1. Gene
  2. GSTK1 - glutathione S-transferase kappa 1 Gene

GSTK1 - glutathione S-transferase kappa 1 Gene

中文名称:谷胱甘肽 S-转移酶 kappa 1

种属: Homo sapiens

同用名: GST; GST13; hGSTK1; GSTK1-1; GST13-13; GST 13-13

基因 ID: 373156 | 基因类型: protein coding

关于 GSTK1

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:143,263,441-143,269,115 (from NCBI)

This gene has 9 transcripts (splice variants) and 226 orthologues. Ubiquitous expression in duodenum (RPKM 118.1), small intestine (RPKM 106.3) and 25 other tissues.

功能概要

该基因编码谷胱甘肽转移酶超家族的 kappa 类成员,该酶在细胞解毒中发挥作用。编码的蛋白质定位于过氧化物酶体并催化谷胱甘肽与广泛的疏水亚基结合,促进这些化合物从细胞中去除。可变剪接导致多个转录变体。[RefSeq 提供,2009 年 1 月]

This gene encodes a member of the kappa class of the glutathione transferase superfamily of Enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

GSTK1 基因产物(4)

mRNA Protein Name
NM_001143679.2 NP_001137151.1 glutathione S-transferase kappa 1 isoform b
NM_001143680.2 NP_001137152.1 glutathione S-transferase kappa 1 isoform c
NM_001143681.2 NP_001137153.1 glutathione S-transferase kappa 1 isoform d
NM_015917.3 NP_057001.1 glutathione S-transferase kappa 1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glutathione peroxidase activity IDA
IDA: 通过直接分析推断
14742434 GOA
enables glutathione transferase activity IDA
IDA: 通过直接分析推断
14742434 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19011089 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in epithelial cell differentiation IEP
IEP: 通过表达模式推断
21492153 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in peroxisome IDA
IDA: 通过直接分析推断
14742434 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GSTK1 蛋白结构

DSBA

DSBA: DSBA-like thioredoxin domain (7 - 210)

  • 0
  • 100
  • 200
  • 226 a.a.
蛋白主名 其他名称

glutathione S-transferase kappa 1

GST class-kappa

重组 GSTK1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75800 GSTK1 Protein, Human Q9Y2Q3-1 (G2-L226) ≥95%
HY-P700381 Glutathione S-transferase kappa 1/GSTK1 Protein, Human (GST) Q9Y2Q3-1 (G2-L226) ≥95%

直系同源

种属 基因名 来源 基因 ID
Bos taurus GSTK1 VGNC VGNC:29685
Rattus norvegicus GSTK1 RGD RGD:735188
Mus musculus GSTK1 MGD MGI:1923513
Macaca mulatta GSTK1 VGNC VGNC:73180
Felis catus GSTK1 VGNC VGNC:62730
Others GSTK1 NCBI