2. Gene
  3. INPP1 - inositol polyphosphate-1-phosphatase Gene

INPP1 - inositol polyphosphate-1-phosphatase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肌醇多磷酸-1-磷酸酶

种属: Homo sapiens

基因 ID: 3628 | 基因类型: protein coding

关于 INPP1

Cytogenetic location: 2q32.2 Genomic coordinates (GRCh38): 2:190,343,589-190,371,665 (from NCBI)

This gene has 15 transcripts (splice variants), 209 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 21.9), esophagus (RPKM 18.0) and 24 other tissues.

功能概要

该基因编码肌醇多磷酸-1-磷酸酶，这是参与磷脂酰肌醇信号通路的酶之一。该酶从多磷酸肌醇 1,4-二磷酸和肌醇 1,3,4-三磷酸中去除肌醇环位置 1 的磷酸基团。[RefSeq 提供，2008 年 7 月]

This gene encodes the Enzyme inositol polyphosphate-1-phosphatase, one of the Enzymes involved in phosphatidylinositol signaling pathways. This Enzyme removes the phosphate group at position 1 of the inositol ring from the polyphosphates inositol 1,4-bisphosphate and inositol 1,3,4-trisphophosphate. [provided by RefSeq, Jul 2008]

INPP1 基因产物(2)

mRNA Protein Name
NM_001128928.2 NP_001122400.1 inositol polyphosphate 1-phosphatase
NM_002194.4 NP_002185.1 inositol polyphosphate 1-phosphatase
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
26871637 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

INPP1 蛋白结构

Inositol_P

Inositol_P: Inositol monophosphatase family (57 - 378)

  • 0
  • 100
  • 200
  • 300
  • 399 a.a.
蛋白主名 其他名称

inositol polyphosphate 1-phosphatase

IPP

INPP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
INPP1 P49441 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
26871637
种属内
INPP1 P49441 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
26871637
种属内
INPP1 P49441 MEOX2 Homo sapiens Q6FHY5
Y2H Array
26871637
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 INPP1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70361 INPP1 Protein, Human (HEK293, His) P49441 (M1-T399) ≥95%

关联疾病

疾病名称 别名
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Ring Dermoid Of Cornea

RDC

Ring Dermoid Syndrome

Bilateral, Annular Limbal Dermoids With Corneal And Conjunctival Extension

Dermoid Of Cornea, Ring
Cone-Rod Dystrophy 5

CORD5

Dystrophy, Cone-Rod, Type 5
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-151374 3-IN-PP1 Inhibitor 99.58% 否
HY-RS06824 INPP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris INPP1 VGNC VGNC:42027
Rattus norvegicus INPP1 RGD RGD:1306071
Bos taurus INPP1 VGNC VGNC:30208
Macaca mulatta INPP1 VGNC VGNC:73746
Felis catus INPP1 VGNC VGNC:107567
Mus musculus INPP1 MGD MGI:104848
Others INPP1 NCBI
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