2. Gene
  3. CD200 - CD200 molecule Gene

CD200 - CD200 molecule Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：CD200 分子

种属: Homo sapiens

同用名: MRC; MOX1; MOX2; OX-2

基因 ID: 4345 | 基因类型: protein coding

关于 CD200

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:112,332,573-112,362,812 (from NCBI)

This gene has 8 transcripts (splice variants), 512 orthologues and 14 paralogues. Broad expression in brain (RPKM 5.4), placenta (RPKM 3.5) and 22 other tissues.

功能概要

该基因编码一种 I 型膜糖蛋白，包含两个细胞外免疫球蛋白结构域，一个跨膜结构域和一个细胞质结构域。该基因由多种细胞类型表达，包括 B 细胞、T 细胞亚群、胸腺细胞、内皮细胞和神经元。编码的蛋白质在免疫抑制和抗肿瘤活性调节中起重要作用。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2016 年 1 月]

This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

CD200 基因产物(10)

mRNA Protein Name
NM_001004196.4 NP_001004196.2 OX-2 membrane glycoprotein isoform b
NM_001318826.2 NP_001305755.1 OX-2 membrane glycoprotein isoform c
NM_001318828.2 NP_001305757.1 OX-2 membrane glycoprotein isoform d
NM_001318830.2 NP_001305759.1 OX-2 membrane glycoprotein isoform c
NM_001365851.2 NP_001352780.1 OX-2 membrane glycoprotein isoform e precursor
NM_001365852.1 NP_001352781.1 OX-2 membrane glycoprotein isoform f precursor
NM_001365853.1 NP_001352782.1 OX-2 membrane glycoprotein isoform f precursor
NM_001365854.1 NP_001352783.1 OX-2 membrane glycoprotein isoform f precursor
NM_001365855.1 NP_001352784.1 OX-2 membrane glycoprotein isoform c
NM_005944.7 NP_005935.4 OX-2 membrane glycoprotein isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21982860 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in heterotypic cell-cell adhesion IGI
IGI: 通过遗传相互作用推断
11260322 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
26670206 GOA
involved in negative regulation of matrix metallopeptidase secretion IDA
IDA: 通过直接分析推断
29101312 GOA
involved in positive regulation of CREB transcription factor activity IDA
IDA: 通过直接分析推断
26670206 GOA
involved in positive regulation of arginase activity IGI
IGI: 通过遗传相互作用推断
26670206 GOA
involved in positive regulation of protein-glutamine gamma-glutamyltransferase activity IGI
IGI: 通过遗传相互作用推断
26670206 GOA
involved in positive regulation of transforming growth factor beta production IGI
IGI: 通过遗传相互作用推断
26670206 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
19151626 GOA
located in cell body IDA
IDA: 通过直接分析推断
19151626 GOA
located in cell surface IDA
IDA: 通过直接分析推断
11260322 GOA
located in neuronal cell body IDA
IDA: 通过直接分析推断
19151626 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CD200 蛋白结构

ig

ig: Immunoglobulin domain (72 - 146)

ig

ig: Immunoglobulin domain (179 - 241)

  • 0
  • 100
  • 200
  • 294 a.a.
蛋白主名 其他名称

OX-2 membrane glycoprotein

CD200 antigen

CD200 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CD200 P41217 CD200R1 Homo sapiens Q8TD46
Protein Array
21982860
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CD200 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70476 CD200 Protein, Human (HEK293, His) P41217-1 (Q31-G232) ≥95%
HY-P72887 CD200 Protein, Human (HEK293, Fc) P41217-1 (Q31-G232) ≥95%
HY-P75432 CD200 Protein, Human (HEK293, Fc-Avi) P41217-1/NP_005935.4 (Q31-G232) ≥95%

CD200 抗体

目录号 产品名 应用 反应物种
HY-P81630 CD200 Antibody (YA1375) FC, ELISA Human

关联疾病

疾病名称 别名
Inflamed Seborrheic Keratosis
Hairy Cell Leukemia

Hcl-V

Hairy Cell Leukemia Variant

Hairy Cell Leukaemia Variant

Hcl

Leukemic Reticuloendotheliosis

Leukemic Reticuloendotheliosis Variant

Prolymphocytic Variant Of Hcl

Prolymphocytic Variant Of Hairy Cell Leukemia

Leukemia Hairy Cell

Leukemia, Hairy Cell

Leukaemic Reticuloendotheliosis

Lre - [Leukemic Reticuloendotheliosis]

Hairy-Cell Leukaemia, Nos

Hcl - [Hairy Cell Leukaemia]

Hairy-Cell Leukaemia Without Mention Of Remission
B-Cell Prolymphocytic Leukemia

B Cell Prolymphocytic Leukemia

Prolymphocytic Leukemia, B-Cell Type

B-Pll

Doid:0081041

Leukemia, Prolymphocytic, B-Cell

Pll- [Prolymphocytic Leukaemia]

Prolymphocytic Leukaemia

Prolymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission
Spiradenoma

Eccrine Spiradenoma

Benign Eccrine Spiradenoma

Eccrine Spiradenoma Of Skin

Es

Eccrine Spiradenoma, Benign
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Cll/Sll

B-Cell Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Icdo:9823/3

Chronic Lymphocytic Leukaemia Of B-Cell Type Without Mention Of Remission

Small Cell B-Cell Lymphoma
Androgenic Alopecia

Androgenetic Alopecia

Alopecia Androgenetica, Male Pattern Baldness
Methemoglobinemia And Ambiguous Genitalia

METAG

Methemoglobinemia Type Iv

Isolated 17,20-Lyase Deficiency, Pure

Methemoglobinemia Due To Deficiency Of Cytochrome B5

Methemoglobinemia Type 4

Methemoglobinemia Type Iv, Formerly

Methemoglobinemia Due To Deficiency Of Cytochrome B5, Formerly

Pure Isolated 17,20-Lyase Deficiency

Methemoglobinemia, Type Iv
Rocky Mountain Spotted Fever

Brazillian Spotted

Choix

Exanthematic Typhus Of Sao Paulo

Fiebre Maculosa

Fiebre Manchada

Sao Paulo Typhus

So Paulo Fever

Tick Typhus

Tobia Fever

Rmsf

Typhus, Tick
Atrial Septal Defect 8

ASD8

Atrial Heart Septal Defect 8

Septal Defect, Atrial, Type 8
Flying Phobia

Aerophobia
Combined Oxidative Phosphorylation Deficiency 33

COXPD33
Mantle Cell Lymphoma

Lymphoma, Mantle Cell

Lcm

Mcl

Mantle Zone Lymphoma

Lymphoma Mantle-Cell

Lymphoma, Mantle-Cell

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

Diffuse Small Cleaved-Cell Lymphoma

Diffuse Small Cleaved Cell Malignant Lymphoma

Small Cleaved Cell Non-Hodgkin Lymphoma

Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

Malignant Lymphomatous Polyposis

Malignant Small Cell, Noncleaved, Diffuse Lymphoma

Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

Cleaved Cell Lymphoma

Small Cell Mantle Cell Lymphoma

Small Cleaved Cell Malignant Lymphoma
Aniridia 1

Aniridia

Congenital Aniridia

AN1

An

Cataract With Late-Onset Corneal Dystrophy

Aplasia Of Iris

Absent Iris

Irideremia

Aniridia Ii, Formerly

An2, Formerly

An2

Aniridia Type Ii

Aniridia, Type 1

An-1

Absence Of Iris

Agenesis Of Iris

Congenital Absence Of Iris

Hereditary Aniridia

Sporadic Aniridia
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02205 CD200 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02206 CD200R1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02207 CD200R1L Human Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990479 Anti-OX2R/CD200R1 Antibody Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CD200 VGNC VGNC:38938
Felis catus CD200 VGNC VGNC:102623
Rattus norvegicus CD200 RGD RGD:3104
Bos taurus CD200 VGNC VGNC:27010
Macaca mulatta CD200 VGNC VGNC:70931
Mus musculus CD200 MGD MGI:1196990
Macaca fascicularis CD200 NCBI NCBI:102146004
Others CD200 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z