MRC1 - mannose receptor C-type 1 Gene

中文名称：甘露糖受体 C 型 1

种属: Homo sapiens

同用名: MMR; hMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1

基因 ID: 4360 | 基因类型: protein coding

关于 MRC1

Cytogenetic location: 10p12.33 Genomic coordinates (GRCh38): 10:17,809,348-17,911,164 (from NCBI)

This gene has 1 transcript (splice variant), 423 orthologues and 4 paralogues. Broad expression in lung (RPKM 50.7), spleen (RPKM 28.0) and 19 other tissues.

功能概要

糖蛋白上复杂碳水化合物结构的识别是多种生物过程的重要组成部分，包括细胞间识别、血清糖蛋白更新和病原体中和。由该基因编码的蛋白质是一种 I 型膜受体，可介导巨噬细胞对糖蛋白的内吞作用。该蛋白质已被证明可以结合潜在致病病毒、细菌和真菌表面的高甘露糖结构，因此它们可以被吞噬作用中和。[RefSeq 提供，2015 年 9 月]

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]

MRC1 基因产物(1)

mRNA	Protein	Name
NM_002438.4	NP_002429.1	macrophage mannose receptor 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cargo receptor activity	IDA IDA: 通过直接分析推断	20035344	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11222859	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in receptor-mediated endocytosis	IDA IDA: 通过直接分析推断	20035344	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endosome membrane	IDA IDA: 通过直接分析推断	20035344	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	20035344	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MRC1 蛋白结构

Ricin_B_lectin

fn2

Lectin_C

0
300
600
900
1200
1456 a.a.

蛋白主名

其他名称

macrophage mannose receptor 1

C-type lectin domain family 13 member D

重组 MRC1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P78736	CD206/MMR Protein, Human (HEK293, His)	P22897-1 (L19-A1389)	≥95%

关联疾病

疾病名称

别名

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

Gaucher'S Disease

Gaucher Disease	Kerasin Thesaurismosis
Glucocerebrosidase Deficiency	Glucosylceramidase Deficiency
Cerebroside Lipidosis Syndrome	Acid Beta-Glucosidase Deficiency
Glucosylceramide Beta-Glucosidase Deficiency	Acute Cerebral Gaucher Disease
Gaucher Splenomegaly	Glucocerebrosidosis
Glucosyl Cerebroside Lipidosis	Kerasin Lipoidosis
Lipoid Histiocytosis	Glocucerebrosidase Deficiency
Sphingolipidosis 1	Gaucher Syndrome
Gauchers Disease	Gd
Glucosylceramide Lipidosis	Kerasin Histiocytosis
Gaucher Disease, Type 1	Gaucher Disease, Type 2

Hepatitis B

Chronic Hepatitis B	Hepatitis B Infection
Serum Hepatitis	HBV
Hepatitis B Chronic	Hbv, Susceptibility To
Hepatitis B, Chronic	Chronic Hepatitis B Without Delta Agent
Chronic Hbv - [Hepatitis B Virus] Infection	Hepatitis B Nos
Chronic Type B Viral Hepatitis	Hep B Nos

Hepatitis

Chronic Hepatitis	Chronic Persistent Hepatitis
Acute Hepatitis	Hepatitis, Chronic
Acute And Subacute Liver Necrosis	Acute/Subac. Necrosis Of Liver
Animal Hepatitis	Hepatitis Chronic
Hepatitis A	Hepatitis, Animal
Hepatitis Due To Toxoplasmosis	Hepatitis In Toxoplasmosis
Toxoplasmal Hepatitis	Chronic Hepatitis, Unspecified
Chronic Active Hepatitis Nec	Other Specified Chronic Hepatitis
Chronic Persistent Hepatitis Nec	Chronic Lobular Hepatitis Nec

Gastroparesis

Gastroparesis Syndrome	Delayed Gastric Emptying
Gastric Atonia	Gastroparalysis

Mycobacterium Tuberculosis 1

Tuberculosis	Tuberculoma
Tuberculosis, Susceptibility To	Mycobacterium Tuberculosis, Susceptibility To, 1
Mtbs1	TB

Tenosynovial Giant Cell Tumor

Fibrous Histiocytoma Of Tendon Sheath	Giant Cell Tumor Of Tendon Sheath
Giant Cell Tumor Of Tenosynovium	Giant Cell Tumour Of Tendon Sheath
Giant Cell Tumour Of Tenosynovium	Tenosynovial Giant Cell Tumour
Diffuse-Type Gct	Diffuse-Type Giant Cell Tumor
Pigmented Villonodular Synovitis	Tgct
Tsgct

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis	Ipf
Fibrocystic Pulmonary Dysplasia	Pulmonary Fibrosis, Idiopathic
Pulmonary Fibrosis, Idiopathic, Susceptibility To	Cryptogenic Fibrosing Alveolitis
ILD2	Idiopathic Pulmonary Fibrosis, Familial
Fibrosing Alveolitis, Cryptogenic	Uip
Fibrosing Alveolitis	Interstitial Pneumonitis, Usual
Familial Idiopathic Pulmonary Fibrosis	Idiopathic Fibrosing Alveolitis, Chronic Form
Usual Interstitial Pneumonia	Fibrosing Alveolitis Cryptogenic
Hamman-Rich Disease	Idiopathic Pulmonary Fibrosis Familial
Interstitial Pneumonitis Usual	Fibrosis Idiopathic Pulmonary
Fibrosis, Pulmonary, Idiopathic	Hamman-Rich Syndrome
Chronic Idiopathic Pulmonary Fibrosis	Acute Interstitial Pneumonia
Interstitial Pulmonary Fibrosis	Ipf - [Idiopathic Pulmonary Fibrosis]
Idiopathic Lung Fibrosis	Fibrosing Lung Disease
Pulmonary Fibrosis Nos	Fibrosing Pneumonitis

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-107509	LY2389575 hydrochloride	Modulator	99.93%	否
HY-RS08641	MRC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	MRC1	VGNC	VGNC:31598
Felis catus	MRC1	VGNC	VGNC:68315
Rattus norvegicus	MRC1	RGD	RGD:1309353
Mus musculus	MRC1	MGD	MGI:97142
Macaca mulatta	MRC1	VGNC	VGNC:74925
Canis familiaris	MRC1	VGNC	VGNC:43359
Others	MRC1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MRC1 - mannose receptor C-type 1 Gene

关于 MRC1

功能概要

MRC1 基因产物(1)

MRC1 蛋白结构

重组 MRC1 蛋白

关联疾病

直系同源

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MRC1 - mannose receptor C-type 1 Gene

关于 MRC1

功能概要

MRC1 基因产物(1)

MRC1 蛋白结构

重组 MRC1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z