2. Gene
  3. LSP1 - lymphocyte specific protein 1 Gene

LSP1 - lymphocyte specific protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：淋巴细胞特异性蛋白 1

种属: Homo sapiens

同用名: WP34; pp52

基因 ID: 4046 | 基因类型: protein coding

关于 LSP1

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:1,853,084-1,892,263 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele, 204 orthologues and 1 paralogue. Broad expression in spleen (RPKM 60.6), appendix (RPKM 43.3) and 19 other tissues.

功能概要

该基因编码细胞内 F-肌动蛋白结合蛋白。该蛋白在淋巴细胞、中性粒细胞、巨噬细胞和内皮细胞中表达，可调节中性粒细胞运动、与纤维蛋白原基质蛋白的粘附和跨内皮细胞迁移。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regulate neutrophil motility, adhesion to fibrinogen matrix proteins, and transendothelial migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

LSP1 基因产物(6)

mRNA Protein Name
NM_001013253.2 NP_001013271.1 lymphocyte-specific protein 1 isoform 2
NM_001013254.1 NP_001013272.1 lymphocyte-specific protein 1 isoform 2
NM_001013255.1 NP_001013273.1 lymphocyte-specific protein 1 isoform 2
NM_001242932.2 NP_001229861.1 lymphocyte-specific protein 1 isoform 3
NM_001289005.2 NP_001275934.1 lymphocyte-specific protein 1 isoform 2
NM_002339.3 NP_002330.1 lymphocyte-specific protein 1 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
35156780 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LSP1 蛋白结构

Caldesmon

Caldesmon: Caldesmon (191 - 300)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
蛋白主名 其他名称

lymphocyte-specific protein 1

47 kDa actin binding protein

LSP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LSP1 P33241 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LSP1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75916 LSP1 Protein, Human (HEK293, His) P33241-1 (M1-P339) ≥95%

LSP1 抗体

目录号 产品名 应用 反应物种
HY-P81344 LSP1 Antibody (YA1089) IHC-P Human

关联疾病

疾病名称 别名
Neutrophil Actin Dysfunction

NAD
Pyometritis
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07864 LSP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-11041 LSP1-2111 Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris LSP1 VGNC VGNC:42849
Rattus norvegicus LSP1 RGD RGD:1306133
Mus musculus LSP1 MGD MGI:96832
Bos taurus LSP1 VGNC VGNC:31063
Felis catus LSP1 VGNC VGNC:68096
Macaca mulatta LSP1 VGNC VGNC:101299
Others LSP1 NCBI
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