LCN1 - lipocalin 1 Gene

中文名称：脂质运载蛋白 1

种属: Homo sapiens

同用名: TP; TLC; PMFA; VEGP

关于 LCN1

功能概要

该基因编码小分泌蛋白脂质运载蛋白家族的成员。脂质运载蛋白是与多种疏水配体结合的细胞外转运蛋白。编码的蛋白质是眼泪中的主要脂质结合蛋白，并且会因感染和压力等多种刺激而过量产生。所编码的蛋白质可能是染色体非整倍体的标记以及干燥综合征中的自身抗原。已观察到该基因编码多种亚型的可变剪接转录变体，该基因的两个假基因也位于 9 号染色体的长臂上。[RefSeq 提供，2011 年 11 月]

This gene encodes a member of the lipocalin family of small secretory proteins. Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. The encoded protein is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including Infection and stress. The encoded protein may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and two pseudogenes of this gene are also located on the long arm of chromosome 9. [provided by RefSeq, Nov 2011]