2. Gene
  3. LILRA5 - leukocyte immunoglobulin like receptor A5 Gene

LILRA5 - leukocyte immunoglobulin like receptor A5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：白细胞免疫球蛋白样受体 A5

种属: Homo sapiens

同用名: CD85; LIR9; CD85F; ILT11; LIR-9; ILT-11; LILRB7

基因 ID: 353514 | 基因类型: protein coding

关于 LILRA5

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,307,070-54,313,166 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 295 orthologues and 25 paralogues. Biased expression in appendix (RPKM 29.5), bone marrow (RPKM 22.9) and 4 other tissues.

功能概要

该基因编码的蛋白质是白细胞免疫球蛋白样受体 (LIR) 家族的成员。已知 LIR 家族成员在白细胞中具有激活和抑制功能。这种受体蛋白在单核细胞表面的交联已被证明可诱导钙流和多种促炎细胞因子的分泌，这表明该蛋白在触发先天免疫反应中的作用。该基因是在染色体区域 19q13.4 上形成基因簇的白细胞受体基因之一。已经描述了编码不同亚型的四种可变剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

LILRA5 基因产物(4)

mRNA Protein Name
NM_021250.4 NP_067073.1 leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 1 precursor
NM_181879.3 NP_870994.1 leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 3
NM_181985.4 NP_871714.1 leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 2
NM_181986.3 NP_871715.1 leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 4
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of interleukin-12 production IDA
IDA: 通过直接分析推断
19009525 GOA
involved in negative regulation of interleukin-13 production IDA
IDA: 通过直接分析推断
19009525 GOA
involved in positive regulation of MAPK cascade IMP
IMP: 通过突变表型推断
19009525 GOA
involved in positive regulation of calcium ion transport IDA
IDA: 通过直接分析推断
12393390 GOA
involved in positive regulation of cell activation IDA
IDA: 通过直接分析推断
12393390 GOA
involved in positive regulation of inflammatory response IDA
IDA: 通过直接分析推断
12393390 GOA
involved in positive regulation of interleukin-1 beta production IDA
IDA: 通过直接分析推断
12393390 GOA
involved in positive regulation of interleukin-10 production IDA
IDA: 通过直接分析推断
19009525 GOA
involved in positive regulation of interleukin-6 production IDA
IDA: 通过直接分析推断
12393390 GOA
involved in positive regulation of protein tyrosine kinase activity IMP
IMP: 通过突变表型推断
19009525 GOA
involved in positive regulation of tumor necrosis factor production IDA
IDA: 通过直接分析推断
12393390 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
19009525 GOA
located in extracellular space IMP
IMP: 通过突变表型推断
12393390 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LILRA5 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (48 - 135)

Ig_3

Ig_3: Immunoglobulin domain (141 - 217)

  • 0
  • 100
  • 200
  • 265 a.a.
蛋白主名 其他名称

leukocyte immunoglobulin-like receptor subfamily A member 5

CD85 antigen-like family member F

重组 LILRA5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72394 LILRA5/CD85f Protein, Human (Biotinylated, HEK293, His-Avi) A6NI73-1 (G42-R268) ≥95%
HY-P72521 LILRA5/CD85f Protein, Human (HEK293, His) A6NI73-1 (G42-R268) ≥95%
HY-P75909 LILRA5/CD85f Protein, Human (Biotinylated, HEK293, His) A6NI73-1 (G42-R268) ≥95%
HY-P75910 LILRA5/CD85f Protein, Human (HEK293, Fc) A6NI73-1 (G42-R268) ≥95%
HY-P78481 LILRA5/CD85f Protein, Human (HEK293, His-Avi) A6NI73-1 (G42-R268) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07649 LILRA5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LILRA5 RGD RGD:1582781
Mus musculus LILRA5 MGD MGI:3647196
Macaca mulatta LILRA5 VGNC VGNC:82174
Others LILRA5 NCBI
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