2. Gene
  3. STAC2 - SH3 and cysteine rich domain 2 Gene

STAC2 - SH3 and cysteine rich domain 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SH3 和富半胱氨酸的结构域 2

种属: Homo sapiens

同用名: 24b2; 24b2/STAC2

基因 ID: 342667 | 基因类型: protein coding

关于 STAC2

This gene has 2 transcripts (splice variants), 238 orthologues and 2 paralogues. Biased expression in brain (RPKM 11.7), kidney (RPKM 2.2) and 3 other tissues.

功能概要

该基因编码的蛋白质包含一个 SH3 结构域和一个锌指结构域。编码的蛋白质已被证明可以调节人类细胞系中的钙通道失活。已在人类心力衰竭中观察到该基因表达减少。[RefSeq 提供，2017 年 5 月]

This gene encodes a protein containing an SH3 domain and a zinc finger domain. The encoded protein has been shown to regulate Calcium Channel inactivation in a human cell line. Reduced expression of this gene has been observed in human heart failure. [provided by RefSeq, May 2017]

STAC2 基因产物(2)

mRNA Protein Name
NM_001351360.2 NP_001338289.1 SH3 and cysteine-rich domain-containing protein 2 isoform 2
NM_198993.5 NP_945344.1 SH3 and cysteine-rich domain-containing protein 2 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16713569 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STAC2 蛋白结构

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (111 - 157)

SH3_9

SH3_9: Variant SH3 domain (299 - 347)

  • 0
  • 100
  • 200
  • 300
  • 411 a.a.
蛋白主名 其他名称

SH3 and cysteine-rich domain-containing protein 2

SRC homology 3 and cysteine-rich domain-containing protein 2

STAC2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
STAC2 Q6ZMT1 LNX1 Homo sapiens Q8TBB1
Validated Y2H
25416956
种属内
STAC2 Q6ZMT1 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
25416956
种属内
STAC2 Q6ZMT1 ATXN1 Homo sapiens P54253
Y2H
16713569
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Childhood-Onset Schizophrenia

Childhood Schizophrenia

Schizophrenia, Childhood
Myopathy, Congenital, Bailey-Bloch

Native American Myopathy

Nam

MYPBB

Myopathy, Congenital, Baily-Bloch

Anti-Hmg-Coa Myopathy

Anti-Srp Myopathy

Autoimmune Necrotizing Myositis

Imnm

Immune Myopathy With Myocyte Necrosis

Immune-Mediated Necrotizing Myopathy

Myopathy, Congenital, With Myopathic Facies, Scoliosis, And Malignant Hyperthermia

Necrotizing Autoimmune Myopathy

Congenital Myopathy-Cleft Palate-Malignant Hyperthermia Syndrome

Congenital Myopathy With Cleft Palate And Malignant Hyperthermia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13864 STAC2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus STAC2 MGD MGI:2144518
Felis catus STAC2 VGNC VGNC:65742
Canis familiaris STAC2 VGNC VGNC:46871
Bos taurus STAC2 VGNC VGNC:35351
Rattus norvegicus STAC2 RGD RGD:1305548
Macaca mulatta STAC2 VGNC VGNC:77979
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