1. Gene
  2. APOA4 - apolipoprotein A4 Gene

APOA4 - apolipoprotein A4 Gene

中文名称:载脂蛋白 A4

种属: Homo sapiens

基因 ID: 337 | 基因类型: protein coding

关于 APOA4

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:116,820,700-116,823,304 (from NCBI)

This gene has 1 transcript (splice variant), 116 orthologues and 3 paralogues. Restricted expression toward small intestine (RPKM 1486.2).

功能概要

载脂蛋白 (apo) A-IV 基因包含 3 个外显子,由两个内含子隔开。在第三个外显子的 3'UTR 中发现了序列多态性。主要翻译产物是一种含有 396 个残基的前体蛋白,在蛋白水解加工后,它与乳糜微粒结合,分泌出其主要合成部位,即肠。虽然其确切功能尚不清楚,但 apo A-IV 在体外是卵磷脂-胆固醇酰基转移酶的有效激活剂。[RefSeq 提供,2008 年 7 月]

Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol Acyltransferase in vitro. [provided by RefSeq, Jul 2008]

APOA4 基因产物(1)

mRNA Protein Name
NM_000482.4 NP_000473.2 apolipoprotein A-IV precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables antioxidant activity IDA
IDA: 通过直接分析推断
16945374 GOA
enables cholesterol transfer activity IDA
IDA: 通过直接分析推断
1935934 GOA
enables copper ion binding IDA
IDA: 通过直接分析推断
16945374 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
22579246 GOA
enables lipid binding IMP
IMP: 通过突变表型推断
16159879 GOA
enables phosphatidylcholine binding IDA
IDA: 通过直接分析推断
1935934 GOA
enables phosphatidylcholine-sterol O-acyltransferase activator activity IDA
IDA: 通过直接分析推断
1935934 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24311788 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
1935934 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cholesterol efflux IDA
IDA: 通过直接分析推断
1935934 GOA
involved in cholesterol homeostasis IDA
IDA: 通过直接分析推断
1935934 GOA
involved in cholesterol metabolic process IDA
IDA: 通过直接分析推断
1935934 GOA
involved in high-density lipoprotein particle remodeling IDA
IDA: 通过直接分析推断
1935934 GOA
involved in hydrogen peroxide catabolic process IDA
IDA: 通过直接分析推断
16945374 GOA
involved in innate immune response in mucosa IDA
IDA: 通过直接分析推断
15254593 GOA
involved in leukocyte cell-cell adhesion IDA
IDA: 通过直接分析推断
15254593 GOA
involved in lipid catabolic process IDA
IDA: 通过直接分析推断
3095477 GOA
involved in lipid homeostasis IDA
IDA: 通过直接分析推断
3095477 GOA
involved in lipid transport IDA
IDA: 通过直接分析推断
1935934 GOA
involved in negative regulation of plasma lipoprotein oxidation IDA
IDA: 通过直接分析推断
16945374 GOA
involved in phosphatidylcholine metabolic process IDA
IDA: 通过直接分析推断
1935934 GOA
involved in phospholipid efflux IDA
IDA: 通过直接分析推断
11162594 GOA
involved in positive regulation of CoA-transferase activity IDA
IDA: 通过直接分析推断
1935934 GOA
involved in positive regulation of fatty acid biosynthetic process IDA
IDA: 通过直接分析推断
2307668 GOA
involved in positive regulation of lipoprotein lipase activity IDA
IDA: 通过直接分析推断
2307668 GOA
involved in positive regulation of triglyceride catabolic process IDA
IDA: 通过直接分析推断
2307668 GOA
involved in protein-lipid complex assembly IMP
IMP: 通过突变表型推断
16159879 GOA
involved in regulation of cholesterol transport IDA
IDA: 通过直接分析推断
11940599 GOA
involved in removal of superoxide radicals IDA
IDA: 通过直接分析推断
16945374 GOA
involved in response to lipid hydroperoxide IDA
IDA: 通过直接分析推断
16945374 GOA
involved in reverse cholesterol transport IDA
IDA: 通过直接分析推断
3095477 GOA
involved in very-low-density lipoprotein particle remodeling IDA
IDA: 通过直接分析推断
2307668 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with cell surface IDA
IDA: 通过直接分析推断
1935934 GOA
part of chylomicron IDA
IDA: 通过直接分析推断
3095477 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
1935934 GOA
part of high-density lipoprotein particle IDA
IDA: 通过直接分析推断
3095477 GOA
part of very-low-density lipoprotein particle IDA
IDA: 通过直接分析推断
3095477 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

APOA4 蛋白结构

Apolipoprotein

Apolipoprotein: Apolipoprotein A1/A4/E domain (61 - 242)

Apolipoprotein

Apolipoprotein: Apolipoprotein A1/A4/E domain (238 - 388)

  • 0
  • 100
  • 200
  • 300
  • 396 a.a.
蛋白主名 其他名称

apolipoprotein A-IV

apo-AIV

APOA4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
APOA4 P06727 MAGEA6 Homo sapiens P43360 32296183
种属内
APOA4 P06727 MAGEA6 Homo sapiens P43360 32296183
种属内
APOA4 P06727 MAGEA6 Homo sapiens P43360 32296183
种属内
APOA4 P06727 AGTRAP Homo sapiens Q6RW13-2 32296183
种属内
APOA4 P06727 AGTRAP Homo sapiens Q6RW13-2 32296183
种属内
APOA4 P06727 AGTRAP Homo sapiens Q6RW13-2 32296183
种属内
APOA4 P06727 CMTM5 Homo sapiens Q96DZ9-2 32296183
种属内
APOA4 P06727 CMTM5 Homo sapiens Q96DZ9-2 32296183
种属内
APOA4 P06727 CMTM5 Homo sapiens Q96DZ9-2 32296183
种属内
APOA4 P06727 APOA4 Homo sapiens P06727 22579246
种属内
APOA4 P06727 CMTM4 Homo sapiens Q8IZR5-2 32296183
种属内
APOA4 P06727 APOA4 Homo sapiens P06727
GMS
22579246
种属内
APOA4 P06727 CMTM4 Homo sapiens Q8IZR5-2 32296183
种属内
APOA4 P06727 APOA4 Homo sapiens P06727 22579246
种属内
APOA4 P06727 CMTM4 Homo sapiens Q8IZR5-2 32296183
种属内
APOA4 P06727 APOA4 Homo sapiens P06727 22579246
种属内
APOA4 P06727 APOA4 Homo sapiens P06727 22579246
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 APOA4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7528 ApoA-IV Protein, Human (HEK293, His) P06727 (E21-S396) ≥95%

APOA4 抗体

目录号 产品名 应用 反应物种
HY-P82847 ApoA4 Antibody (YA2592) WB, IP Human

关联疾病

疾病名称 别名
Familial Hyperlipidemia

Familial Hyperlipoproteinemia

Hyperlipidaemia

Hyperlipoproteinemias

Hyperlipidemia

Hyperlipemia

Hyperlipidemias

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia

Familial Hyperbetalipoproteinaemia

Familial Hypercholesteremia

Fredrickson Type Iia Hyperlipoproteinemia

Fredrickson Type Iia Lipidaemia

Hyperbetalipoproteinemia

Type Ii Hyperlipidemia

Familial Hypercholesterolæmia

Familial Hypercholesterolaemia

Fh

Hypercholesterolemia Familial

Hyperlipoproteinemia Type Ii

Hypercholesterolemia, Familial

Carotenemia

Hypercarotinemia

Amyloidosis, Familial Visceral

Ostertag Type Amyloidosis

German Type Amyloidosis

Familial Renal Amyloidosis

Amyloidosis Viii

Amyloidosis, 3 Or More Types

Familial Visceral Amyloidosis

Familial Amyloid Nephropathy

Hereditary Amyloid Nephropathy

Amyloidosis, Familial Renal

Amyloidosis, Systemic Nonneuropathic

Amyloidosis Familial Visceral

Amyloidosis 8

Amyloidosis, Ostertag Type

Hereditary Amyloidosis With Primary Renal Involvement

Hereditary Renal Amyloidosis

Renal Amyloidosis

Amyloidosis, Renal

Systemic Nonneuropathic Amyloidosis

Amyloidosis Familial Renal

Amyloidosis Systemic Nonneuropathic

Hereditary Amyloidosis With Primary Renal Involement

AMYL8

Systemic Non-Neuropathic Amyloidosis

Amyloid Nephropathy

Apolipoprotein A-Iv Associated Amyloidosis

Aapoaiv Amyloidosis

Renal Aapoaiv Amyloidosis

Apolipoprotein A-Iv Amyloidosis

Thrombophilia Due To Hrg Deficiency

Hereditary Thrombophilia Due To Congenital Histidine-Rich Glycoprotein Deficiency

Hereditary Thrombophilia Due To Congenital Hrg Deficiency

Thph11

Hyperlipidemia, Familial Combined, 3

Familial Combined Hyperlipidemia

Combined Hyperlipidemia, Familial

Mixed Hyperlipidaemia

FCHL3

Hyperlipidemia, Familial Combined

Familial Multiple Lipoprotein-Type Hyperlipidemia

Hyperbetalipoproteinemia With Prebetalipoproteinemia

Type Iib Hyperlipoproteinemia

Hyperlipidemia Familial Combined

Hyperlipoproteinemia Type Iib

Mixed Hyperlipemia

Hyperlipidaemia, Group C

Familial Hypercholesterolaemia With Hyperlipaemia

Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia

Hyperbetalipoproteinaemia With Prebetalipoproteinaemia

Hypercholesterolaemia With Endogenous Hyperglyceridaemia

Prebetalipoproteinemia Hyperbetalipoproteinaemia

Remnant Hyperlipoproteinemia

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Chylomicron Retention Disease

CMRD

Anderson Disease

Lipid Transport Defect Of Intestine

Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells

Andd

Anderson Syndrome

Crd

Andersons Disease

Malabsorption Syndrome

Hypoalphalipoproteinemia, Primary, 2

Apolipoprotein A-I Deficiency

Hypoalphalipoproteinemia, Primary, 2, Autosomal Recessive

Primary Hypoalphalipoproteinemia 2

High Density Lipoprotein Deficiency

Apoa-I Deficiency

Familial Apoa-I Deficiency

Familial Hypoalphalipoproteinemia

FHA2

Apolipoprotein A-I

Kidney Disease

Renal Failure

Kidney Failure

Kidney Diseases

Nephropathy

Abnormality Of The Kidney

Impaired Renal Function Disease

Renal Anomaly

Kidney Dysfunction

Renal Disease

Nephropathies

Renal Failure Adverse Event

Abnormal Renal Function

Diabetes Mellitus

Diabetes

Myocardial Infarction

Heart Attack

Myocardial Infarction, Susceptibility To

Myocardial Infarction 1

Myocardial Infarction, Protection Against

Myocardial Infarction, Decreased Susceptibility To

Myocardial Infarction, Decreased

Myocardial Infarct

MCI1

Premature Myocardial Infarction

Myocardial Infarction, Susceptibility To, Type 1

Cardiovascular System Disease

Abnormality Of The Cardiovascular System

Cardiovascular Disease

Disease Of Subdivision Of Hemolymphoid System

Disorder Of Cardiovascular System

Cardiovascular Diseases

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

Glycogen Storage Disease

Glycogenosis

Glycogenoses

Gsd

Storage Disease, Glycogen

Gsd - [Glycogen Storage Disease]

Glycogen Thesaurismosis

Diffuse Glycogenosis

Generalised Glycogen Storage Disease

Generalised Glycogenosis

Generalised Glycogen Storage Disease Of Infants

Glycogen Synthase Deficiency

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Anomaly

Coronary Artery Disease, Susceptibility To

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus APOA4 MGD MGI:88051
Felis catus APOA4 VGNC VGNC:81902
Rattus norvegicus APOA4 RGD RGD:2132
Macaca mulatta APOA4 VGNC VGNC:82104
Bos taurus APOA4 VGNC VGNC:26024
Canis familiaris APOA4 VGNC VGNC:53263
Others APOA4 NCBI