MXD1 - MAX dimerization protein 1 Gene

中文名称：MAX 二聚化蛋白 1

种属: Homo sapiens

同用名: MAD; MAD1; BHLHC58

关于 MXD1

功能概要

该基因编码基本螺旋-环-螺旋亮氨酸拉链转录因子的 MYC/MAX/MAD 网络的成员。 MYC/MAX/MAD 转录因子介导细胞增殖、分化和凋亡。编码的蛋白质通过竞争结合伴侣 MAX 和募集含有组蛋白脱乙酰酶的阻遏物复合物来拮抗 MYC 介导的靶基因转录激活。该基因的突变可能在急性白血病中发挥作用，编码的蛋白质是一种潜在的肿瘤抑制因子。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 2 月]

This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and Apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]