2. Gene
  3. IFI35 - interferon induced protein 35 Gene

IFI35 - interferon induced protein 35 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：干扰素诱导蛋白 35

种属: Homo sapiens

同用名: IFP35

基因 ID: 3430 | 基因类型: protein coding

关于 IFI35

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:43,006,784-43,014,456 (from NCBI)

This gene has 8 transcripts (splice variants), 200 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 18.2), appendix (RPKM 14.5) and 25 other tissues.

功能概要

实现相同的蛋白质结合活性。参与多个过程，包括参与免疫反应的巨噬细胞激活；积极调节防御反应；和信号转导的调节。位于几种细胞成分中，包括细胞质；细胞外空间；和核。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity. Involved in several processes, including macrophage activation involved in immune response; positive regulation of defense response; and regulation of signal transduction. Located in several cellular components, including cytosol; extracellular space; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

IFI35 基因产物(2)

mRNA Protein Name
NM_001330230.2 NP_001317159.1 interferon-induced 35 kDa protein isoform 2
NM_005533.5 NP_005524.2 interferon-induced 35 kDa protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IDA
IDA: 通过直接分析推断
10950963 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8954125 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in macrophage activation involved in immune response IDA
IDA: 通过直接分析推断
29038465 GOA
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
29350881 GOA
involved in negative regulation of non-canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
29350881 GOA
involved in positive regulation of inflammatory response IDA
IDA: 通过直接分析推断
29038465 GOA
involved in positive regulation of innate immune response IDA
IDA: 通过直接分析推断
29038465 GOA
involved in positive regulation of toll-like receptor 4 signaling pathway IDA
IDA: 通过直接分析推断
29038465 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10950963 GOA
located in cytosol IDA
IDA: 通过直接分析推断
10779520 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
29038465 GOA
located in membrane IDA
IDA: 通过直接分析推断
10950963 GOA
located in nucleus IDA
IDA: 通过直接分析推断
8288566 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IFI35 蛋白结构

IFP_35_N

IFP_35_N: Interferon-induced 35 kDa protein (IFP 35) N-terminus (9 - 80)

NID

NID: Nmi/IFP 35 domain (NID) (81 - 170)

NID

NID: Nmi/IFP 35 domain (NID) (181 - 266)

  • 0
  • 100
  • 200
  • 286 a.a.
蛋白主名 其他名称

interferon-induced 35 kDa protein

IFP 35

IFI35 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
IFI35 P80217 CLEC4G Homo sapiens Q6UXB4
Confocal
18624398
种属内
IFI35 P80217 CLEC4G Homo sapiens Q6UXB4
Anti Tag CoIP
18624398
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Stomatitis
Mouth Disease

Mouth Diseases

Mouth Disorders
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06555 IFI35 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus IFI35 MGD MGI:1917360
Rattus norvegicus IFI35 RGD RGD:1304553
Bos taurus IFI35 VGNC VGNC:30044
Canis familiaris IFI35 VGNC VGNC:41872
Felis catus IFI35 VGNC VGNC:67697
Macaca mulatta IFI35 VGNC VGNC:73564
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