2. Gene
  3. AGMO - alkylglycerol monooxygenase Gene

AGMO - alkylglycerol monooxygenase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：烷基甘油单加氧酶

种属: Homo sapiens

同用名: TMEM195

基因 ID: 392636 | 基因类型: protein coding

关于 AGMO

Cytogenetic location: 7p21.2 Genomic coordinates (GRCh38): 7:15,117,223-15,562,015 (from NCBI)

This gene has 4 transcripts (splice variants) and 204 orthologues. Biased expression in liver (RPKM 8.7), small intestine (RPKM 2.1) and 4 other tissues.

功能概要

该基因编码的蛋白质是一种四氢生物蝶呤和铁依赖性酶，可裂解烷基甘油的醚键。序列比较将该蛋白质区分为形成第三类不同的四氢生物蝶呤依赖性酶。该基因的变异与葡萄糖刺激的胰岛素反应降低、2 型糖尿病和颅内动脉瘤易感性有关。[RefSeq 提供，2012 年 8 月]

The protein encoded by this gene is a tetrahydrobiopterin- and iron-dependent Enzyme that cleaves the ether bond of alkylglycerols. Sequence comparisons distinguish this protein as forming a third, distinct class of tetrahydrobiopterin-dependent Enzymes. Variations in this gene have been associated with decreased glucose-stimulated Insulin response, type 2 diabetes, and susceptibility to intracranial aneurysms. [provided by RefSeq, Aug 2012]

AGMO 基因产物(1)

mRNA Protein Name
NM_001004320.2 NP_001004320.1 alkylglycerol monooxygenase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glyceryl-ether monooxygenase activity IDA
IDA: 通过直接分析推断
20643956 GOA
enables iron ion binding IMP
IMP: 通过突变表型推断
20643956 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ether lipid metabolic process IDA
IDA: 通过直接分析推断
20643956 GOA
involved in membrane lipid metabolic process IDA
IDA: 通过直接分析推断
20643956 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
20643956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AGMO 蛋白结构

FA_hydroxylase

FA_hydroxylase: Fatty acid hydroxylase superfamily (119 - 225)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 445 a.a.
蛋白主名 其他名称

alkylglycerol monooxygenase

glyceryl-ether monooxygenase

AGMO 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
AGMO Q6ZNB7 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
种属内
AGMO Q6ZNB7 AQP6 Homo sapiens Q13520
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency

Sepiapterin Reductase Deficiency

Spr Deficiency

Dopa-Responsive Dystonia Due To Sepiapterin Reductase Deficiency

Srd

Drd Due To Srd

Dopa-Responsive Hypersomnia

Dyt-Spr

Dyt/Park-Spr

Sr-Deficient Drd

Autosomal Recessive Sepiapterin Reductase-Deficient Drd

Spr

DRDSPRD

Motor And Cognitive Disorder Due To Sepiapterin Reductase Deficiency

Psychomotor Disorders
Sjogren-Larsson Syndrome

Sjögren-Larsson Syndrome

SLS

Faldh Deficiency

Fatty Aldehyde Dehydrogenase Deficiency

Fatty Acid Alcohol Oxidoreductase Deficiency

Ichthyosis, Spastic Neurologic Disorder, And Oligophrenia

Sjogren Larsson Syndrome

Fatty Alcohol:Nad+ Oxidoreductase Deficiency

Sjogren-Larsson'S Syndrome

Fadh Deficiency

Fao Deficiency

Congenital Icthyosis Mental Retardation Spasticity Syndrome

Ichthyosis Oligophrenia Syndrome

Sjoegren-Larsson Syndrome
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00451 AGMO Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris AGMO VGNC VGNC:37706
Bos taurus AGMO VGNC VGNC:25731
Felis catus AGMO VGNC VGNC:59684
Mus musculus AGMO MGD MGI:2442495
Rattus norvegicus AGMO RGD RGD:1312038
Macaca mulatta AGMO VGNC VGNC:69754
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