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  2. GFRAL - GDNF family receptor alpha like Gene

GFRAL - GDNF family receptor alpha like Gene

中文名称:GDNF 家族受体α样

种属: Homo sapiens

同用名: GRAL; UNQ9356; C6orf144; bA360D14.1

基因 ID: 389400 | 基因类型: protein coding

关于 GFRAL

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:55,327,469-55,402,493 (from NCBI)

This gene has 1 transcript (splice variant), 174 orthologues and 4 paralogues. Low expression observed in reference dataset.

功能概要

启用神经胶质细胞衍生的神经营养因子受体活性和受体酪氨酸激酶结合活性。参与胶质细胞源性神经营养因子受体信号通路; MAPK 级联的正调控;蛋白激酶 B 信号的正调控。位于质膜外侧。 [由基因组资源联盟提供,2022 年 4 月]

Enables glial cell-derived neurotrophic factor receptor activity and receptor tyrosine kinase binding activity. Involved in glial cell-derived neurotrophic factor receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of protein kinase B signaling. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GFRAL 基因产物(1)

mRNA Protein Name
NM_207410.2 NP_997293.2 GDNF family receptor alpha-like precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glial cell-derived neurotrophic factor receptor activity IDA
IDA: 通过直接分析推断
28846097 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28846097 GOA
enables receptor tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
28846097 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in GDF15-GFRAL signaling pathway IDA
IDA: 通过直接分析推断
28953886 GOA
involved in positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
28846099 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
28846097 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
28953886 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

GFRAL 蛋白结构

GDNF

GDNF: GDNF/GAS1 domain (131 - 210)

GDNF

GDNF: GDNF/GAS1 domain (220 - 316)

  • 0
  • 100
  • 200
  • 300
  • 394 a.a.
蛋白主名 其他名称

GDNF family receptor alpha-like

IVFI9356

重组 GFRAL 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71580 GFRAL Protein, Human (His-SUMO) Q6UXV0 (S19-E351) ≥95%
HY-P78135 GFRAL Protein, Human (Biotinylated, HEK293, His-Avi) Q6UXV0 (S19-E351) ≥95%
HY-P78449 GFRAL Protein, Human (HEK293, His-Avi) Q6UXV0 (S19-E351) ≥95%

直系同源

种属 基因名 来源 基因 ID
Felis catus GFRAL VGNC VGNC:62532
Rattus norvegicus GFRAL RGD RGD:1565220
Macaca mulatta GFRAL VGNC VGNC:104386
Canis familiaris GFRAL VGNC VGNC:41192
Bos taurus GFRAL VGNC VGNC:53972
Mus musculus GFRAL MGD MGI:3607786
Macaca fascicularis GFRAL NCBI NCBI:102126381
Others GFRAL NCBI