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  3. TREML1 - triggering receptor expressed on myeloid cells like 1 Gene

TREML1 - triggering receptor expressed on myeloid cells like 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：在骨髓细胞上表达的触发受体样 1

种属: Homo sapiens

同用名: TLT1; TLT-1; PRO3438; GLTL1825; dJ238O23.3

基因 ID: 340205 | 基因类型: protein coding

关于 TREML1

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,149,260-41,155,403 (from NCBI)

This gene has 4 transcripts (splice variants), 95 orthologues and 13 paralogues. Biased expression in bone marrow (RPKM 1.9), lymph node (RPKM 1.7) and 10 other tissues.

功能概要

该基因编码在髓系细胞样 (TREM) 家族上表达的触发受体的成员。编码的蛋白质是一种 1 型单 Ig 结构域孤儿受体，定位于血小板的 α 颗粒膜。编码的蛋白质参与血小板聚集、炎症和细胞活化，并与格雷血小板综合征有关。可变剪接导致多个转录变体[RefSeq 提供，2012 年 11 月]

This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain Orphan Receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]

TREML1 基因产物(3)

mRNA Protein Name
NM_001271807.1 NP_001258736.1 trem-like transcript 1 protein isoform b precursor
NM_001271808.1 NP_001258737.1 trem-like transcript 1 protein isoform c precursor
NM_178174.4 NP_835468.1 trem-like transcript 1 protein isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15128762 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in calcium-mediated signaling IDA
IDA: 通过直接分析推断
15128762 GOA
involved in platelet activation IEP
IEP: 通过表达模式推断
15128762 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
15128762 GOA
located in platelet alpha granule IDA
IDA: 通过直接分析推断
15128762 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TREML1 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (22 - 109)

  • 0
  • 100
  • 200
  • 311 a.a.
蛋白主名 其他名称

trem-like transcript 1 protein

triggering receptor expressed on myeloid cells-like protein 1

重组 TREML1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71382 TREML1 Protein, Human (147a.a, HEK293, His) Q86YW5 (Q16-P162) ≥95%
HY-P701054 TREML1 Protein, Human (147a.a, HEK293, hFc) Q86YW5/XP_016866312.1 (Q16-P162) ≥95%

关联疾病

疾病名称 别名
Gray Platelet Syndrome

Platelet Alpha-Granule Deficiency

GPS

Bdplt4

Bleeding Disorder, Platelet-Type, 4

Grey Platelet Syndrome

Platelet-Type Bleeding Disorder 4

Marked Decrease Or Absence Of Alpha-Granules And Of Platelet-Specific Alpha-Granule Proteins

Deficient Alpha Granule Syndrome

Platelet Alpha Granule Deficiency

Platelet Granule Defect

Alpha Storage Pool Deficiency

Bleeding Disorder Platelet-Type 4
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

Plosl

Nhd

Presenile Dementia With Bone Cysts

Plo-Sl

PLOSL1

Dementia, Prefrontal, With Bone Cysts

Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease

Progressive Dementia With Lipomembranous Polycystic Osteodysplasia

Brain-Bone-Fat Disease
Shwartzman Phenomenon

Shwartzman Reaction
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15004 TREML1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TREML1 RGD RGD:1565175
Macaca mulatta TREML1 VGNC VGNC:79250
Mus musculus TREML1 MGD MGI:1918576
Bos taurus TREML1 VGNC VGNC:36300
Felis catus TREML1 VGNC VGNC:66520
Others TREML1 NCBI
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