MT1A - metallothionein 1A Gene

中文名称：金属硫蛋白 1A

种属: Homo sapiens

同用名: MT1; MTC; MT1S; MT-1A; MT-IA

关于 MT1A

功能概要

该基因是金属硫蛋白基因家族的成员。该基因家族编码的蛋白质分子量低，富含半胱氨酸，不含芳香族残基，可结合二价重金属离子。保守的半胱氨酸残基使用硫醇键配位金属离子。这些蛋白质充当抗氧化剂，防止羟基自由基，对细胞内金属的稳态控制很重要，并在重金属解毒中发挥作用。小鼠中两个金属硫蛋白基因的破坏导致对重金属、氧化应激、免疫反应、致癌物和肥胖症的保护缺陷。[RefSeq 提供，2017 年 9 月]

This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. The conserved cysteine residues co-ordinate metal ions using mercaptide linkages. These proteins act as anti-oxidants, protect against hydroxyl free radicals, are important in homeostatic control of metal in the cell, and play a role in detoxification of heavy metals. Disruption of two metallothionein genes in mouse resulted in defects in protection against heavy metals, oxidative stress, immune reactions, carcinogens, and displayed obesity. [provided by RefSeq, Sep 2017]