1. Gene
  2. SLCO4C1 - solute carrier organic anion transporter family member 4C1 Gene

SLCO4C1 - solute carrier organic anion transporter family member 4C1 Gene

中文名称:溶质载体有机阴离子转运家族成员 4C1

种属: Homo sapiens

同用名: OATPX; OATP-H; OATP-M1; OATP4C1; PRO2176; SLC21A20

基因 ID: 353189 | 基因类型: protein coding

关于 SLCO4C1

Cytogenetic location: 5q21.1 Genomic coordinates (GRCh38): 5:102,233,986-102,296,284 (from NCBI)

This gene has 1 transcript (splice variant), 136 orthologues and 10 paralogues. Biased expression in kidney (RPKM 21.4), lung (RPKM 4.2) and 4 other tissues.

功能概要

SLCO4C1 属于有机阴离子转运蛋白 (OATP) 家族。 OATP 参与胆汁酸、结合类固醇、甲状腺激素、类花生酸、肽和许多组织中许多药物的膜转运 (Mikkaichi 等人,2004 [PubMed 14993604]) 。[OMIM 提供,2008 年 3 月]

SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated Steroids, thyroid hormone, eicosanoids, Peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).[supplied by OMIM, Mar 2008]

SLCO4C1 基因产物(1)

mRNA Protein Name
NM_180991.5 NP_851322.3 solute carrier organic anion transporter family member 4C1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables organic anion transmembrane transporter activity IDA
IDA: 通过直接分析推断
19129463 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SLCO4C1 蛋白结构

OATP

OATP: Organic Anion Transporter Polypeptide (OATP) family (107 - 664)

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (507 - 547)

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  • 724 a.a.
蛋白主名 其他名称

solute carrier organic anion transporter family member 4C1

organic anion transporter M1

直系同源

种属 基因名 来源 基因 ID
Bos taurus SLCO4C1 VGNC VGNC:34955
Mus musculus SLCO4C1 MGD MGI:2442784
Macaca mulatta SLCO4C1 VGNC VGNC:77764
Rattus norvegicus SLCO4C1 RGD RGD:1303048
Canis familiaris SLCO4C1 VGNC VGNC:46499
Felis catus SLCO4C1 VGNC VGNC:65448