Top2a - DNA topoisomerase II alpha Gene

中文名称：DNA 拓扑异构酶 II α

种属: Rattus norvegicus

关于 Top2a

功能概要

该基因编码的蛋白可启动多项功能，包括 ATP 绑定活动； DNA 拓扑异构酶 II 型（双链切割，ATP 水解）活性；和染色质结合活性。涉及多个过程，包括 DNA 拓扑变化；小脑皮层形成；和对甲状旁腺激素的反应。位于核仁。 DNA 拓扑异构酶 II 型（双链切割，ATP 水解）复合物的一部分。与人类 TOP2A（DNA 拓扑异构酶 II α）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; DNA Topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; and chromatin binding activity. Involved in several processes, including DNA topological change; cerebellar cortex formation; and response to parathyroid hormone. Located in nucleolus. Part of DNA Topoisomerase type II (double strand cut, ATP-hydrolyzing) complex. Orthologous to human TOP2A (DNA Topoisomerase II alpha). [provided by Alliance of Genome Resources, Apr 2022]