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  3. Rorc - RAR-related orphan receptor C Gene

Rorc - RAR-related orphan receptor C Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：RAR 相关孤儿受体 C

种属: Rattus norvegicus

基因 ID: 368158 | 基因类型: protein coding

关于 Rorc

Primary_assembly 2: 182,009,286-182,034,907 forward strand.mRatBN7.2:CM026975.1

This gene has 4 transcripts (splice variants), 383 orthologues, 19 paralogues and is associated with 13 phenotypes. Biased expression in Thymus (RPKM 399.9), Liver (RPKM 124.) and 5 other tissues.

功能概要

预计该基因编码的蛋白可启动多种功能，包括 DNA 结合转录因子活性、RNA 聚合酶 II 特异性；氧固醇结合活性；和转录辅激活因子结合活性。参与昼夜节律。预计位于质膜和核体的外侧。预计活跃于核心。该基因与免疫缺陷 42 相关的人类直向同源基因。与人类 RORC（RAR 相关孤儿受体 C）直向同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; oxysterol binding activity; and transcription coactivator binding activity. Involved in circadian rhythm. Predicted to be located in external side of plasma membrane and nuclear body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 42. Orthologous to human RORC (RAR related Orphan Receptor C). [provided by Alliance of Genome Resources, Apr 2022]

Rorc 基因产物(4)

mRNA Protein Name
XM_017591313.2 XP_017446802.1 nuclear receptor ROR-gamma isoform X2
XM_039103783.1 XP_038959711.1 nuclear receptor ROR-gamma isoform X3
XM_006232926.4 XP_006232988.2 nuclear receptor ROR-gamma isoform X1
XM_039103784.1 XP_038959712.1 nuclear receptor ROR-gamma isoform X4
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in circadian rhythm IEP
IEP: 通过表达模式推断
15781226 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Rorc 蛋白结构

NR_DBD_ROR

NR_DBD_ROR: cd06968 (23 - 117)

NR_LBD_ROR_like

NR_LBD_ROR_like: cd06939 (257 - 495)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
蛋白主名 其他名称

nuclear receptor ROR-gamma

RAR-related orphan receptor gamma

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-19775 GNE-6468 Antagonist 98.04% 否
HY-112706 PF-06747711 Antagonist 99.86% 否
HY-19774 GNE-0946 Inhibitor 98.09% 否
HY-128353 ROR agonist-1 Antagonist / 否
HY-148237 JNJ-54119936 Antagonist / 否
HY-16983 GNE-3500 Antagonist / 否
HY-RS12132 RORC Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12133 Rorc Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12134 Rorc Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rorc NCBI NCBI:6097
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