LCP1 - lymphocyte cytosolic protein 1 Gene

中文名称：淋巴细胞胞质蛋白 1

种属: Homo sapiens

同用名: LPL; CP64; PLS2; LC64P; HEL-S-37; L-PLASTIN

关于 LCP1

功能概要

Plastins 是一个肌动蛋白结合蛋白家族，在整个真核生物进化过程中都是保守的，并在高等真核生物的大多数组织中表达。在人类中，已鉴定出两种普遍存在的塑化蛋白亚型 (L 和 T) 。 Plastin 1 (也称为 Fimbrin) 是第三种不同的 Plastin 亚型，它在小肠中以高水平特异性表达。 L 同种型仅在造血细胞谱系中表达，而 T 同种型已在具有复制潜力的实体组织的所有其他正常细胞 (成纤维细胞、内皮细胞、上皮细胞、黑素细胞等) 中发现。然而，已经在许多类型的非造血来源的恶性人类细胞中发现了 L-plastin，这表明它的表达是伴随实体组织中的肿瘤发生而被诱导的。[RefSeq 提供，2008 年 7 月]

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all Other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues. [provided by RefSeq, Jul 2008]