1. Gene
  2. SHC4 - SHC adaptor protein 4 Gene

SHC4 - SHC adaptor protein 4 Gene

中文名称:SHC 衔接蛋白 4

种属: Homo sapiens

同用名: RaLP; SHCD

基因 ID: 399694 | 基因类型: protein coding

关于 SHC4

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:48,823,741-48,963,919 (from NCBI)

This gene has 6 transcripts (splice variants), 179 orthologues and 3 paralogues. Biased expression in testis (RPKM 6.4), brain (RPKM 2.8) and 5 other tissues.

功能概要

预测可启用受体酪氨酸激酶结合活性。预测参与跨膜受体蛋白酪氨酸激酶信号通路。预计在几个过程的上游或内部起作用,包括细胞凋亡过程;细胞群增殖的正向调节;和干细胞分化。预测位于突触后膜。预计在质膜上有活性。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including apoptotic process; positive regulation of cell population proliferation; and stem cell differentiation. Predicted to be located in postsynaptic membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SHC4 基因产物(1)

mRNA Protein Name
NM_203349.4 NP_976224.3 SHC-transforming protein 4
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24658140 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SHC4 蛋白结构

PID

PID: Phosphotyrosine interaction domain (PTB/PID) (192 - 347)

SH2

SH2: SH2 domain (527 - 597)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 630 a.a.
蛋白主名 其他名称

SHC-transforming protein 4

SH2 domain protein C4

SHC4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SHC4 Q6S5L8 MET Homo sapiens P08581
FPS
24728074
种属内
SHC4 Q6S5L8 EGFR Homo sapiens P00533
Ub Reconstruction
24658140
种属内
SHC4 Q6S5L8 AR Homo sapiens P10275
FPS
24728074
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Obsessive-Compulsive Personality Disorder

Anankastic Personality Disorder

Obsessive-Compulsive Personality

Compulsive Personality Disorder

Ocpd

Obsessional Personality Disorder

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SHC4 MGD MGI:2655364
Rattus norvegicus SHC4 RGD RGD:1583644
Felis catus SHC4 VGNC VGNC:80847
Bos taurus SHC4 VGNC VGNC:106925
Macaca mulatta SHC4 VGNC VGNC:77249
Canis familiaris SHC4 VGNC VGNC:46142