JCHAIN - joining chain of multimeric IgA and IgM Gene

中文名称：连接多聚体 IgA 和 IgM 链

种属: Homo sapiens

同用名: IGJ; JCH; IGCJ

基因 ID: 3512 | 基因类型: protein coding

关于 JCHAIN

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,655,541-70,666,508 (from NCBI)

This gene has 5 transcripts (splice variants) and 126 orthologues. Biased expression in colon (RPKM 2264.9), duodenum (RPKM 2014.1) and 10 other tissues.

功能概要

启用 IgA 结合活性和蛋白质同源二聚化活性。有助于多种功能，包括免疫球蛋白受体结合活性；肽聚糖结合活性；和磷脂酰胆碱结合活性。参与多个过程，包括对其他生物体的防御反应；肾小球滤过；和呼吸爆发的正调节。位于细胞外空间。单体 IgA 免疫球蛋白复合物的一部分；五聚体 IgM 免疫球蛋白复合物；和分泌型二聚体 IgA 免疫球蛋白复合物。 [由基因组资源联盟提供，2022 年 4 月]

Enables IgA binding activity and protein homodimerization activity. Contributes to several functions, including immunoglobulin receptor binding activity; peptidoglycan binding activity; and phosphatidylcholine binding activity. Involved in several processes, including defense response to Other organism; glomerular filtration; and positive regulation of respiratory burst. Located in extracellular space. Part of monomeric IgA immunoglobulin complex; pentameric IgM immunoglobulin complex; and secretory dimeric IgA immunoglobulin complex. [provided by Alliance of Genome Resources, Apr 2022]

JCHAIN 基因产物(1)

mRNA	Protein	Name
NM_144646.4	NP_653247.1	immunoglobulin J chain precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables IgA binding	IMP IMP: 通过突变表型推断	17237408	GOA
contributes to immunoglobulin receptor binding	IDA IDA: 通过直接分析推断	23250751	GOA
contributes to immunoglobulin receptor binding	IMP IMP: 通过突变表型推断	17237408	GOA
contributes to peptidoglycan binding	IDA IDA: 通过直接分析推断	21786026	GOA
contributes to phosphatidylcholine binding	IDA IDA: 通过直接分析推断	21786026	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	21786026	GOA
contributes to single-stranded DNA binding	IDA IDA: 通过直接分析推断	21786026	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in adaptive immune response	IDA IDA: 通过直接分析推断	21786026	GOA
involved in antibacterial humoral response	IDA IDA: 通过直接分析推断	23250751	GOA
involved in glomerular filtration	IMP IMP: 通过突变表型推断	23398317	GOA
involved in innate immune response	IDA IDA: 通过直接分析推断	21786026	GOA
involved in positive regulation of respiratory burst	IDA IDA: 通过直接分析推断	24145934	GOA
involved in protein-containing complex assembly	IMP IMP: 通过突变表型推断	17237408	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of dimeric IgA immunoglobulin complex	IMP IMP: 通过突变表型推断	17237408	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	23398317	GOA
NOT part of hexameric IgM immunoglobulin complex	IDA IDA: 通过直接分析推断	21786026	GOA
part of monomeric IgA immunoglobulin complex	IDA IDA: 通过直接分析推断	23250751	GOA
part of pentameric IgM immunoglobulin complex	IDA IDA: 通过直接分析推断	21786026	GOA
part of secretory IgA immunoglobulin complex	IDA IDA: 通过直接分析推断	23250751	GOA
part of secretory dimeric IgA immunoglobulin complex	IDA IDA: 通过直接分析推断	24145934	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

JCHAIN 蛋白结构

Ig_J_chain

0
100
159 a.a.

蛋白主名

其他名称

immunoglobulin J chain

IgJ chain

重组 JCHAIN 蛋白

目录号	产品名	蛋白编号	纯度
HY-P74842	IgJ Protein, Human (His)	P01591/NP_653247.1 (Q23-D159)	≥95%

关联疾病

疾病名称

别名

Alpha Chain Disease

Seligmann'S Disease

Immunoproliferative Small Intestinal Disease

Mu Chain Disease

Mu-Chain Disease

Epiphyseal Chondrodysplasia, Miura Type

ECDM	Tall Stature-Scoliosis-Macrodactyly Of The Great Toes Syndrome
Miura Type Epiphyseal Chondrodysplasia	Tall Stature-Scoliosis-Macrodactyly Of The Halluces Syndrome
Tall Stature-Long Halluces-Multiple Extra-Epiphyses Syndrome	Chondrodysplasia, Epiphyseal, Miura Type

Immunoglobulin Alpha Deficiency

Iga Deficiency	Gamma-A-Globulin Deficiency
Immunoglobulin A Deficiency

Hodgkin'S Lymphoma, Lymphocytic-Histiocytic Predominance

Hodgkin Disease	Hodgkin Lymphoma, Lymphocyte-Rich
Hodgkin Lymphoma, Lymphocytic-Histiocytic Predominance	Hodgkin'S Disease, Lymphocyte Predominance
Lymphocyte Rich Hodgkin'S Disease	Lymphocyte Rich Classical Hodgkin Lymphoma

Heavy Chain Disease

Hcd

Ciliary Dyskinesia, Primary, 7

Primary Ciliary Dyskinesia 7	CILD7
Ciliary Dyskinesia, Primary, 7, With Or Without Situs Inversus	Primary Ciliary Dyskinesia 7 With Or Without Situs Inversus
Ics7	Immotile Cilia Syndrome 7
Dyskinesia, Ciliary, Primary, 7

Isolated Growth Hormone Deficiency

Congenital Ighd	Congenital Isolated Gh Deficiency
Congenital Isolated Growth Hormone Deficiency	Non-Acquired Isolated Growth Hormone Deficiency
Pituitary Dwarfism	Dwarfism, Pituitary
Isolated Somatotropin Deficiency	Isolated Congenital Growth Hormone Deficiency
Familial Isolated Growth Hormone Deficiency	Ighd
Dwarfism, Growth Hormone Deficiency	Growth Hormone Deficiency Dwarfism
Isolated Gh Deficiency	Isolated Hgh Deficiency
Isolated Human Growth Hormone Deficiency	Isolated Somatotropin Deficiency Disorder
Dwarfism Pituitary

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P3479	Insulin (swine)		98.36%	否
HY-P4890A	Relaxin H3 (human) (TFA)		/	否
HY-P10204	FZD7 antagonist 1		/	否
HY-P10693	CZEN-002	Inhibitor	/	否
HY-P1372	PKC ζ pseudosubstrate	Inhibitor	/	否
HY-P4062	Insulin peglispro		/	否
HY-P4890	Relaxin H3 (human)		/	否
HY-RS07033	JCHAIN Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	JCHAIN	VGNC	VGNC:106622
Canis familiaris	JCHAIN	VGNC	VGNC:42184
Rattus norvegicus	JCHAIN	RGD	RGD:1310155
Felis catus	JCHAIN	VGNC	VGNC:107339
Bos taurus	JCHAIN	VGNC	VGNC:30373
Mus musculus	JCHAIN	MGD	MGI:96493
Others	JCHAIN	NCBI

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