2. Gene
  3. MAZ - MYC associated zinc finger protein Gene

MAZ - MYC associated zinc finger protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MYC 相关锌指蛋白

种属: Homo sapiens

同用名: PUR1; ZF87; Pur-1; SAF-1; SAF-2; SAF-3; Zif87; ZNF801

基因 ID: 4150 | 基因类型: protein coding

关于 MAZ

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,806,124-29,811,164 (from NCBI)

This gene has 15 transcripts (splice variants), 248 orthologues and 36 paralogues. Ubiquitous expression in bone marrow (RPKM 38.3), colon (RPKM 34.1) and 25 other tissues.

功能概要

启用 DNA 结合转录因子活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调控区域序列特异性 DNA 结合活性。参与多个过程，包括基因表达的调节；调节信号转导；和 RNA 聚合酶 II 的转录。预测位于细胞质和细胞核中。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of gene expression; regulation of signal transduction; and transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MAZ 基因产物(4)

mRNA Protein Name
NM_001042539.3 NP_001036004.1 myc-associated zinc finger protein isoform 2
NM_001276275.2 NP_001263204.1 myc-associated zinc finger protein isoform 3
NM_001276276.2 NP_001263205.1 myc-associated zinc finger protein isoform 4
NM_002383.4 NP_002374.2 myc-associated zinc finger protein isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
25487955 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
1502157 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11527412 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of apoptotic signaling pathway IDA
IDA: 通过直接分析推断
25487955 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
26089202 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
25487955 GOA
involved in positive regulation of cell migration IDA
IDA: 通过直接分析推断
25487955 GOA
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
25487955 GOA
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
25487955 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
25487955 GOA
involved in termination of RNA polymerase II transcription IDA
IDA: 通过直接分析推断
1502157 GOA
involved in transcription initiation at RNA polymerase II promoter IDA
IDA: 通过直接分析推断
1502157 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MAZ 蛋白结构

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (190 - 212)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (293 - 318)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (337 - 360)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (366 - 385)

  • 0
  • 100
  • 200
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  • 400
  • 477 a.a.
蛋白主名 其他名称

myc-associated zinc finger protein

MAZI

MAZ 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MAZ P56270 DCC Homo sapiens P43146
Y2H
11527412
种属内
MAZ P56270 DCC Homo sapiens P43146
Pull Down
11527412
种属间
MAZ P56270 Dcc Mus musculus P70211
Y2H
11527412
种属内
MAZ P56270 APOD Homo sapiens P05090
Anti Tag CoIP
33961781
种属内
MAZ P56270 APOD Homo sapiens P05090
Anti Tag CoIP
28514442
种属间
MAZ P56270 dcc.L Crosspus laevis Q91562
Pull Down
11527412
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Amyloidosis

Amyloid Disease

Amyloid

Amyloid Degeneration

Amyloidosis Nos

Amyloid Deposition

Amyloid Infiltration

Idiopathic Amyloidosis

Hyaloid Degeneration

Lardaceous Degeneration
Von Hippel-Lindau Syndrome

Von Hippel-Lindau Disease

Vhl

Vhl Syndrome

VHLS

Von Hippel-Lindau Syndrome, Modifier Of

Hippel Lindau Syndrome

Angiomatosis Retinae

Cerebelloretinal Angiomatosis, Familial

Hippel-Lindau Disease

Familial Cerebelloretinal Angiomatosis

Lindau Disease

VHLD
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-116624 MAZ51 99.96% 否
HY-RS08178 MAZ Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MAZ VGNC VGNC:54041
Rattus norvegicus MAZ RGD RGD:1594632
Felis catus MAZ VGNC VGNC:107761
Bos taurus MAZ VGNC VGNC:106813
Mus musculus MAZ MGD MGI:1338823
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