1. Gene
  2. LY6E - lymphocyte antigen 6 family member E Gene

LY6E - lymphocyte antigen 6 family member E Gene

中文名称:淋巴细胞抗原 6 家族成员 E

种属: Homo sapiens

同用名: RIGE; SCA2; RIG-E; SCA-2; TSA-1

基因 ID: 4061 | 基因类型: protein coding

关于 LY6E

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,018,529-143,022,409 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 148 orthologues and 2 paralogues. Ubiquitous expression in liver (RPKM 110.6), spleen (RPKM 88.2) and 24 other tissues.

功能概要

该基因属于人类 Ly6 基因家族,编码糖基磷脂酰肌醇 (GPI) 锚定细胞表面蛋白。该蛋白在 T 细胞生理学、肿瘤发生和免疫调节中起重要作用。该蛋白还参与调节冠状病毒、SARS-CoV、MERS-CoV 和 SARS-CoV-2 引起的病毒感染。[RefSeq 提供,2021 年 8 月]

This gene belongs to the human Ly6 gene family and encodes a glycosylphosphatidyl-inositol (GPI)-anchored cell surface protein. The protein plays an important role in T cell physiology, oncogenesis and immunological regulation. The protein is also involved in modulation of viral Infection by coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2021]

LY6E 基因产物(2)

mRNA Protein Name
NM_001127213.2 NP_001120685.1 lymphocyte antigen 6E precursor
NM_002346.3 NP_002337.1 lymphocyte antigen 6E precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of viral entry into host cell IDA
IDA: 通过直接分析推断
32641482 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

LY6E 蛋白结构

UPAR_LY6

UPAR_LY6: u-PAR/Ly-6 domain (23 - 99)

  • 0
  • 100
  • 131 a.a.
蛋白主名 其他名称

lymphocyte antigen 6E

ly-6E

LY6E 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LY6E Q16553 TMEM140 Homo sapiens Q9NV12
Validated Y2H
32296183
种属内
LY6E Q16553 MFSD6 Homo sapiens Q6ZSS7
Validated Y2H
32296183
种属内
LY6E Q16553 TMEM19 Homo sapiens Q96HH6
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LY6E 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71539 Lymphocyte antigen 6E/LY6E Protein, Human (His-SUMO) Q16553 (L21-S101) ≥95%

关联疾病

疾病名称 别名
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic

Hyperpigmentation With Or Without Hypopigmentation, Familial Progressive

FPHH

Melanosis Universalis Hereditaria

Muh

Familial Progressive Hyperpigmentation With Or Without Hypopigmentation

Hyperpigmentation, Familial Progressive, 2, Formerly

Fph2, Formerly

Hyperpigmentation With Or Without Hypopigmentation

Familial Progressive Hyper- And Hypopigmentation

Hyperpigmentation, Familial Progressive

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris LY6E VGNC VGNC:42873
Rattus norvegicus LY6E RGD RGD:1565342
Felis catus LY6E VGNC VGNC:81668
Bos taurus LY6E VGNC VGNC:31089
Mus musculus LY6E MGD MGI:106651
Others LY6E NCBI