AMTN - amelotin Gene

中文名称：釉蛋白

种属: Homo sapiens

同用名: AI3B; UNQ689

基因 ID: 401138 | 基因类型: protein coding

关于 AMTN

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,518,569-70,532,743 (from NCBI)

This gene has 2 transcripts (splice variants), 91 orthologues and is associated with 2 phenotypes. Biased expression in stomach (RPKM 3.1), prostate (RPKM 1.0) and 1 other tissue.

功能概要

牙齿的矿化部分，即牙本质和牙釉质，分别由间充质衍生的成牙本质细胞和上皮衍生的成釉细胞形成。随着成釉细胞分化，它们会在有机釉质基质中沉积釉质形成所需的特定蛋白质，包括釉原蛋白 (AMELX；MIM 300391) 、釉质蛋白 (ENAM；MIM 606585) 和成釉蛋白 (AMBN；MIM 601259) 。 Amelotin 在成熟阶段的成釉细胞中特异性表达 (Iwasaki 等人，2005 [PubMed 16304441]) 。[OMIM 提供，2008 年 3 月]

The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).[supplied by OMIM, Mar 2008]

AMTN 基因产物(2)

mRNA	Protein	Name
NM_001286731.2	NP_001273660.1	amelotin isoform 2 precursor
NM_212557.4	NP_997722.1	amelotin isoform 1 precursor

蛋白主名

其他名称

amelotin

RSTI689

重组 AMTN 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76725	Amelotin Protein, Human (HEK293, Fc)	Q6UX39-1 (L17-Q209)	≥95%

关联疾病

疾病名称

别名

Amelogenesis Imperfecta, Type Iiib

Amelogenesis Imperfecta Type 3b	AI3B
Amelogenesis Imperfecta 3b

Amelogenesis Imperfecta, Type Iiia

Ai3	Adhcai
Amelogenesis Imperfecta Type 3	AI3A
Amelogenesis Imperfecta, Type Iii	Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant
Amelogenesis Imperfecta Type 3a	Amelogenesis Imperfecta Hypomineralization Type
Amelogenesis Imperfecta Type Iii	Hypocalcified Amelogenesis Imperfecta
Amelogenesis Imperfecta, Type 3	Amelogenesis Imperfecta, Hypomineralization Type
Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type	Amelogenesis Imperfecta 3a
Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Amelogenesis Imperfecta, Type Iiic

AI3C	Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Recessive
Amelogenesis Imperfecta Type 3c	Amelogenesis Imperfecta, Type 3c
Amelogenesis Imperfecta Type Iiic	Autosomal Recessive Amelogenesis Imperfecta Hypocalcification Type
Amelogenesis Imperfecta 3c

Amelogenesis Imperfecta, Type Iv

AI4	Aihht
Amelogenesis Imperfecta Type 4	Hypomaturation-Hypoplastic Amelogenesis Imperfecta With Taurodontism
Amelogenesis Imperfecta, Hypomaturation-Hypoplastic Type, With Taurodontism	Amelogenesis Imperfecta Hypomaturation-Hypoplastic Type With Taurodontism
Amelogenesis Imperfecta 4	Ait
Amelogenesis Imperfecta 2 Hypocalcification Type	Amelogenesis Imperfecta Hypomineralization Type
Amelogenesis Imperfecta Type Iv	Amelogenesis Imperfecta With Taurodontism

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2

X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 2	Enamel Hypoplasia, X-Linked
Aih3	Amelogenesis Imperfecta 3, Hypoplastic Type, Formerly
Aih3, Formerly	Amelogenesis Imperfecta, Type Ie, X-Linked 2
Amelogenesis Imperfecta Type Ie X-Linked 2	Amelogenesis Imperfecta 3 Hypoplastic Type
X-Linked Enamel Hypoplasia	Amelogenesis Imperfecta 3, Hypoplastic Type
Amelogenesis Imperfecta-3, Hypoplastic Type	Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1

Dental Fluorosis

Mottled Teeth	Intrinsic Enamel Discolouration Of Fluorosis
Mottling Of Enamel	Fluorosis, Dental
Dental Fluorosis, Acquired

Amelogenesis Imperfecta, Hypomaturation Type, Iia2

Amelogenesis Imperfecta Hypomaturation Type 2a2	AI2A2
Amelogenesis Imperfecta, Type Iia2	Amelogenesis Imperfecta Pigmented Hypomaturation Type 2
Amelogenesis Imperfecta, Pigmented Hypomaturation Type, 2	Amelogenesis Imperfecta Hypomaturation Type Iia2
Amelogenesis Imperfecta Type Iia2	Amelogenesis Imperfecta, Hypomaturation Type, 2a2
Amelogenesis Imperfecta 2 Hypocalcification Type

Amelogenesis Imperfecta, Hypomaturation Type, Iia5

Amelogenesis Imperfecta Hypomaturation Type 2a5	AI2A5
Amelogenesis Imperfecta, Type Iia5	Amelogenesis Imperfecta Hypomaturation Type Iia5
Amelogenesis Imperfecta Type Iia5	Amelogenesis Imperfecta, Hypomaturation Type, 2a5

Amelogenesis Imperfecta, Hypomaturation Type, Iia3

Amelogenesis Imperfecta Hypomaturation Type 2a3	AI2A3
Amelogenesis Imperfecta Hypomaturation Type Iia3	Amelogenesis Imperfecta, Type Iia3
Amelogenesis Imperfecta Type Iia3	Amelogenesis Imperfecta, Hypomaturation Type, 2a3

Teeth Hard Tissue Disease

Amelogenesis Imperfecta, Type Ib

AI1B	Aih2
Amelogenesis Imperfecta Type 1b	Amelogenesis Imperfecta Type Ib
Hereditary Localized Enamel Hypoplasia	Amelogenesis Imperfecta - Hypoplastic Autosomal Dominant - Local
Amelogenesis Imperfecta, Hypoplastic Local, Autosomal Dominant	Enamel Hypoplasia, Hereditary Localized
Autosomal Dominant Hypoplastic Local Amelogenesis Imperfecta	Amelogenesis Imperfecta 1b
Amelogenesis Imperfecta Hypoplastic 2	Amelogenesis Imperfecta Hypoplastic Local Autosomal Dominant

Junctional Epidermolysis Bullosa

Epidermolysis Bullosa, Junctional	Jeb
Epidermolysis Bullosa Atrophicans	Congenital Junctional Epidermolysis Bullosa
Epidermolysis Bullosa Junctional	Junctional Eb - [Epidermolysis Bullosa]
Jeb - [Junctional Epidermolysis Bullosa]	Lucidolytic Epidermolysis Bullosa

Tooth Agenesis

Oligodontia	Hypodontia
Selective Tooth Agenesis	Tooth Agenesis, Selective
Familial Tooth Agenesis	Anodontia
Congenital Absence Of One Tooth

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00671	AMTN Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	AMTN	MGD	MGI:1918671
Canis familiaris	AMTN	VGNC	VGNC:37841
Felis catus	AMTN	VGNC	VGNC:59772
Bos taurus	AMTN	VGNC	VGNC:25876
Rattus norvegicus	AMTN	RGD	RGD:1592356
Macaca mulatta	AMTN	VGNC	VGNC:69750
Others	AMTN	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

AMTN - amelotin Gene

关于 AMTN

功能概要

AMTN 基因产物(2)

重组 AMTN 蛋白

关联疾病

直系同源

热门区域

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AMTN - amelotin Gene

关于 AMTN

功能概要

AMTN 基因产物(2)

重组 AMTN 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z