MGAT5 - alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Gene

中文名称：α-1,6-甘露糖糖蛋白 6-β-N-乙酰氨基葡萄糖转移酶

种属: Homo sapiens

同用名: GNT-V; GNT-VA; MGAT5A; glcNAc-T V

基因 ID: 4249 | 基因类型: protein coding

关于 MGAT5

Cytogenetic location: 2q21.2-q21.3 Genomic coordinates (GRCh38): 2:134,119,935-134,454,621 (from NCBI)

This gene has 5 transcripts (splice variants), 130 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 14.6), lymph node (RPKM 12.4) and 24 other tissues.

功能概要

该基因编码的蛋白质属于糖基转移酶家族。它催化将 β-1,6-N-乙酰葡糖胺添加到新合成糖蛋白上存在的双触角 N-连接寡糖的 α-连接甘露糖。它是参与调节糖蛋白寡糖生物合成的最重要的酶之一。细胞表面糖蛋白上寡糖的改变会导致细胞粘附或迁移行为发生显着变化。这种酶活性的增加与侵袭性恶性肿瘤的进展有关。[RefSeq 提供，2011 年 10 月]

The protein encoded by this gene belongs to the Glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important Enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this Enzyme has been correlated with the progression of invasive malignancies. [provided by RefSeq, Oct 2011]

MGAT5 基因产物(2)

mRNA	Protein	Name
NM_001371457.1	NP_001358386.1	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
NM_002410.5	NP_002401.1	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	IDA IDA: 通过直接分析推断	10395745	GOA
enables manganese ion binding	IDA IDA: 通过直接分析推断	10395745	GOA
enables protein phosphatase inhibitor activity	IDA IDA: 通过直接分析推断	24846175	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of cell migration	IDA IDA: 通过直接分析推断	24846175	GOA
involved in positive regulation of receptor signaling pathway via STAT	IDA IDA: 通过直接分析推断	24846175	GOA
involved in protein N-linked glycosylation	IDA IDA: 通过直接分析推断	24846175	GOA
involved in protein N-linked glycosylation via asparagine	IDA IDA: 通过直接分析推断	10395745	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in membrane	IDA IDA: 通过直接分析推断	10395745	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MGAT5 蛋白结构

DUF4525

Glyco_transf_18

0
200
400
600
741 a.a.

蛋白主名

其他名称

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

N-acetylglucosaminyl-transferase V

重组 MGAT5 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75927	MGAT5 Protein, Human (HEK293, His)	Q09328 (L189-L741)	≥95%

关联疾病

疾病名称

别名

Congenital Disorder Of Glycosylation, Type Iia

CDG2A	Congenital Disorder Of Glycosylation Type Iia
Cdg Iia	Cdgiia
Congenital Disorder Of Glycosylation Type 2a	Alkuraya Syndrome
Mental Retardation, Growth Retardation, Prominent Columella, And Open Mouth	Carbohydrate-Deficient Glycoprotein Syndrome, Type Ii
Mgat2-Cdg	Cdg-Iia
Carbohydrate-Deficient Glycoprotein Syndrome, Type Ii, Formerly	Cdgs2, Formerly
Cdgs2	Cdg Syndrome Type Iia
Carbohydrate Deficient Glycoprotein Syndrome Type Iia	N-Acetylglucosaminyltransferase 2 Deficiency
Congenital Disorder Of Glycosylation 2a	Carbohydrate-Deficient Glycoprotein Syndrome Type Ii
Cdgs Type Ii	Carbohydrate-Deficient Glycoprotein Syndrome Type 2
Glycosylation, Congenital Disorder Of, Type Iia

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Walker-Warburg Syndrome

Hard Syndrome	Walker-Warburg Congenital Muscular Dystrophy
Cerebroocular Dysplasia-Muscular Dystrophy Syndrome	Cod-Md Syndrome
Chemke Syndrome	Hydrocephalus, Agyria And Retinal Dysplasia
Cerebroocular Dysgenesis	Cerebroocular Dysplasia Muscular Dystrophy Syndrome
Hard +/- E Syndrome	Pagon Syndrome
Warburg Syndrome	Hydrocephalus, Agyria, And Retinal Dysplasia
Mddga	Muscular Dystrophy-Dystroglycanopathy , Type A
Muscular Dystrophy-Dystroglycanopathy [With Brain And Eye Anomalies], Type A	Hydrocephalus-Agyria-Retinal Dysplasia Syndrome
Wws	Dystrophy, Muscular, Dystroglycanopathy, Type A

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08407	MGAT5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS08408	MGAT5B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	MGAT5	VGNC	VGNC:74716
Mus musculus	MGAT5	MGD	MGI:894701
Rattus norvegicus	MGAT5	RGD	RGD:620100
Bos taurus	MGAT5	VGNC	VGNC:54620
Felis catus	MGAT5	VGNC	VGNC:68249
Canis familiaris	MGAT5	VGNC	VGNC:54809
Others	MGAT5	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MGAT5 - alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Gene

关于 MGAT5

功能概要

MGAT5 基因产物(2)

MGAT5 蛋白结构

重组 MGAT5 蛋白

关联疾病

直系同源

热门区域

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MGAT5 - alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Gene

关于 MGAT5

功能概要

MGAT5 基因产物(2)

MGAT5 蛋白结构

重组 MGAT5 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z