ARHGAP4 - Rho GTPase activating protein 4 Gene

中文名称：Rho GTP 酶激活蛋白 4

种属: Homo sapiens

同用名: C1; RGC1; p115; SrGAP4; RhoGAP4

关于 ARHGAP4

功能概要

该基因编码 rhoGAP 蛋白家族的成员，该蛋白在属于 Ras 超家族的小 GTP 结合蛋白的调节中发挥作用。由大鼠直系同源基因编码的蛋白质定位于高尔基复合体，可以重新分布到微管。大鼠蛋白在体外刺激某些 Rho GTP 酶的活性。在肾源性尿崩症患者中发现了该基因和邻近基因的基因组缺失。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 9 月]

This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the Ras superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]