA
IDA: 通过直接分析推断
9865521 GOA
enables serotonin receptor activity IDA
IDA: 通过直接分析推断
9865521 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA
IDA: 通过直接分析推断
9865521 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in plasma membrane IDA
IDA: 通过直接分析推断
9865521 GOA
is active in plasma membrane IMP
IMP: 通过突变表型推断
9865521 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HTR5A 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (58 - 338)

  • 0
  • 100
  • 200
  • 300
  • 357 a.a.
蛋白主名 其他名称

5-hydroxytryptamine receptor 5A

5-HT-5

5-HT-5A

5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled

关联疾病

疾病名称 别名
Sacral Defect With Anterior Meningocele

Caudal Regression Syndrome

Caudal Regression Sequence

Sacral Agenesis

Caudal Dysgenesis Syndrome

SDAM

Caudal Dysplasia Sequence

Caudal Dysplasia

Sacral Agenesis Syndrome

Sacral Regression Syndrome

Sacral Defect And Anterior Sacral Meningocele

Rudd Klimek Syndrome

Sirenomelia
Ciliary Dyskinesia, Primary, 19

Primary Ciliary Dyskinesia 19

CILD19

Primary Ciliary Dyskinesia 19 With Or Without Situs Inversus

Ciliary Dyskinesia, Primary, 19, With Or Without Situs Inversus

Ics19

Immotile Cilia Syndrome 19

Dyskinesia, Ciliary, Primary, 19
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06477 HTR5A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06478 Htr5a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06479 Htr5a Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus HTR5A MGD MGI:96283
Canis familiaris HTR5A VGNC VGNC:41832
Bos taurus HTR5A VGNC VGNC:30001
Macaca mulatta HTR5A VGNC VGNC:73545
Felis catus HTR5A VGNC VGNC:102598
Rattus norvegicus HTR5A RGD RGD:2851
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