MICB - MHC class I polypeptide-related sequence B Gene

中文名称：MHC I 类多肽相关序列 B

种属: Homo sapiens

同用名: PERB11.2

基因 ID: 4277 | 基因类型: protein coding

关于 MICB

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,494,918-31,511,124 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 405 orthologues and 22 paralogues. Broad expression in lymph node (RPKM 4.7), bone marrow (RPKM 4.2) and 20 other tissues.

功能概要

该基因编码一种高度糖基化的蛋白质，它是 NKG2D II 型受体的配体。配体的结合会激活自然杀伤 (NK) 细胞、CD8 字母 T 细胞和表达受体的γδ T 细胞的细胞溶解反应。这种蛋白质是应激诱导的，类似于 MHC I 类分子；但是，它不与 β-2-微球蛋白结合或结合肽。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 1 月]

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind Peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

MICB 基因产物(3)

mRNA	Protein	Name
NM_001289160.2	NP_001276089.1	MHC class I polypeptide-related sequence B isoform 2
NM_001289161.2	NP_001276090.1	MHC class I polypeptide-related sequence B isoform 3 precursor
NM_005931.5	NP_005922.2	MHC class I polypeptide-related sequence B isoform 1 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables natural killer cell lectin-like receptor binding	IDA IDA: 通过直接分析推断	11491531	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in gamma-delta T cell activation	IDA IDA: 通过直接分析推断	9497295	GOA
involved in immune response-activating cell surface receptor signaling pathway	IDA IDA: 通过直接分析推断	11491531	GOA
involved in negative regulation of defense response to virus by host	IDA IDA: 通过直接分析推断	11239445	GOA
involved in response to heat	IDA IDA: 通过直接分析推断	9497295	GOA
involved in response to oxidative stress	IDA IDA: 通过直接分析推断	11287116	GOA
involved in response to retinoic acid	IDA IDA: 通过直接分析推断	12569559	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MICB 蛋白结构

MHC_I

C1-set

0
100
200
300
383 a.a.

蛋白主名

其他名称

MHC class I polypeptide-related sequence B

MHC class I antigen-related protein B

重组 MICB 蛋白

目录号	产品名	蛋白编号	纯度
HY-P73293	MICB Protein, Human (HEK293, His-Fc)	Q29980-1/NP_005922.2 (A23-G298)	≥95%
HY-P73294	MICB Protein, Human (HEK293, His)	NP_005922.2 (A23-G298)	≥95%
HY-P78174	MICB Protein, Human (Biotinylated, HEK293, His-Avi)	Q29980-1 (A23-G298)	≥95%
HY-P78491	MICB Protein, Human (HEK293, His-Avi)	Q29980-1 (A23-G298)	≥95%
HY-P701023	MICB Protein, Human (HEK293, hFc)	Q29980-1 (A23-G298)	≥95%

MICB 抗体

目录号	产品名	应用	反应物种
HY-P81721	MICB Antibody (YA1466)	FC, ELISA	Human

关联疾病

疾病名称

别名

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Asymptomatic Dengue

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-101780A	Tinostamustine hydrochloride	Inhibitor	/	否
HY-RS08430	MICB Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990467	Anti-MICB Antibody	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	MICB	MGD	MGI:2179989
Rattus norvegicus	MICB	RGD	RGD:1564508

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