2. Gene
  3. MMP17 - matrix metallopeptidase 17 Gene

MMP17 - matrix metallopeptidase 17 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：基质金属肽酶 17

种属: Homo sapiens

同用名: MMP-17; MT4MMP; MTMMP4; MT4-MMP

基因 ID: 4326 | 基因类型: protein coding

关于 MMP17

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:131,828,393-131,851,771 (from NCBI)

This gene has 9 transcripts (splice variants), 257 orthologues and 23 paralogues. Broad expression in brain (RPKM 3.8), skin (RPKM 1.6) and 16 other tissues.

功能概要

该基因编码肽酶 M10 家族和基质金属蛋白酶 (MMP) 膜型亚家族的成员。该家族中的蛋白质参与正常生理过程 (如胚胎发育、繁殖和组织重塑) 以及疾病过程 (如关节炎和转移) 中细胞外基质的分解。该亚家族的成员包含一个跨膜结构域，表明这些蛋白质在细胞表面表达而不是分泌。编码的前原蛋白经过蛋白水解处理以产生成熟的蛋白酶。这种蛋白质在膜型基质金属蛋白酶中是独一无二的，因为它通过糖基磷脂酰肌醇 (GPI) 锚固定在细胞膜上。已在骨关节炎和多种人类癌症中观察到编码蛋白的表达升高。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of the peptidase M10 family and membrane-type subfamily of Matrix Metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature Protease. This protein is unique among the membrane-type Matrix Metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers. [provided by RefSeq, Jan 2016]

MMP17 基因产物(13)

mRNA Protein Name
XM_047428862.1 XP_047284818.1 matrix metalloproteinase-17 isoform X6
XR_001748705.2
XM_047428860.1 XP_047284816.1 matrix metalloproteinase-17 isoform X4
XM_047428861.1 XP_047284817.1 matrix metalloproteinase-17 isoform X5
XR_944552.3
NM_016155.7 NP_057239.4 matrix metalloproteinase-17 isoform 1 precursor
XM_047428859.1 XP_047284815.1 matrix metalloproteinase-17 isoform X3
XM_011538355.4 XP_011536657.1 matrix metalloproteinase-17 isoform X1
XM_011538357.3 XP_011536659.1 matrix metalloproteinase-17 isoform X1
NM_001411000.1 NP_001397929.1 matrix metalloproteinase-17 isoform 2
XR_944551.3
XM_017019307.2 XP_016874796.1 matrix metalloproteinase-17 isoform X2
XM_011538356.4 XP_011536658.1 matrix metalloproteinase-17 isoform X1

MMP17 蛋白结构

PG_binding_1

PG_binding_1: Putative peptidoglycan binding domain (46 - 105)

Peptidase_M10

Peptidase_M10: Matrixin (132 - 295)

Hemopexin

Hemopexin: Hemopexin (336 - 379)

Hemopexin

Hemopexin: Hemopexin (385 - 428)

Hemopexin

Hemopexin: Hemopexin (431 - 477)

Hemopexin

Hemopexin: Hemopexin (480 - 521)

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  • 603 a.a.
蛋白主名 其他名称

matrix metalloproteinase-17

MT-MMP 4

matrix metallopeptidase 17 (membrane-inserted)

matrix metalloproteinase 17 (membrane-inserted)

membrane-type matrix metalloproteinase 4

membrane-type-4 matrix metalloproteinase

关联疾病

疾病名称 别名
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Winchester Syndrome

WNCHRS

Winchester Disease

Winchester-Grossman Syndrome
Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm

Annuloaortic Ectasia

Familial Thoracic Aortic Aneurysm And Aortic Dissection

Familial Aortic Dissection

Familial Taad

Congenital Aneurysm Of Ascending Aorta

Familial Aortic Aneurysm

Familial Thoracic Aortic Aneurysm

Familial Thoracic Aortic Aneurysm And Dissection

Aortic Aneurysm, Thoracic

AAT1

Faa1

Aortic Dissection, Familial

Aortic Aneurysm, Familial Thoracic

Aneurysm, Thoracic Aortic

Faa

Ftaad

Taa

Taad

Cystic Medial Necrosis Of Aorta

Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection

Aortic Aneurysm Thoracic

Familial Aortic Aneurysms

Aneurysm, Aortic, Thoracic, Familial, Type 1

Aneurysm Of Thoracic Aorta

Intrathoracic Aneurysm

Thoracic Aorta Aneurysm

Thoracic Aortic Aneurysm Without Rupture

Thoracic Aneurysm

Thorax Arterial Aneurysm

Thoracic Artery Aneurysm

Thoracic Arterial Aneurysm

Thorax Aneurysm

Thorax Aortic Aneurysm

Dissection Of Thoracic Aorta
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-110397 KP-457 Inhibitor 99.18% 否
HY-107428 PD-166793 Inhibitor 99.45% 否
HY-110397G KP-457 (GMP) Inhibitor / 否
HY-RS08533 MMP17 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08534 Mmp17 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08535 Mmp17 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MMP17 VGNC VGNC:59062
Mus musculus MMP17 MGD MGI:1346076
Bos taurus MMP17 VGNC VGNC:31522
Rattus norvegicus MMP17 RGD RGD:1311541
Macaca mulatta MMP17 VGNC VGNC:74895
Felis catus MMP17 VGNC VGNC:68285
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