2. Gene
  3. INHBB - inhibin subunit beta B Gene

INHBB - inhibin subunit beta B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：抑制素β亚基 B

种属: Homo sapiens

基因 ID: 3625 | 基因类型: protein coding

关于 INHBB

Cytogenetic location: 2q14.2 Genomic coordinates (GRCh38): 2:120,346,136-120,351,803 (from NCBI)

This gene has 1 transcript (splice variant), 266 orthologues and 31 paralogues. Biased expression in fat (RPKM 16.6), testis (RPKM 13.1) and 13 other tissues.

功能概要

该基因编码 TGF-β (转化生长因子-β) 蛋白质超家族的成员。编码的前原蛋白经过蛋白水解处理，生成二聚体激活素和抑制素蛋白复合物的一个亚基。这些复合物分别激活和抑制垂体分泌促卵泡激素。该基因附近的多态性与女性人类患者的先兆子痫有关。[RefSeq 提供，2016 年 8 月]

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Polymorphisms near this gene are associated with pre-eclampsia in female human patients. [provided by RefSeq, Aug 2016]

INHBB 基因产物(1)

mRNA Protein Name
NM_002193.4 NP_002184.2 inhibin beta B chain preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
2575216 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
2575216 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activin receptor signaling pathway IDA
IDA: 通过直接分析推断
16650820 GOA
involved in negative regulation of follicle-stimulating hormone secretion IPI
IPI: 通过物理相互作用推断
3122219 GOA
involved in negative regulation of hepatocyte growth factor production IDA
IDA: 通过直接分析推断
12419948 GOA
involved in positive regulation of follicle-stimulating hormone secretion IPI
IPI: 通过物理相互作用推断
3122219 GOA
involved in response to wounding IEP
IEP: 通过表达模式推断
10320815 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
16650820 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

INHBB 蛋白结构

TGFb_propeptide

TGFb_propeptide: TGF-beta propeptide (66 - 278)

TGF_beta

TGF_beta: Transforming growth factor beta like domain (301 - 406)

  • 0
  • 100
  • 200
  • 300
  • 407 a.a.
蛋白主名 其他名称

inhibin beta B chain

Inhibin, beta-2

重组 INHBB 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73242 INHBB Protein, Human (HEK293, His) P09529/NP_002184.2 (S29-A407) ≥95%
HY-P700013AF Animal-Free INHBB Protein, Human (His) P09529 (G293-A407) ≥95%

INHBB 抗体

目录号 产品名 应用 反应物种
HY-P81932 Inhibin beta B Antibody (YA1677) WB Human, Mouse, Rat

关联疾病

疾病名称 别名
Eclampsia

Eclampsia In Puerperium

Postpartum Eclampsia

Eclampsia, Postpartum

Puerperal Eclampsia
Pre-Eclampsia

Preeclampsia

Gestational Hypertension

Hypertension Induced By Pregnancy

Pre-Eclamptic Toxaemia

Pregnancy Associated Hypertension

Proteinuric Hypertension Of Pregnancy

Hypertension, Pregnancy-Induced, Susceptibility To

Preeclampsia/Eclampsia

Pregnancy Toxemia

Toxaemia Of Pregnancy

Gestational Proteinuric Hypertension

Pregnancy-Induced Hypertension

Toxemia Of Pregnancy

Preeclampsia, Susceptibility To

Transient Hypertension Of Pregnancy

Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

Gestational Hypertension Nos

Mild Proteinuric Hypertension Of Pregnancy

Pih - [Pregnancy-Induced Hypertension]

Pregnancy-Induced Hypertension Nos

Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

Pe - [Pre-Eclampsia]

Pre-Eclampsia Nos

Pre-Eclamptic Nos

Pregnancy Pre-Eclampsia

Puerperal Pre-Eclampsia

Pre-Eclampsia Toxaemia

Toxaemia In Pregnancy

Pet - [Pre-Eclamptic Toxaemia]

Maternal Toxaemia
Dyskeratosis Congenita, Autosomal Recessive 2

DKCB2

Autosomal Recessive Dyskeratosis Congenita 2

Dyskeratosis Congenita, Autosomal Recessive, 2

Dyskeratosis Congenita, Autosomal Recessive, Type 2
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06814 INHBB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus INHBB MGD MGI:96571
Canis familiaris INHBB VGNC VGNC:42022
Bos taurus INHBB VGNC VGNC:30201
Rattus norvegicus INHBB RGD RGD:2913
Felis catus INHBB VGNC VGNC:107566
Macaca mulatta INHBB VGNC VGNC:104539
Others INHBB NCBI
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