MPST - mercaptopyruvate sulfurtransferase Gene

中文名称：巯基丙酮酸硫转移酶

种属: Homo sapiens

同用名: MST; TST2; TUM1

关于 MPST

功能概要

这种由该基因编码的蛋白质催化硫离子从 3-巯基丙酮酸转移到氰化物或其他硫醇化合物。它可能参与半胱氨酸降解和氰化物解毒。文献中混淆了这种似乎存在于细胞质中的蛋白质 (巯基丙酮酸硫转移酶，MPST) 和线粒体蛋白质硫代硫酸盐硫转移酶 (硫代硫酸盐酶，TST，GeneID：7263) 。 MPST 活性的缺陷与一种罕见的遗传性疾病有关，称为巯基乳酸-半胱氨酸二硫尿症 (MCDU) 。已经为该基因鉴定了编码相同或不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This protein encoded by this gene catalyzes the transfer of a sulfur ion from 3-mercaptopyruvate to cyanide or Other thiol compounds. It may be involved in cysteine degradation and cyanide detoxification. There is confusion in literature between this protein (mercaptopyruvate sulfurtransferase, MPST), which appears to be cytoplasmic, and thiosulfate sulfurtransferase (rhodanese, TST, GeneID:7263), which is a mitochondrial protein. Deficiency in MPST activity has been implicated in a rare inheritable disorder known as mercaptolactate-cysteine disulfiduria (MCDU). Alternatively spliced transcript variants encoding same or different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]