KLRD1 - killer cell lectin like receptor D1 Gene

中文名称：杀伤细胞凝集素样受体 D1

种属: Homo sapiens

同用名: CD94

基因 ID: 3824 | 基因类型: protein coding

关于 KLRD1

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,238,961-10,329,608 (from NCBI)

This gene has 11 transcripts (splice variants), 394 orthologues and 23 paralogues. Broad expression in spleen (RPKM 3.3), lung (RPKM 0.9) and 15 other tissues.

功能概要

自然杀伤 (NK) 细胞是一种独特的淋巴细胞谱系，可介导细胞毒活性并在免疫刺激后分泌细胞因子。 C 型凝集素超家族的几个基因，包括 NKG2 家族的成员，由 NK 细胞表达，可能参与 NK 细胞功能的调节。 KLRD1 (CD94) 是一种优先在 NK 细胞上表达的抗原，由于其具有外部 C 末端而被归类为 II 型膜蛋白。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2017 年 5 月]

Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]

KLRD1 基因产物(8)

mRNA	Protein	Name
NM_001114396.3	NP_001107868.2	natural killer cells antigen CD94 isoform 1
NM_001351060.2	NP_001337989.1	natural killer cells antigen CD94 isoform 3
NM_001351062.2	NP_001337991.1	natural killer cells antigen CD94 isoform 1
NM_001351063.2	NP_001337992.1	natural killer cells antigen CD94 isoform 4
NM_001414224.1	NP_001401153.1	natural killer cells antigen CD94 isoform 5
NM_001414225.1	NP_001401154.1	natural killer cells antigen CD94 isoform 6
NM_002262.5	NP_002253.2	natural killer cells antigen CD94 isoform 1
NM_007334.3	NP_031360.1	natural killer cells antigen CD94 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables HLA-E specific inhibitory MHC class Ib receptor activity	IDA IDA: 通过直接分析推断	9486650	GOA
enables MHC class I protein complex binding	IPI IPI: 通过物理相互作用推断	18448674	GOA
enables MHC class Ib protein binding, via antigen binding groove	IPI IPI: 通过物理相互作用推断	25631937	GOA
enables protein antigen binding	IDA IDA: 通过直接分析推断	18448674	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	8046333	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in natural killer cell mediated immunity	IDA IDA: 通过直接分析推断	18448674	GOA
involved in negative regulation of T cell mediated cytotoxicity	IDA IDA: 通过直接分析推断	9485206	GOA
involved in negative regulation of natural killer cell mediated cytotoxicity	IDA IDA: 通过直接分析推断	9486650	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity	IDA IDA: 通过直接分析推断	9754572	GOA
involved in stimulatory C-type lectin receptor signaling pathway	IDA IDA: 通过直接分析推断	9655483	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	9485206	GOA
part of receptor complex	IDA IDA: 通过直接分析推断	18448674	GOA
part of receptor complex	IPI IPI: 通过物理相互作用推断	18448674	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KLRD1 蛋白结构

Lectin_C

0
100
179 a.a.

蛋白主名

其他名称

natural killer cells antigen CD94

CD94 antigen

重组 KLRD1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70713	NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Flag)	P26715 (R100-L233)&Q13241 (S34-I179)	≥95%
HY-P72700	CD94 Protein, Human (HEK293, His)	Q13241-1 (S34-I179)	≥95%
HY-P77803	NKG2A-CD94 Heterodimer Protein, Human (HEK293, Fc-Flag)	P26715 (R100-L233)&Q13241 (S34-I179)	≥95%
HY-P77804	NKG2A-CD94 Heterodimer Protein, Human (HEK293, mFc)	P26715 (R100-L233)&Q13241 (S34-I179)	≥95%
HY-P77805	NKG2A-CD94 Heterodimer Protein, Human (HEK293, His-Avi)	P26715 (R100-L233)&Q13241 (S34-I179)	≥95%
HY-P77806	NKG2A-CD94 Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi)	P26715 (R100-L233)&Q13241 (S34-I179)	≥95%
HY-P77807	NKG2C-CD94 Heterodimer Protein, Human (HEK293, His-Avi)	P26717 (E98-L231)&Q13241 (S34-I179)	≥95%
HY-P78097	CD94 Protein, Human (Biotinylated, HEK293, His-Avi)	Q13241-1 (S34-I179)	≥95%
HY-P78421	CD94 Protein, Human (HEK293, His-Avi)	Q13241-1 (S34-I179)	≥95%

关联疾病

疾病名称

别名

Nk Cell Deficiency

Chronic Nk-Cell Lymphocytosis

Nk-Cell Large Granular Lymphocyte Lymphocytosis

Chronic Lymphoproliferative Disorder Of Nk-Cells

Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections

Aggressive Nk-Cell Leukemia

Aggressive Nk-Cell Leukaemia	Large Granular Lymphocyte Leukemia, Nk-Cell Type
Natural Killer Cell Leukaemia	Natural Killer Cell Leukemia
Aggressive Nk Cell Leukemia	Ankl
Aggressive Natural Killer Cell Leukemia	Ankcl
Aggressive Nk-Cell Lymphoma	Nk-Cell Lgl Leukemia
Nk-Cell Large Granular Lymphocyte Leukemia	Abnormality Of The Ankles
Aggressive Natural Killer-Cell Leukemia	Leukemia, Large Granular Lymphocytic
Leukemia, Natural Killer Cell Large Granular Lymphocytic

Psoriasis

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Ceftazidime Allergy

Fortaz Allergy

Tazicef Allergy

Parotid Gland Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Parotid Gland

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

Bare Lymphocyte Syndrome, Type I

Hla Class I Deficiency	Mhc Class I Deficiency
Bls, Type I	Bare Lymphocyte Syndrome Type I
Bare Lymphocyte Syndrome, Type I, Due To Tap2 Deficiency	Blsi
Mhc Class 1 Deficiency	Major Histocompatibility Complex Class 1 Deficiency
Bare Lymphocyte Syndrome 1	BLS1
Bls I	Bls Type I
Bl-1	Bare Lymphocyte Syndrome Type 1
Immunodeficiency By Defective Expression Of Hla - [Human Leukocyte Antigen] Class 1	Scid - [Severe Combined Immunodeficiency] Due To Absent Class 2 Hla Antigens
Bls - [Bare Lymphocyte Syndrome] Nos

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07395	KLRD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	KLRD1	VGNC	VGNC:42486
Macaca mulatta	KLRD1	VGNC	VGNC:100068
Mus musculus	KLRD1	MGD	MGI:1196275
Rattus norvegicus	KLRD1	RGD	RGD:2978
Others	KLRD1	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2024 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KLRD1 - killer cell lectin like receptor D1 Gene

关于 KLRD1

功能概要

KLRD1 基因产物(8)

KLRD1 蛋白结构

重组 KLRD1 蛋白

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

KLRD1 - killer cell lectin like receptor D1 Gene

关于 KLRD1

功能概要

KLRD1 基因产物(8)

KLRD1 蛋白结构

重组 KLRD1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z