AQP7 - aquaporin 7 Gene

中文名称：水通道蛋白 7

种属: Homo sapiens

同用名: AQP7L; AQPap; GLYCQTL

基因 ID: 364 | 基因类型: protein coding

关于 AQP7

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:33,383,191-33,402,568 (from NCBI)

This gene has 19 transcripts (splice variants), 202 orthologues, 11 paralogues and is associated with 1 phenotype. Biased expression in fat (RPKM 81.2), heart (RPKM 10.9) and 3 other tissues.

功能概要

该基因编码水选择性膜通道水通道蛋白家族的成员。编码的蛋白质定位于质膜并允许水、甘油和尿素移动穿过细胞膜。该基因在脂肪组织中高度表达，其中编码的蛋白质促进甘油的流出。在肾脏的近端直管中，编码的蛋白质定位于顶膜并阻止甘油排泄到尿液中。编码的蛋白质存在于精子细胞以及睾丸和附睾精子中，表明在晚期精子发生中具有重要作用。该基因的可变剪接导致编码不同亚型的多个转录变体。该基因位于 9 号染色体上的相关水通道蛋白基因附近。已鉴定出该基因的多个假基因。[RefSeq 提供，2015 年 12 月]

This gene encodes a member of the Aquaporin family of water-selective membrane channels. The encoded protein localizes to the plasma membrane and allows movement of water, glycerol and urea across cell membranes. This gene is highly expressed in the adipose tissue where the encoded protein facilitates efflux of glycerol. In the proximal straight tubules of kidney, the encoded protein is localized to the apical membrane and prevents excretion of glycerol into urine. The encoded protein is present in spermatids, as well as in the testicular and epididymal spermatozoa suggesting an important role in late spermatogenesis. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related Aquaporin gene on chromosome 9. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Dec 2015]

AQP7 基因产物(7)

mRNA	Protein	Name
NM_001170.3	NP_001161.1	aquaporin-7 isoform 1
NM_001318156.2	NP_001305085.1	aquaporin-7 isoform 2
NM_001318157.2	NP_001305086.1	aquaporin-7 isoform 3
NM_001318158.2	NP_001305087.1	aquaporin-7 isoform 4
NM_001376191.1	NP_001363120.1	aquaporin-7 isoform 1
NM_001376192.1	NP_001363121.1	aquaporin-7 isoform 5
NM_001376193.1	NP_001363122.1	aquaporin-7 isoform 5

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables glycerol channel activity	EXP EXP: 通过实验结果推断	9405233	GOA
enables glycerol channel activity	IDA IDA: 通过直接分析推断	11952783	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	27832861	GOA
enables water channel activity	IDA IDA: 通过直接分析推断	11952783	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in glycerol transmembrane transport	IDA IDA: 通过直接分析推断	11952783	GOA
involved in water transport	IDA IDA: 通过直接分析推断	11952783	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell-cell junction	IDA IDA: 通过直接分析推断	18718702	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	18718702	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	11952783	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AQP7 蛋白结构

MIP

0
100
200
300
342 a.a.

蛋白主名

其他名称

aquaporin-7

aquaglyceroporin-7

AQP7 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	AQP7	O14520	PLIN1	Homo sapiens	O60240	Pull Down	27832861

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Glycerol Quantitative Trait Locus

Glycerol Release During Exercise, Defective

GLYCQTL

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Hydrarthrosis

Spermatogenic Failure 8

SPGF8

Constipation

Nephrogenic Diabetes Insipidus

Vasopressin-Resistant Diabetes Insipidus	Diabetes Insipidus, Nephrogenic
Diabetes Insipidus Nephrogenic	Congenital Nephrogenic Diabetes Insipidus
Adh Resistant Diabetes Insipidus	Diabetes Insipidus Nephrogenic X-Linked
Diabetes Insipidus Nephrogenic Type 1	Adh-Resistant Diabetes Insipidus
Diabetes Insipidus Renalis	Ndi
Renal Diabetes Insipidus	Familial Nephrogenic Diabetes
Antidiuretic-Hormone-Resistant Diabetes Insipidus	Adiuretin-Resistant Diabetes Insipidus
Ndi - [Nephrogenic Diabetes Insipidus]	Diabetes Tenuifluus
Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus	Hereditary Nephrogenic Diabetes Insipidus
Familial Nephrogenic Diabetes Insipidus	Primary Nephrogenic Diabetes Insipidus

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Psoriasis 11

PSORS11	Psoriasis Susceptibility 11
Psoriasis	Psoriasis Vulgaris
Psoriasis 11, Susceptibility To	Pv

Oligohydramnios

Oligohydramnios - Delivered	Antepartum Oligohydramnios
Delivered Oligohydramnios	Oligohydramnios, Antepartum Condition Or Complication
Deficient Liquor	Oligohydramnios, Unspecified Trimester
Reduced Liquor Volume

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-126073	DFP00173		99.59%	否
HY-126074	Z433927330		98.11%	否
HY-RS00879	AQP7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	AQP7	RGD	RGD:2145
Mus musculus	AQP7	MGD	MGI:1314647

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

AQP7 - aquaporin 7 Gene

关于 AQP7

功能概要

AQP7 基因产物(7)

AQP7 蛋白结构

AQP7 蛋白互作信息

关联疾病

直系同源

热门区域

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AQP7 - aquaporin 7 Gene

关于 AQP7

功能概要

AQP7 基因产物(7)

AQP7 蛋白结构

AQP7 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z