MELTF - melanotransferrin Gene

中文名称：黑色素转铁蛋白

种属: Homo sapiens

同用名: MTf; MFI2; MTF1; CD228; MAP97

基因 ID: 4241 | 基因类型: protein coding

关于 MELTF

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:197,001,740-197,029,817 (from NCBI)

This gene has 9 transcripts (splice variants), 199 orthologues and 3 paralogues. Broad expression in salivary gland (RPKM 9.5), kidney (RPKM 5.4) and 16 other tissues.

功能概要

由该基因编码的蛋白质是一种在黑素瘤细胞上发现的细胞表面糖蛋白。该蛋白质与转铁蛋白超家族的成员具有序列相似性和铁结合特性。铁结合功能的重要性尚未确定。该基因与转铁蛋白超家族成员位于 3 号染色体的同一区域。可变剪接导致两种转录本变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]

MELTF 基因产物(2)

mRNA	Protein	Name
NM_005929.6	NP_005920.2	melanotransferrin isoform 1 preproprotein
NM_033316.4	NP_201573.1	melanotransferrin isoform 2 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables iron ion binding	IMP IMP: 通过突变表型推断	7556058	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	19815549	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in iron ion transport	IMP IMP: 通过突变表型推断	7556058	GOA
involved in negative regulation of substrate adhesion-dependent cell spreading	IDA IDA: 通过直接分析推断	16713448	GOA
involved in positive regulation of extracellular matrix disassembly	IDA IDA: 通过直接分析推断	16713448	GOA
involved in positive regulation of plasminogen activation	IDA IDA: 通过直接分析推断	16713448	GOA
NOT involved in regulation of cell growth	IMP IMP: 通过突变表型推断	7556058	GOA
NOT involved in regulation of cell population proliferation	IMP IMP: 通过突变表型推断	7556058	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell surface	IDA IDA: 通过直接分析推断	7556058	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	7556058	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MELTF 蛋白结构

Transferrin

0
200
400
600
738 a.a.

蛋白主名

其他名称

melanotransferrin

antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5

重组 MELTF 蛋白

目录号	产品名	蛋白编号	纯度
HY-P700671	Melanotransferrin/CD228 Protein, Human (HEK293, His)	P08582-1 (G20-C709)	≥95%

关联疾病

疾病名称

别名

Osteogenic Sarcoma

Osteosarcoma	OSRC
Osteosarcoma, Somatic	Neoplasms, Bone Tissue
Bone Tissue Neoplasm	Osteoid Sarcoma
Skeletal Sarcoma	Osteosarcoma Of Bone
Bone Sarcoma

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Melanotic Neuroectodermal Tumor

Melanotic Neuroectodermal Tumor Of Infancy	Neuroectodermal Tumor, Melanotic
Infantile Melanotic Neuroectodermal Neoplasm	Melanotic Neuroectodermal Tumour
Melanotic Neuroectodermal Tumour Of Infancy	Pigmented Neuroectodermal Tumour Of Infancy

Hemochromatosis, Type 1

Hemochromatosis	Hemochromatosis Type 1
Hereditary Hemochromatosis	Hh
HFE1	Hfe Hemochromatosis, Modifier Of
Symptomatic Form Of Classic Hemochromatosis	Symptomatic Form Of Hemochromatosis Type 1
Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis	Haemochromatosis
Iron Storage Disorder	Bronze Diabetes
Hereditary Haemochromatosis	Hlah
Hfe	Hemochromatosis, Hereditary
Diabetes Bronze	Classic Hemochromatosis
Hfe-Associated Hereditary Hemochromatosis	Hemochromatosis Classic
Bronzed Cirrhosis	Familial Hemochromatosis
Genetic Hemochromatosis	Hc
Pigmentary Cirrhosis	Primary Hemochromatosis
Troisier-Hanot-Chauffard Syndrome	Von Recklenhausen-Applebaum Disease
Hemochromatosis 1	Primary Hereditary Hemochromatosis
Bronze Cirrhosis

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08331	MELTF Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	MELTF	VGNC	VGNC:31383
Felis catus	MELTF	VGNC	VGNC:68243
Rattus norvegicus	MELTF	RGD	RGD:1308155
Mus musculus	MELTF	MGD	MGI:1353421
Canis familiaris	MELTF	VGNC	VGNC:43155
Macaca mulatta	MELTF	VGNC	VGNC:74711
Others	MELTF	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MELTF - melanotransferrin Gene

关于 MELTF

功能概要

MELTF 基因产物(2)

MELTF 蛋白结构

重组 MELTF 蛋白

关联疾病

直系同源

热门区域

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MELTF - melanotransferrin Gene

关于 MELTF

功能概要

MELTF 基因产物(2)

MELTF 蛋白结构

重组 MELTF 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z