ARL3 - ADP ribosylation factor like GTPase 3 Gene

中文名称：ADP 核糖基化因子样 GTPase 3

种属: Homo sapiens

同用名: RP83; ARFL3; JBTS35

基因 ID: 403 | 基因类型: protein coding

关于 ARL3

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,673,731-102,714,397 (from NCBI)

This gene has 1 transcript (splice variant), 274 orthologues, 30 paralogues and is associated with 6 phenotypes. Ubiquitous expression in brain (RPKM 13.2), kidney (RPKM 7.9) and 24 other tissues.

功能概要

ADP-核糖基化因子样 3 是 GTP 结合蛋白的 ADP-核糖基化因子家族的成员。 ARL3 结合鸟嘌呤核苷酸但缺乏 ADP-核糖基化因子活性。[RefSeq 提供，2008 年 7 月]

ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity. [provided by RefSeq, Jul 2008]

ARL3 基因产物(1)

mRNA	Protein	Name
NM_004311.4	NP_004302.1	ADP-ribosylation factor-like protein 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GDP binding	IDA IDA: 通过直接分析推断	18588884	GOA
enables GTP binding	IDA IDA: 通过直接分析推断	18588884	GOA
enables microtubule binding	IDA IDA: 通过直接分析推断	12417528	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11847227	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cilium assembly	IMP IMP: 通过突变表型推断	22085962	GOA
involved in mitotic cytokinesis	IMP IMP: 通过突变表型推断	16525022	GOA
acts upstream of or within post-Golgi vesicle-mediated transport	IMP IMP: 通过突变表型推断	20106869	GOA
involved in protein localization to cilium	IMP IMP: 通过突变表型推断	30269812	GOA
involved in small GTPase-mediated signal transduction	IDA IDA: 通过直接分析推断	22085962	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	16525022	GOA
located in centrosome	IDA IDA: 通过直接分析推断	16525022	GOA
NOT located in cilium	IDA IDA: 通过直接分析推断	17646400	GOA
located in cilium	IDA IDA: 通过直接分析推断	16525022	GOA
located in cytoplasmic microtubule	IDA IDA: 通过直接分析推断	12417528	GOA
located in midbody	IDA IDA: 通过直接分析推断	16525022	GOA
located in nucleus	IDA IDA: 通过直接分析推断	16525022	GOA
located in photoreceptor connecting cilium	IDA IDA: 通过直接分析推断	12417528	GOA
located in spindle microtubule	IDA IDA: 通过直接分析推断	16525022	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARL3 蛋白结构

Arf

0
100
182 a.a.

蛋白主名

其他名称

ADP-ribosylation factor-like protein 3

ADP-ribosylation factor-like 3

ARL3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	ARL3	P36405	ARL2BP	Homo sapiens	Q9Y2Y0	TAP	26455799
种属内	ARL3	P36405	ARL2BP	Homo sapiens	Q9Y2Y0	TAP	27173435
种属内	ARL3	P36405	ARL2BP	Homo sapiens	Q9Y2Y0	Validated Y2H	32296183
种属内	ARL3	P36405	UNC119	Homo sapiens	Q13432	Y2H Pooling	16169070
种属内	ARL3	P36405	UNC119	Homo sapiens	Q13432	TAP	27173435
种属内	ARL3	P36405	UNC119	Homo sapiens	Q13432	Validated Y2H	32296183
种属内	ARL3	P36405	UNC119	Homo sapiens	Q13432	TAP	26455799
种属内	ARL3	P36405	UNC119	Homo sapiens	Q13432	FPS	18588884
种属内	ARL3	P36405	UNC119	Homo sapiens	Q13432	GMS	18588884
种属内	ARL3	P36405	PDE6D	Homo sapiens	O43924	TAP	26455799
种属内	ARL3	P36405	PDE6D	Homo sapiens	O43924	Y2H Pooling	16169070
种属内	ARL3	P36405	PDE6D	Homo sapiens	O43924	Anti Tag CoIP	35271311

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Joubert Syndrome 35

JBTS35

Joubert Syndrome, Type 35

Retinitis Pigmentosa 83

RP83	Retinitis Pigmentosa, Type 83

Progressive Cone Dystrophy

Cone Dystrophy

Cone Dystrophy Progressive

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Retinitis Pigmentosa 2

RP2	X-Linked Retinitis Pigmentosa 2
Xlrp2	Xlrp-2
Retinitis Pigmentosa-2	Retinitis Pigmentosa, Type 2

Joubert Syndrome 22

JBTS22

Joubert Syndrome, Type 22

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Renal-Hepatic-Pancreatic Dysplasia

Ivemark'S Syndrome	Ivemark Ii Syndrome
Renohepaticopancreatic Dysplasia

Nephronophthisis 2

NPHP2	Nph2
Nephronophthisis 2, Infantile	Infantile Nephronophthisis 2
Infantile Nephronophthisis	Nephronophthisis, Type 2

Cone-Rod Dystrophy 16

Retinitis Pigmentosa 64	Retinal Dystrophy With Early Macular Involvement
CORD16	RP64

Nephronophthisis

Medullary Cystic Disease	Medullary Cystic Kidney
Nph	Nphp
Kidney Disease, Cystic, Medullary

Cone Dystrophy

Retinal Cone Dystrophy	Dystrophy, Cone
Cone Dystrophy 3

Meckel Syndrome, Type 1

Meckel-Gruber Syndrome	Meckel Syndrome
Dysencephalia Splanchnocystica	Meckel Syndrome 1
MKS1	Mks
Gruber Syndrome	Meckel-Gruber Syndrome, Type 1
Mes	Dysencephalia Splachnocystica
Meckel Gruber Syndrome	Meckel Syndrome Type 1

Visceral Heterotaxy

Situs Ambiguus	Heterotaxia
Heterotaxy Syndrome	Heterotaxy
Lateralization Defect	Situs Ambiguous
Left Isomerism	Htx
Ivemark Syndrome	Right Isomerism
Situs Ambiguus Viscerum	Incomplete Situs Inversus
Partial Situs Inversus	Heterotaxy, Visceral
Asplenia Syndrome	Bilateral Left-Sidedness
Polysplenia Syndrome	Moller Syndrome

Leber Plus Disease

Leber Congenital Amaurosis	Lca
Leber'S Amaurosis	Leber'S Disease
Amaurosis Congenita Of Leber	Amaurosis Congenita Of Leber, Type 1
Lhon Plus Disease	Congenital Absence Of The Rods And Cones
Congenital Retinal Blindness	Crb
Congenital Amaurosis Of Retinal Origin	Leber'S Congenital Amaurosis
Leber Congenital Amaurosis 1	Leber'S Congenital Tapetoretinal Degeneration
Leber'S Congenital Tapetoretinal Dysplasia	Lca1
Leber Congenital Amaurosis Type 1	Retinal Blindness, Congenital
Amaurosis, Leber Congenital	Dysgenesis Neuroepithelialis Retinae
Hereditary Epithelial Dysplasia Of Retina	Hereditary Retinal Aplasia
Heredoretinopathia Congenitalis	Leber Abiotrophy
Leber Congenital Tapetoretinal Degeneration	Lebers Congenital Amaurosis
Optic Atrophy, Hereditary, Leber

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00987	ARL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	ARL3	MGD	MGI:1929699
Canis familiaris	ARL3	VGNC	VGNC:38111
Bos taurus	ARL3	VGNC	VGNC:26143
Felis catus	ARL3	VGNC	VGNC:68209
Rattus norvegicus	ARL3	RGD	RGD:69327

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ARL3 - ADP ribosylation factor like GTPase 3 Gene

关于 ARL3

功能概要

ARL3 基因产物(1)

ARL3 蛋白结构

ARL3 蛋白互作信息

关联疾病

直系同源

热门区域

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ARL3 - ADP ribosylation factor like GTPase 3 Gene

关于 ARL3

功能概要

ARL3 基因产物(1)

ARL3 蛋白结构

ARL3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z