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  2. Hcrtr2 - hypocretin (orexin) receptor 2 Gene

Hcrtr2 - hypocretin (orexin) receptor 2 Gene

中文名称:伪君子 (食欲素) 受体 2

种属: Mus musculus

同用名: OX2R; OXR2; OX2aR; OX2bR; mOXR2; mOX2aR; mOX2bR

基因 ID: 387285 | 基因类型: protein coding

关于 Hcrtr2

Chromosome 9: 76,133,162-76,231,138 reverse strand.GRCm39:CM001002.3

This gene has 3 transcripts (splice variants), 199 orthologues, 16 paralogues and is associated with 8 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白可启动食欲素受体活性。作用于磷脂酶 C 激活 G 蛋白偶联受体信号通路的上游或内部。预测位于质膜中。预计是膜的组成部分。预计是质膜的组成部分。以多种结构表达,包括大脑;泌尿生殖系统;肝;肺;和脾脏。用于研究发作性睡病。与人类 HCRTR2(伪君子受体 2)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables orexin receptor activity. Acts upstream of or within Phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Used to study narcolepsy. Orthologous to human HCRTR2 (hypocretin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Hcrtr2 基因产物(2)

mRNA Protein Name
NM_198962.4 NP_945200.1 orexin receptor type 2 isoform 1
NM_001364551.1 NP_001351480.1 orexin receptor type 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables orexin receptor activity IDA
IDA: 通过直接分析推断
15256537 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
22028875 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in locomotion IGI
IGI: 通过遗传相互作用推断
27585848 MGI
acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
15256537 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Hcrtr2 蛋白结构

7tmA_OXR

7tmA_OXR: cd15208 (54 - 374)

7tmA_OXR

7tmA_OXR: cd15208 (55 - 81)

7tmA_OXR

7tmA_OXR: cd15208 (88 - 114)

7tmA_OXR

7tmA_OXR: cd15208 (126 - 156)

7tmA_OXR

7tmA_OXR: cd15208 (167 - 188)

7tmA_OXR

7tmA_OXR: cd15208 (219 - 248)

7tmA_OXR

7tmA_OXR: cd15208 (296 - 326)

7tmA_OXR

7tmA_OXR: cd15208 (342 - 367)

Orexin_rec2

Orexin_rec2: pfam03827 (385 - 442)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 460 a.a.
蛋白主名 其他名称

orexin receptor type 2

hypocretin receptor type 2

orexin receptor type-2a

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hcrtr2 NCBI NCBI:3062