2. Gene
  3. Zhx2 - zinc fingers and homeoboxes 2 Gene

Zhx2 - zinc fingers and homeoboxes 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：锌指和同源盒 2

种属: Mus musculus

同用名: Raf; Afr1; Afr-1; mKIAA0854

基因 ID: 387609 | 基因类型: protein coding

关于 Zhx2

Chromosome 15: 57,558,061-57,703,228 forward strand.GRCm39:CM001008.3

This gene has 2 transcripts (splice variants), 237 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in genital fat pad adult (RPKM 5.9), spleen adult (RPKM 5.8) and 28 other tissues.

功能概要

预测该基因编码的蛋白编码的蛋白可启动 DNA 结合转录因子活性，RNA 聚合酶 II 特异性；蛋白质异二聚化活性；和蛋白质同二聚化活性。参与视网膜双极神经元分化。作用于大分子代谢过程的上游或负调控；神经元分化的负调节；和成体干细胞群的维持。在细胞核中活跃。在大脑中表达；肝;和肾血管系统。与人类 ZHX2（锌指和同源框 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; protein heterodimerization activity; and protein homodimerization activity. Involved in retinal bipolar neuron differentiation. Acts upstream of or within negative regulation of macromolecule metabolic process; negative regulation of neuron differentiation; and somatic stem cell population maintenance. Is active in nucleus. Is expressed in brain; liver; and renal vasculature. Orthologous to human ZHX2 (zinc fingers and homeoboxes 2). [provided by Alliance of Genome Resources, Apr 2022]

Zhx2 基因产物(1)

mRNA Protein Name
NM_199449.2 NP_955520.1 zinc fingers and homeoboxes protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
8939998 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within mRNA catabolic process IDA
IDA: 通过直接分析推断
1370712 MGI
acts upstream of or within negative regulation of neuron differentiation IDA
IDA: 通过直接分析推断
19515908 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19515908 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
10673330 MGI
acts upstream of neuron differentiation IDA
IDA: 通过直接分析推断
19515908 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
7523852 MGI
involved in retinal bipolar neuron differentiation IMP
IMP: 通过突变表型推断
30146259 MGI
acts upstream of or within somatic stem cell population maintenance IDA
IDA: 通过直接分析推断
19515908 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in nucleus IDA
IDA: 通过直接分析推断
17056598 MGI
located in nucleus IDA
IDA: 通过直接分析推断
19515908 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Zhx2 蛋白结构

zf_C2H2_ZHX

zf_C2H2_ZHX: pfam18387 (105 - 157)

homeodomain

homeodomain: cd00086 (271 - 320)

homeodomain

homeodomain: cd00086 (443 - 495)

HOX

HOX: smart00389 (536 - 581)

homeodomain

homeodomain: cd00086 (635 - 683)

  • 0
  • 200
  • 400
  • 600
  • 836 a.a.
蛋白主名 其他名称

zinc fingers and homeoboxes protein 2

AFP regulator 1

alpha fetoprotein regulation 1, adult

alpha-fetoprotein regulator 1

regulator of AFP

zinc finger and homeodomain protein 2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16069 ZHX2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS16070 Zhx2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS16071 Zhx2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Zhx2 NCBI NCBI:22882
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