IFNAR2 - interferon alpha and beta receptor subunit 2 Gene

中文名称：干扰素 α 和 β 受体亚基 2

种属: Homo sapiens

同用名: IFN-R; IMD45; IFNABR; IFNARB; IFN-alpha-REC

基因 ID: 3455 | 基因类型: protein coding

关于 IFNAR2

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:33,229,938-33,265,664 (from NCBI)

This gene has 14 transcripts (splice variants), 303 orthologues, 11 paralogues and is associated with 3 phenotypes. Ubiquitous expression in spleen (RPKM 13.0), appendix (RPKM 12.7) and 24 other tissues.

功能概要

由该基因编码的蛋白质是一种 I 型膜蛋白，它形成干扰素 α 和 β 受体的两条链之一。受体的结合和激活会刺激 Janus 蛋白激酶，进而磷酸化多种蛋白质，包括 STAT1 和 STAT2。该蛋白属于 II 型细胞因子受体家族。该基因的突变与免疫缺陷 45 相关。[RefSeq 提供，2020 年 7 月]

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45. [provided by RefSeq, Jul 2020]

IFNAR2 基因产物(8)

mRNA	Protein	Name
NM_000874.5	NP_000865.2	interferon alpha/beta receptor 2 isoform b
NM_001385055.1	NP_001371984.1	interferon alpha/beta receptor 2 isoform e
NM_001385054.1	NP_001371983.1	interferon alpha/beta receptor 2 isoform d
NM_001289128.2	NP_001276057.1	interferon alpha/beta receptor 2 isoform c
NM_207584.3	NP_997467.1	interferon alpha/beta receptor 2 isoform b
NM_207585.3	NP_997468.1	interferon alpha/beta receptor 2 isoform a
NM_001289125.3	NP_001276054.1	interferon alpha/beta receptor 2 isoform a
NM_001289126.2	NP_001276055.1	interferon alpha/beta receptor 2 isoform c

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cytokine binding	IPI IPI: 通过物理相互作用推断	8798579	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	7665574	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	7759950	GOA
enables type I interferon binding	IPI IPI: 通过物理相互作用推断	7759950	GOA
enables type I interferon receptor activity	IDA IDA: 通过直接分析推断	7665574	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell surface receptor signaling pathway via JAK-STAT	IDA IDA: 通过直接分析推断	7759950	GOA
involved in cellular response to interferon-beta	IDA IDA: 通过直接分析推断	7759950	GOA
involved in defense response to virus	IMP IMP: 通过突变表型推断	26424569	GOA
involved in response to interferon-alpha	IDA IDA: 通过直接分析推断	7759950	GOA
involved in response to interferon-alpha	IMP IMP: 通过突变表型推断	26424569	GOA
involved in response to interferon-beta	IDA IDA: 通过直接分析推断	7759950	GOA
involved in response to interferon-beta	IMP IMP: 通过突变表型推断	26424569	GOA
involved in type I interferon-mediated signaling pathway	IDA IDA: 通过直接分析推断	7665574	GOA
involved in type I interferon-mediated signaling pathway	IMP IMP: 通过突变表型推断	26424569	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	7759950	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	7759950	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IFNAR2 蛋白结构

Tissue_fac

Interfer-bind

0
100
200
300
400
515 a.a.

蛋白主名

其他名称

interferon alpha/beta receptor 2

IFN-R-2	IFN-alpha/beta receptor 2
IFNalpha/beta receptor subunit 2	human interferon alpha/beta receptor
interferon (alpha, beta and omega) receptor 2	interferon alpha binding protein
interferon receptor	interferon-alpha/beta receptor beta chain
type I interferon receptor 2

IFNAR2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	IFNAR2	P48551	STAT1	Homo sapiens	P42224	Pull Down	9121453
种属内	IFNAR2	P48551	JAK1	Homo sapiens	P23458	Anti Tag CoIP	16710296
种属内	IFNAR2	P48551	JAK1	Homo sapiens	P23458	Pull Down	16710296
种属内	IFNAR2	P48551	STAT2	Homo sapiens	P52630	Pull Down	9121453
种属内	IFNAR2	P48551	STAT2	Homo sapiens	P52630	Anti Bait CoIP	17923090
种属内	IFNAR2	P48551	STAT2	Homo sapiens	P52630	Anti Tag CoIP	17923090
种属内	IFNAR2	P48551	RACK1	Homo sapiens	P63244	Y2H	11046044
种属内	IFNAR2	P48551	RACK1	Homo sapiens	P63244	Pull Down	11046044
种属内	IFNAR2	P48551	USP18	Homo sapiens	Q9UMW8	Anti Tag CoIP	16710296
种属内	IFNAR2	P48551	IFNA2	Homo sapiens	P01563	X-Ray Diffraction	21854986
种属内	IFNAR2	P48551	IRF9	Homo sapiens	Q00978	Anti Bait CoIP	17923090
种属内	IFNAR2	P48551	IRF9	Homo sapiens	Q00978	Far-WB	17923090
种属内	IFNAR2	P48551	PDLIM1	Homo sapiens	O00151	Anti Tag CoIP	33961781
种属内	IFNAR2	P48551	CREBBP	Homo sapiens	Q92793	Anti Tag CoIP	17923090
种属内	IFNAR2	P48551	CREBBP	Homo sapiens	Q92793	Anti Bait CoIP	17923090

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 IFNAR2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72613	IFN-alpha/beta R2 Protein, Human (HEK293, His)	P48551-1 (I27-K243)	≥95%
HY-P74860	IFN-alpha/beta R2 Protein, Human (HEK293, hFc)	P48551-1 (I27-K243)	≥95%
HY-P74861	IFN-alpha/beta R2 Protein, Human (Biotinylated, HEK293, His)	P48551-1 (I27-K243)	≥95%
HY-P74862A	IFN-alpha/beta R2 Protein, Human (HEK293, His, solution)	P48551-1 (I27-K243)	≥95%

关联疾病

疾病名称

别名

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Hepatitis C

Chronic Hepatitis C	Hepatitis C Infection
Hepatitis Nona Nonb	Nanbh
Viral Hepatitis C	Hepatitis C Chronic
Hepatitis C, Chronic	Chronic Type C Viral Hepatitis
Chronic Hcv - [Hepatitis C Virus] Infection	Hepatitis C Nos
Hepatitis C Infection Nos	Hepatitis C-Related Cirrhosis
Type C Viral Hepatitis	Hep C Nos

Multisystem Inflammatory Syndrome In Children

Mis-C	Multisystem Inflammatory Disorder In Children And Adolescents
Paediatric Inflammatory Multisystemic Syndrome	Mic

Immunodeficiency 28

IMD28	Ifngr2 Deficiency
Immunodeficiency 28, Mycobacteriosis, Autosomal Recessive	Immunodeficiency 28, Mycobacteriosis
Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Ifngammar2 Deficiency	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Interferon Gamma Receptor 2 Deficiency
Msmd Due To Complete Ifngammar2 Deficiency	Msmd Due To Complete Interferon Gamma Receptor 2 Deficiency
Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar2 Deficiency	Autosomal Recessive Msmd Due To Partial Ifngammar2 Deficiency
Autosomal Recessive Msmd Due To Partial Interferon Gamma Receptor 2 Deficiency	Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 2 Deficiency
Immunodeficiency, Type 28, Mycobacteriosis

Torch Syndrome

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Immunodeficiency 45

IMD45

Rubella

German Measles	Three Day Measles
Rubella Nos

Immunodeficiency 44

IMD44

Viral Infectious Disease

Arbovirus Infections	Viral Disease
Virus Infection	Virus Diseases
Viral Infection	Viral Infections
Virus Infections

Herpangina

Vesicular Pharyngitis

Immunodeficiency 39

IMD39

Immunodeficiency, Type 39

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Encephalopathy With Basal Ganglia Calcification	Aicardi-Goutières Syndrome
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Mumps

Parotitis Due To Mumps Virus	Mumps Nos
Epidemic Parotitis	Infectious Parotitis

West Nile Encephalitis

West-Nile Encephalitis	West Nile Fever
West Nile Fever Encephalitis	West Nile Fever With Encephalitis
West-Nile Fever	Encephalitis, West Nile Fever

Hepatitis B

Chronic Hepatitis B	Hepatitis B Infection
Serum Hepatitis	HBV
Hepatitis B Chronic	Hbv, Susceptibility To
Hepatitis B, Chronic	Chronic Hepatitis B Without Delta Agent
Chronic Hbv - [Hepatitis B Virus] Infection	Hepatitis B Nos
Chronic Type B Viral Hepatitis	Hep B Nos

Primary Immunodeficiency With Post-Measles-Mumps-Rubella Vaccine Viral Infection

Primary Immunodeficiency With Post-Mmr Vaccine Viral Infection

Measles

Rubeola	Morbilli
Measles Nos	Koplik Spots

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-W063968	RO8191		≥99.0%	否
HY-RS06583	Ifnar2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06582	IFNAR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06584	Ifnar2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	IFNAR2	VGNC	VGNC:30055
Rattus norvegicus	IFNAR2	RGD	RGD:1583177
Macaca mulatta	IFNAR2	VGNC	VGNC:81330
Felis catus	IFNAR2	VGNC	VGNC:103734
Mus musculus	IFNAR2	MGD	MGI:1098243
Macaca fascicularis	IFNAR2	NCBI	NCBI:102140083
Others	IFNAR2	NCBI

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营业执照（三证合一）

IFNAR2 - interferon alpha and beta receptor subunit 2 Gene

关于 IFNAR2

功能概要

IFNAR2 基因产物(8)

IFNAR2 蛋白结构

IFNAR2 蛋白互作信息

重组 IFNAR2 蛋白

关联疾病

直系同源

热门区域

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IFNAR2 - interferon alpha and beta receptor subunit 2 Gene

关于 IFNAR2

功能概要

IFNAR2 基因产物(8)

IFNAR2 蛋白结构

IFNAR2 蛋白互作信息

重组 IFNAR2 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z