2. Gene
  3. LY9 - lymphocyte antigen 9 Gene

LY9 - lymphocyte antigen 9 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：淋巴细胞抗原 9

种属: Homo sapiens

同用名: hly9; mLY9; CD229; SLAMF3

基因 ID: 4063 | 基因类型: protein coding

关于 LY9

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:160,796,174-160,828,255 (from NCBI)

This gene has 11 transcripts (splice variants), 132 orthologues and 9 paralogues. Biased expression in lymph node (RPKM 6.9), spleen (RPKM 5.2) and 11 other tissues.

功能概要

LY9 属于免疫调节受体的 SLAM 家族 (参见 SLAMF1；MIM 603492) 并与衔接分子 SAP (SH2D1A；MIM 300490) 相互作用 (Graham 等人，2006 [PubMed 16365421]) 。[OMIM 提供，2008 年 3 月]

LY9 belongs to the SLAM family of immunomodulatory receptors (see SLAMF1; MIM 603492) and interacts with the adaptor molecule SAP (SH2D1A; MIM 300490) (Graham et al., 2006 [PubMed 16365421]).[supplied by OMIM, Mar 2008]

LY9 基因产物(4)

mRNA Protein Name
NM_001033667.3 NP_001028839.1 T-lymphocyte surface antigen Ly-9 isoform b
NM_001261456.2 NP_001248385.1 T-lymphocyte surface antigen Ly-9 isoform c
NM_001261457.2 NP_001248386.1 T-lymphocyte surface antigen Ly-9 isoform d precursor
NM_002348.4 NP_002339.2 T-lymphocyte surface antigen Ly-9 isoform a precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T-helper 17 cell lineage commitment IDA
IDA: 通过直接分析推断
22184727 GOA
involved in positive regulation of interleukin-17 production IDA
IDA: 通过直接分析推断
22184727 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
22184727 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LY9 蛋白结构

Ig_3

Ig_3: Immunoglobulin domain (157 - 226)

Ig_3

Ig_3: Immunoglobulin domain (362 - 431)

  • 0
  • 200
  • 400
  • 600
  • 655 a.a.
蛋白主名 其他名称

T-lymphocyte surface antigen Ly-9

SLAM family member 3

重组 LY9 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72465 CD229/SLAMF3 Protein, Human (HEK293, His) Q9HBG7-1 (K48-K454) ≥95%
HY-P78487 CD229/SLAMF3 Protein, Human (HEK293, His-Avi) Q9HBG7 (K48-K454) ≥95%
HY-P700672 CD229/SLAMF3 Protein, Human (Biotinylated, HEK293, His-Avi) Q9HBG7-1 (K48-K454) ≥95%

关联疾病

疾病名称 别名
Multisystem Inflammatory Syndrome In Children

Mis-C

Multisystem Inflammatory Disorder In Children And Adolescents

Paediatric Inflammatory Multisystemic Syndrome

Mic
Lymphoproliferative Syndrome

Lymphoproliferative Disorder

Lymphoproliferative Disorders

Lymphoproliferative Disorders, Susceptibility To
Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]
Salpingo-Oophoritis

Tubo-Ovarian Inflammatory Disease

Salpingitis/Oophoritis

Suppurative Salpingo Oophoritis

Tubo-Ovarian Inflammation

Tubo-Ovarian Inflammatory Disorder

Purulent Salpingo Oophoritis

Septic Salpingo Oophoritis

Salpingo-Ovaritis

Inflammation Oviduct

Ruptured Salpingo Oophoritis

Pyosalpinx Rupture
Selective Immunoglobulin Deficiency Disease
Dysgammaglobulinemia
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Lymphoproliferative Syndrome, X-Linked, 1

Lymphomatoid Papulosis

Duncan Disease

Purtilo Syndrome

X-Linked Lymphoproliferative Syndrome

Xlp

X-Linked Lymphoproliferative Disease

XLP1

Lyp

Lymphoproliferative Disease, X-Linked

Xlpd

X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency

Ebv Infection, Severe, Susceptibility To

Ebvs

Immunodeficiency 5

Imd5

X-Linked Lymphoproliferative Syndrome 1

Epstein-Barr Virus Infection, Familial Fatal

Ebv Infection, Severe

Infectious Mononucleosis, Severe

Infectious Mononucleosis, Severe, Susceptibility To

Immunodeficiency, X-Linked Progressive Combined Variable

Epstein Barr Virus Infection, Familial Fatal

X-Linked Progressive Combined Variable Immunodeficiency 5

Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males

Familial Fatal Epstein-Barr Infection

Severe Susceptibility To Ebv Infection

Severe Susceptibility To Infectious Mononucleosis

Sap Deficiency

Sh2d1a/Slam-Associated Protein Deficiency

X-Linked Lymphoproliferative Syndrome Type 1

X-Linked Progressive Combined Variable Immunodeficiency

Lymphoproliferative Syndrome, X-Linked

Sap

X-Linked Lymphoproliferative Disorder
Smoldering Myeloma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07907 LY9 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus LY9 VGNC VGNC:68111
Canis familiaris LY9 VGNC VGNC:42877
Rattus norvegicus LY9 RGD RGD:1308341
Mus musculus LY9 MGD MGI:96885
Bos taurus LY9 VGNC VGNC:31094
Macaca fascicularis LY9 NCBI NCBI:102132723
Macaca mulatta LY9 NCBI NCBI:720255
Others LY9 NCBI
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