2. Gene
  3. Sirt2 - sirtuin 2 Gene

Sirt2 - sirtuin 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：沉默信息调节因子 2 相关酶类 2

种属: Rattus norvegicus

基因 ID: 361532 | 基因类型: protein coding

关于 Sirt2

Primary_assembly 1: 84,052,903-84,076,975 forward strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 187 orthologues, 6 paralogues and is associated with 3 phenotypes. Biased expression in Brain (RPKM 274.8), Muscle (RPKM 27.6) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 NAD 依赖性蛋白质脱乙酰酶活性和微管蛋白脱乙酰酶活性。参与多个过程，包括神经系统发育；调节神经系统发育；和突触后神经递质受体内化的调节。位于多个细胞成分中，包括 Schmidt-Lanterman 切迹；侧环;和主轴突。在谷氨酸能突触中活跃。用于研究高级别胶质瘤和非酒精性脂肪肝。间歇性跛行的生物标志物。与人类 SIRT2（sirtuin 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables NAD-dependent protein deacetylase activity and tubulin deacetylase activity. Involved in several processes, including nervous system development; regulation of nervous system development; and regulation of postsynaptic neurotransmitter receptor internalization. Located in several cellular components, including Schmidt-Lanterman incisure; lateral loop; and main axon. Is active in glutamatergic synapse. Used to study high grade glioma and non-alcoholic fatty liver disease. Biomarker of intermittent claudication. Orthologous to human SIRT2 (Sirtuin 2). [provided by Alliance of Genome Resources, Apr 2022]

Sirt2 基因产物(2)

mRNA Protein Name
NM_001399631.1 NP_001386560.1 NAD-dependent protein deacetylase sirtuin-2 isoform 2
NM_001399630.1 NP_001386559.1 NAD-dependent protein deacetylase sirtuin-2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NAD-dependent protein lysine deacetylase activity IDA
IDA: 通过直接分析推断
17344398 RGD
enables tubulin deacetylase activity IDA
IDA: 通过直接分析推断
17344398 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in myelination in peripheral nervous system IMP
IMP: 通过突变表型推断
21949390 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
23522375 RGD
involved in negative regulation of oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
17344398 RGD
involved in negative regulation of oligodendrocyte progenitor proliferation IMP
IMP: 通过突变表型推断
17344398 RGD
involved in protein deacetylation IMP
IMP: 通过突变表型推断
21949390 RGD
involved in regulation of myelination IMP
IMP: 通过突变表型推断
21949390 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization EXP
EXP: 通过实验结果推断
28793258 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: 通过直接分析推断
28793258 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IEP
IEP: 通过表达模式推断
28793258 RGD
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: 通过突变表型推断
28793258 RGD
involved in response to cocaine IEP
IEP: 通过表达模式推断
27664298 RGD
involved in tubulin deacetylation IDA
IDA: 通过直接分析推断
17344398 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Schmidt-Lanterman incisure IDA
IDA: 通过直接分析推断
21949390 RGD
located in glial cell projection IDA
IDA: 通过直接分析推断
17344398 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
28793258 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
28793258 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
28793258 RGD
located in heterochromatin IDA
IDA: 通过直接分析推断
17344398 RGD
located in juxtaparanode region of axon IDA
IDA: 通过直接分析推断
17344398 RGD
located in lateral loop IDA
IDA: 通过直接分析推断
21949390 RGD
located in myelin sheath IDA
IDA: 通过直接分析推断
17344398 RGD
located in myelin sheath abaxonal region IDA
IDA: 通过直接分析推断
17344398 RGD
located in paranodal junction IDA
IDA: 通过直接分析推断
17344398 RGD
located in paranode region of axon IDA
IDA: 通过直接分析推断
17344398 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
17344398 RGD
located in terminal loop IDA
IDA: 通过直接分析推断
17344398 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Sirt2 蛋白结构

SIRT1

SIRT1: cd01408 (105 - 431)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 489 a.a.
蛋白主名 其他名称

NAD-dependent protein deacetylase sirtuin-2

5E5 antigen

NAD-dependent deacetylase sirtuin-2

NAD-dependent protein defatty-acylase sirtuin-2

SIR2-like protein 2

regulatory protein SIR2 homolog 2

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0150 Nicotinamide Inhibitor 99.99% 是
HY-B0879A Suramin sodium salt Inhibitor 99.48% 是
HY-B0879 Suramin Inhibitor / 否
HY-B0150A Nicotinamide Hydrochloride Inhibitor / 否
Pre-clinical Phase
生物活性分子 (43)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10532 SRT 1720 Activator 99.90% 否
HY-107454 OSS_128167 Inhibitor 98.63% 否
HY-100578 AGK2 Inhibitor 99.62% 否
HY-15145 SRT 1720 monohydrochloride Activator 99.92% 否
HY-13515 Sirtinol Inhibitor ≥98.0% 否
HY-101278 Thiomyristoyl Inhibitor 99.74% 否
HY-100591 SirReal2 Inhibitor ≥99.0% 否
HY-16691 AK-7 Inhibitor 99.93% 否
HY-100732 Cambinol Inhibitor 99.89% 否
HY-15510 Tenovin-6 Inhibitor 98.33% 否
HY-101073 Salermide Inhibitor ≥98.0% 否
HY-136199 SIRT1-IN-1 Inhibitor 98.19% 否
HY-103636 PROTAC Sirt2 Degrader-1 Inhibitor 98.71% 否
HY-101465 AK-1 Inhibitor 99.97% 否
HY-16616 SIRT-IN-2 Inhibitor 98.08% 否
HY-N1926 Dihydrocoumarin Inhibitor 99.81% 否
HY-146689 SIRT1-IN-2 Inhibitor 98.86% 否
HY-15510B Tenovin-6 Hydrochloride Inhibitor 98.88% 否
HY-107660 SIRT2-IN-8 Inhibitor 99.32% 否
HY-B0150R Nicotinamide (Standard) Inhibitor 99.85% 否
HY-112427 Sirt2-IN-1 Inhibitor 98.71% 否
HY-151519 SIRT2-IN-9 Inhibitor 99.45% 否
HY-16615 SIRT-IN-1 Inhibitor 98.58% 否
HY-146690 SIRT1-IN-3 Inhibitor 99.18% 否
HY-148408 SIRT2-IN-11 Inhibitor 99.94% 否
HY-147233 MIND4-19 Inhibitor 99.94% 否
HY-111522 RK-9123016 Inhibitor 99.02% 否
HY-111329 JGB1741 Inhibitor 99.05% 否
HY-111303 CHIC35 Inhibitor / 否
HY-160617 SIRT2-IN-14 Inhibitor / 否
HY-145958 Sirt2-IN-6 Inhibitor / 否
HY-118343 AC-93253 Inhibitor / 否
HY-163532 FLS-359 Modulator / 否
HY-149637 HSP70/SIRT2-IN-1 Inhibitor / 否
HY-160944 hsa62 Inhibitor / 否
HY-123653 SirReal-1 Inhibitor / 否
HY-150727 SIRT5 inhibitor 4 Inhibitor / 否
HY-115979 Sirt2-IN-5 Inhibitor / 否
HY-146013 Sirt1/2-IN-1 Inhibitor / 否
HY-W841840 SR94 Inhibitor / 否
HY-156027 SIRT6-IN-3 Inhibitor / 否
HY-119889 A1B11 Inhibitor / 否
HY-117442 A2B57 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sirt2 NCBI NCBI:22933
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