1. Gene
  2. MUC7 - mucin 7, secreted Gene

MUC7 - mucin 7, secreted Gene

中文名称:粘蛋白 7,分泌型

种属: Homo sapiens

同用名: MG2

基因 ID: 4589 | 基因类型: protein coding

关于 MUC7

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,430,492-70,482,997 (from NCBI)

This gene has 7 transcripts (splice variants), 25 orthologues and is associated with 1 phenotype. Restricted expression toward salivary gland (RPKM 5748.3).

功能概要

该基因编码一种小的唾液粘蛋白,它被认为在促进口腔细菌清除和帮助咀嚼、说话和吞咽方面发挥作用。这种糖蛋白的中心区域包含串联重复序列,每个重复序列由 23 个氨基酸组成。这种抗菌蛋白具有抗菌和抗真菌活性。最常见的等位基因包含 6 个重复,部分等位基因可能与哮喘易感性有关。已经发现该基因具有不同 5' UTR 但编码相同蛋白质的选择性剪接转录变体。[RefSeq 提供,2014 年 10 月]

This gene encodes a small salivary Mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 Amino acids. This antimicrobial protein has Antibacterial and Antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Oct 2014]

MUC7 基因产物(3)

mRNA Protein Name
NM_001145006.2 NP_001138478.1 mucin-7 precursor
NM_001145007.2 NP_001138479.1 mucin-7 precursor
NM_152291.3 NP_689504.2 mucin-7 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16203048 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: 通过直接分析推断
12543672 GOA
involved in killing of cells of another organism IDA
IDA: 通过直接分析推断
12543672 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

mucin-7

MUC-7

MUC7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MUC7 Q8TAX7 AMY1A Homo sapiens P0DTE7 16203048
种属内
MUC7 Q8TAX7 AMY1A Homo sapiens P0DTE7
Y2H
16203048
种属内
MUC7 Q8TAX7 STATH Homo sapiens P02808
Y2H
16203048
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Chronic Ethmoiditis

Chronic Ethmoidal Sinusitis

Chronic Ethmoid Sinusitis

Ethmoidal Sinusitis - Chronic

Burning Mouth Syndrome

Orodynia

Stomatodynia

Stomatopyrosis

Bms

Burning Mouth Disorder

Oral Dysesthesia

Sore Mouth Syndrome

Bms - [Burning Mouth Syndrome]

Dental Caries

Dental Caries Extending Into Pulp

Dental Caries Of Smooth Surface

Dental Caries Pit And Fissure

Smooth Surface Dental Caries

Dental Decay

Carious Teeth

Dental Cavity

Saprodontia

Teeth Decayed

Tooth Caries

Tooth Decay

Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder

Combat Disorder

Combat Disorders

Combat Neurosis

Sialolithiasis

Sialolith

Stone Of Salivary Gland Or Duct

Salivary Gland Calculi

Salivary Gland Stone

Calculus Of Salivary Gland Or Duct

Calculus Of Salivary Gland

Salivary Calculus

Salivary Gland Calculus

Salivary Stone

Salivary Duct Calculi

Sialodocholithiasis

Bile Duct Cystadenocarcinoma

Biliary Cystadenocarcinoma

Intrahepatic Bile Duct Cystadenocarcinoma

Intrahepatic Bile Duct Mucinous Cystic Neoplasm With An Associated Invasive Carcinoma

Enamel Erosion
Ethmoid Sinusitis

Ethmoidal Sinusitis

Ethmoiditis

Tooth Erosion

Generalized Erosion

Localized Erosion

Generalized Erosions

Erosion, Localized

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma