2. Gene
  3. PIM3 - Pim-3 proto-oncogene, serine/threonine kinase Gene

PIM3 - Pim-3 proto-oncogene, serine/threonine kinase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Pim-3 原癌基因，丝氨酸/苏氨酸激酶

种属: Homo sapiens

同用名: pim-3

基因 ID: 415116 | 基因类型: protein coding

关于 PIM3

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:49,960,772-49,964,072 (from NCBI)

This gene has 2 transcripts (splice variants), 220 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 36.0), stomach (RPKM 21.6) and 25 other tissues.

功能概要

该基因编码的蛋白质属于 Ser/Thr 蛋白激酶家族和 Pim 亚家族。该基因在血液和上皮肿瘤中过度表达，并与 MYC 共表达相关。它在信号转导级联的调节中发挥作用，促进细胞增殖和存活，并在肿瘤发生中提供选择性优势。[RefSeq 提供，2012 年 6 月]

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and Pim subfamily. This gene is overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a selective advantage in tumorigenesis. [provided by RefSeq, Jun 2012]

PIM3 基因产物(1)

mRNA Protein Name
NM_001001852.4 NP_001001852.2 serine/threonine-protein kinase pim-3
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17270021 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
18593906 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
17270021 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
18593906 GOA
involved in regulation of mitotic cell cycle IMP
IMP: 通过突变表型推断
17270021 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PIM3 蛋白结构

Pkinase

Pkinase: Protein kinase domain (40 - 293)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase pim-3

pim-3 oncogene

serine/threonine kinase Pim-3

关联疾病

疾病名称 别名
Spinocerebellar Ataxia, X-Linked 5

SCAX5

X-Linked Spinocerebellar Ataxia 5

X-Linked Non Progressive Cerebellar Ataxia
Hepatic Flexure Cancer

Ca Hepatic Flexure - Colon

Malignant Neoplasm Of Hepatic Flexure

Malignant Tumor Of Hepatic Flexure

Carcinoma Of Hepatic Flexure

Malignant Neoplasm Of Hepatic Flexure Of Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-101870B Uzansertib phosphate Inhibitor 99.39% Phase 2
HY-101870 Uzansertib Inhibitor / Phase 2
HY-19322B PIM-447 dihydrochloride Inhibitor 99.94% Phase 1
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-16976 GDC-0339 Inhibitor 99.87% 否
HY-120758 SEL24-B489 Inhibitor 99.02% 否
HY-111552 PIM1-IN-1 Inhibitor 99.83% 否
HY-122665 HTH-01-091 Inhibitor 98.64% 否
HY-164460 AZD1897 Inhibitor 99.69% 否
HY-163442A PIM3-IN-1 hydrochloride Inhibitor / 否
HY-123983 HS56 Inhibitor / 否
HY-142696 CDK6/PIM1-IN-1 Inhibitor / 否
HY-101783 GNE-955 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PIM3 VGNC VGNC:107916
Mus musculus PIM3 MGD MGI:1355297
Bos taurus PIM3 VGNC VGNC:32901
Rattus norvegicus PIM3 RGD RGD:620462
Others PIM3 NCBI
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