IL9R - interleukin 9 receptor Gene

中文名称：白细胞介素 9 受体

种属: Homo sapiens

同用名: CD129; IL-9R

基因 ID: 3581 | 基因类型: protein coding

关于 IL9R

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:155,997,696-156,013,020 (from NCBI)

This gene has 4 transcripts (splice variants), 172 orthologues and 7 paralogues. Biased expression in urinary bladder (RPKM 2.4), lymph node (RPKM 1.3) and 11 other tissues.

功能概要

该基因编码的蛋白质是一种细胞因子受体，可特异性介导白细胞介素 9 (IL9) 的生物学效应。功能性 IL9 受体复合物需要这种蛋白质以及白细胞介素 2 受体，γ (IL2RG) ，一种由许多不同细胞因子的受体共享的常见γ亚基。该受体的配体结合导致各种 JAK 激酶和 STAT 蛋白的激活，它们与不同的生物反应相关。该基因位于 X 和 Y 染色体的假常染色体区域。遗传学研究表明该基因与哮喘的发展有关。已经描述了 9、10、16 和 18 号染色体上的多个假基因。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

IL9R 基因产物(2)

mRNA	Protein	Name
NM_002186.3	NP_002177.2	interleukin-9 receptor isoform 1 precursor
NM_176786.2	NP_789743.2	interleukin-9 receptor isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables interleukin-9 receptor activity	IDA IDA: 通过直接分析推断	8193355	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in interleukin-9-mediated signaling pathway	IDA IDA: 通过直接分析推断	8756628	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in plasma membrane	IDA IDA: 通过直接分析推断	18829468	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

interleukin-9 receptor

IL-9 receptor

关联疾病

疾病名称

别名

Deafness, Y-Linked 2

DFNY2

Y-Linked Deafness 2

Bronchitis

Chronic Bronchitis	Acute Bronchitis
Bronchitis, Chronic	Acute Bronchitis And Bronchiolitis
Chest Cold	Chest Infection
Ci - Chest Infection	Recurrent Wheezy Bronchitis
Bronchitis Chronic	Lower Respiratory Tract Infection
Acute Lower Respiratory Tract Infection	Chronic Bronchitis Nos
Senile Bronchitis	Bronchitis Nos In Those Under L5 Years Of Age
Bronchitis Nos

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Mcd Diffuse Large B-Cell Lymphoma

Mcd Dlbcl

Doid:0081066

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06782	IL9R Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	IL9R	MGD	MGI:96564
Rattus norvegicus	IL9R	RGD	RGD:2907
Bos taurus	IL9R	VGNC	VGNC:30172
Macaca mulatta	IL9R	VGNC	VGNC:81422
Felis catus	IL9R	VGNC	VGNC:67788
Others	IL9R	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

IL9R - interleukin 9 receptor Gene

关于 IL9R

功能概要

IL9R 基因产物(2)

关联疾病

直系同源

热门区域

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IL9R - interleukin 9 receptor Gene

关于 IL9R

功能概要

IL9R 基因产物(2)

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z