2. Gene
  3. INHBA - inhibin subunit beta A Gene

INHBA - inhibin subunit beta A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：抑制素β亚基 A

种属: Homo sapiens

同用名: EDF; FRP

基因 ID: 3624 | 基因类型: protein coding

关于 INHBA

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:41,685,114-41,705,406 (from NCBI)

This gene has 5 transcripts (splice variants), 281 orthologues, 31 paralogues and is associated with 1 phenotype. Broad expression in endometrium (RPKM 12.3), gall bladder (RPKM 11.3) and 15 other tissues.

功能概要

该基因编码 TGF-β (转化生长因子-β) 蛋白质超家族的成员。编码的前原蛋白经过蛋白水解处理，生成二聚体激活素和抑制素蛋白复合物的一个亚基。这些复合物分别激活和抑制垂体分泌促卵泡激素。编码的蛋白质还在眼睛、牙齿和睾丸发育中发挥作用。该基因表达升高可能与人类患者的癌症恶病质有关。[RefSeq 提供，2016 年 8 月]

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with Cancer cachexia in human patients. [provided by RefSeq, Aug 2016]

INHBA 基因产物(1)

mRNA Protein Name
NM_002192.4 NP_002183.1 inhibin beta A chain preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cytokine activity IDA
IDA: 通过直接分析推断
9884026 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
2575216 GOA
enables peptide hormone binding IPI
IPI: 通过物理相互作用推断
16198295 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
2575216 GOA
enables type II activin receptor binding IPI
IPI: 通过物理相互作用推断
7890768 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in GABAergic neuron differentiation IDA
IDA: 通过直接分析推断
25804741 GOA
involved in activin receptor signaling pathway IDA
IDA: 通过直接分析推断
9884026 GOA
involved in endodermal cell differentiation IDA
IDA: 通过直接分析推断
21828274 GOA
involved in extrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
9884026 GOA
involved in hair follicle development IGI
IGI: 通过遗传相互作用推断
10932194 GOA
involved in hematopoietic progenitor cell differentiation IDA
IDA: 通过直接分析推断
15451575 GOA
involved in hemoglobin biosynthetic process IDA
IDA: 通过直接分析推断
1310063 GOA
involved in male gonad development IGI
IGI: 通过遗传相互作用推断
10932194 GOA
involved in negative regulation of G1/S transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
9884026 GOA
involved in negative regulation of cell growth IDA
IDA: 通过直接分析推断
9884026 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
11948405 GOA
involved in odontogenesis IGI
IGI: 通过遗传相互作用推断
10932194 GOA
involved in ovarian follicle development IGI
IGI: 通过遗传相互作用推断
10932194 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
21281489 GOA
involved in positive regulation of SMAD protein signal transduction IDA
IDA: 通过直接分析推断
19736306 GOA
involved in positive regulation of erythrocyte differentiation IDA
IDA: 通过直接分析推断
9032295 GOA
involved in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: 通过直接分析推断
8267637 GOA
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
23812417 GOA
involved in positive regulation of protein metabolic process IDA
IDA: 通过直接分析推断
21828274 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12702211 GOA
involved in progesterone secretion IGI
IGI: 通过遗传相互作用推断
10932194 GOA
involved in regulation of follicle-stimulating hormone secretion IGI
IGI: 通过遗传相互作用推断
10932194 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11948405 GOA
involved in roof of mouth development IGI
IGI: 通过遗传相互作用推断
10932194 GOA
involved in striatal medium spiny neuron differentiation IDA
IDA: 通过直接分析推断
25804741 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of activin A complex IDA
IDA: 通过直接分析推断
7890768 GOA
part of enzyme activator complex IDA
IDA: 通过直接分析推断
12660162 GOA
located in extracellular region IDA
IDA: 通过直接分析推断
12213882 GOA
part of inhibin A complex IDA
IDA: 通过直接分析推断
7890768 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

INHBA 蛋白结构

TGFb_propeptide

TGFb_propeptide: TGF-beta propeptide (48 - 295)

TGF_beta

TGF_beta: Transforming growth factor beta like domain (319 - 426)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 426 a.a.
蛋白主名 其他名称

inhibin beta A chain

FSH-releasing protein

重组 INHBA 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70311 Activin A Protein, Human/Mouse/Rat (HEK293) P08476 (G311-S426) ≥95%
HY-P700159AF Animal-Free Activin A Protein, Human/Mouse/Rat (His) P08476 (G311-S426) ≥95%

关联疾病

疾病名称 别名
Ovary Adenocarcinoma

Ovarian Adenocarcinoma

Adenocarcinoma Of The Ovary

Ovarian Adenoacanthoma

Adenocarcinoma Of Ovary
Sex Cord-Gonadal Stromal Tumor

Sex Cord-Gonadal Stromal Tumour

Sex Cord Stromal Tumour

Sex Cord-Stromal Neoplasm

Specialized Gonadal Neoplasm

Specialized Gonadal Tumor

Specialized Gonadal Tumour

Sex Cord-Gonadal Stromal Tumors

Sex Cord-Stromal Tumor

Malignant Testicular Sex Cord-Stromal Tumor

Sex Cord Stromal Tumor Of Testis
Clear Cell Adenocarcinoma

Mesonephroma

Water-Clear Cell Adenocarcinoma

Adenocarcinoma, Clear Cell

Malignant Mesonephroma

Mesonephroid Clear Cell Carcinoma

Mesonephroma, Malignant

Water-Clear Cell Carcinoma

Wolffian Duct Neoplasm

Adenocarcinoma Clear Cell

Mesonephric Tumor
Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06813 INHBA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus INHBA MGD MGI:96570
Macaca mulatta INHBA VGNC VGNC:81334
Canis familiaris INHBA VGNC VGNC:42021
Bos taurus INHBA VGNC VGNC:30200
Felis catus INHBA VGNC VGNC:80600
Rattus norvegicus INHBA RGD RGD:62074
Others INHBA NCBI
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