2. Gene
  3. KRT77 - keratin 77 Gene

KRT77 - keratin 77 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：角蛋白 77

种属: Homo sapiens

同用名: K1B; KRT1B

基因 ID: 374454 | 基因类型: protein coding

关于 KRT77

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,689,626-52,703,524 (from NCBI)

This gene has 3 transcripts (splice variants), 79 orthologues and 68 paralogues. Restricted expression toward skin (RPKM 121.1).

功能概要

角蛋白是负责上皮细胞结构完整性的中间丝蛋白，分为上皮角蛋白和毛发角蛋白。该基因编码一种在皮肤和小汗腺中表达的上皮角蛋白。 II 型角蛋白聚集在染色体 12q13 的区域。[RefSeq 提供，2009 年 6 月]

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes an epithelial keratin that is expressed in the skin and eccrine sweat glands. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

KRT77 基因产物(1)

mRNA Protein Name
NM_175078.3 NP_778253.2 keratin, type II cytoskeletal 1b

KRT77 蛋白结构

Filament

Filament: Intermediate filament protein (163 - 476)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 578 a.a.
蛋白主名 其他名称

keratin, type II cytoskeletal 1b

CK-1B

KRT77 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra KRT77 Q7Z794 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra KRT77 Q7Z794 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra KRT77 Q7Z794 KRT35 Homo sapiens Q92764
Validated Y2H
32296183
Intra KRT77 Q7Z794 KRT36 Homo sapiens O76013-2
Y2H Prey Pooling
32296183
Intra KRT77 Q7Z794 KRT36 Homo sapiens O76013-2
Y2H Array
32296183
Intra KRT77 Q7Z794 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra KRT77 Q7Z794 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra KRT77 Q7Z794 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra KRT77 Q7Z794 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra KRT77 Q7Z794 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra KRT77 Q7Z794 KRT15 Homo sapiens P19012
Y2H Prey Pooling
32296183
Intra KRT77 Q7Z794 KRT15 Homo sapiens P19012
Y2H Array
32296183
Intra KRT77 Q7Z794 KRT19 Homo sapiens P08727
Y2H Prey Pooling
32296183
Intra KRT77 Q7Z794 KRT19 Homo sapiens P08727
Y2H Array
32296183
Intra KRT77 Q7Z794 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra KRT77 Q7Z794 KRT31 Homo sapiens Q15323
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Aggressive Digital Papillary Adenocarcinoma
Macular Degeneration, Age-Related, 13

Age Related Macular Degeneration 13

ARMD13

Macular Degeneration, Age-Related, 13, Susceptibility To

Macular Degeneration, Age-Related, Type 13
Palmoplantar Keratoderma, Epidermolytic

Epidermolytic Palmoplantar Keratoderma

EPPK

Keratosis Palmaris Et Plantaris Familiaris

Tylosis

Keratosis Of Greither

Diffuse Nonepidermolytic Palmoplantar Keratoderma

Keratoderma, Palmoplantar, Epidermolytic

Unna-Thost Palmoplantar Keratoderma

Epidermolytic Palmoplantar Keratoderma Of Voerner

Ppke

Keratoderma, Epidermolytic Palmoplantar

Palmoplantar Keratoderma, Vorner Type

Hyperkeratosis, Localized Epidermolytic

Diffuse Erythrodermic Palmoplantar Keratoderma, Vörner Type

Epidermolytic Palmoplantar Keratoderma Of Vörner

Hyperkeratosis Palmoplantar Localized Epidermolytic

Diffuse Neppk

Ppk Diffusa Circumscripta

Thost-Unna Disease

Thost-Unna Palmoplantar Keratoderma

Diffuse Erythrodermic Palmoplantar Keratoderma, Voerner Type

Diffuse Erythrodermic Palmoplantar Keratoderma, Vorner Type

Epidermolytic Palmoplantar Keratoderma Of Vorner

Ehppk

Epidermolytic Unna-Thost Disease

Localized Epidermolytic Hyperkeratosis

Palmoplantar Keratoderma Vorner Type

Unilateral Palmoplantar Verrucous Nevus

UPVN

Keratoderma, Palmoplantar, Diffuse

Hyperkeratosis

Palmoplantar Keratoderma, Nonepidermolytic

Epidermolytic Palmoplantar Keratoderma Vorner Type

Type B Tylosis

Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas

Type A Tylosis
Osteogenesis Imperfecta, Type Iv

Osteogenesis Imperfecta Type 4

Osteogenesis Imperfecta Type Iv

OI4

Oi, Type Iv

Osteogenesis Imperfecta With Normal Sclerae

Oi Type Iv

Oi Type 4

Osteogenesis Imperfecta With Normal Sclera

Common Variable Oi With Normal Sclerae

Osteogenesis Imperfecta 4

Oi-Iv
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07464 KRT77 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus KRT77 RGD RGD:1302968
Mus musculus KRT77 MGD MGI:3588209
Bos taurus KRT77 VGNC VGNC:50406
Felis catus KRT77 VGNC VGNC:84051
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