2. Gene
  3. MYO10 - myosin X Gene

MYO10 - myosin X Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肌球蛋白 X

种属: Homo sapiens

同用名: MyoX

基因 ID: 4651 | 基因类型: protein coding

关于 MYO10

Cytogenetic location: 5p15.1 Genomic coordinates (GRCh38): 5:16,661,907-16,936,288 (from NCBI)

This gene has 12 transcripts (splice variants), 195 orthologues and 43 paralogues. Broad expression in brain (RPKM 12.7), thyroid (RPKM 12.2) and 23 other tissues.

功能概要

该基因编码肌球蛋白超家族的一个成员。该蛋白质代表一种非常规的肌球蛋白；它不应与传统的非肌肉肌球蛋白 10 (MYH10) 混淆。非常规肌球蛋白包含常规肌球蛋白的基本结构域，并通过其尾部结构域进一步区别于类成员。该基因作为基于肌动蛋白的分子马达发挥作用，并在减数分裂过程中参与 F-肌动蛋白和微管细胞骨架的整合。[RefSeq 提供，2011 年 12 月]

This gene encodes a member of the Myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]

MYO10 基因产物(1)

mRNA Protein Name
NM_012334.3 NP_036466.2 unconventional myosin-X
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18570893 GOA
enables spectrin binding IDA
IDA: 通过直接分析推断
23704327 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of cell shape IMP
IMP: 通过突变表型推断
16894163 GOA
involved in regulation of filopodium assembly IMP
IMP: 通过突变表型推断
16894163 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MYO10 蛋白结构

Myosin_head

Myosin_head: Myosin head (motor domain) (65 - 727)

IQ

IQ: IQ calmodulin-binding motif (744 - 763)

IQ

IQ: IQ calmodulin-binding motif (768 - 785)

IQ

IQ: IQ calmodulin-binding motif (790 - 809)

PH

PH: PH domain (1215 - 1308)

PH

PH: PH domain (1395 - 1496)

MyTH4

MyTH4: MyTH4 domain (1584 - 1694)

FERM_M

FERM_M: FERM central domain (1798 - 1958)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2058 a.a.
蛋白主名 其他名称

unconventional myosin-X

unconventional myosin-10

MYO10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MYO10 Q9HD67 DCC Homo sapiens P43146
Anti Tag CoIP
21642953
种属内
MYO10 Q9HD67 CALML3 Homo sapiens P27482
Fluorescence Spectr
18570893
种属内
MYO10 Q9HD67 CALML3 Homo sapiens P27482
Pull Down
18570893
种属间
MYO10 Q9HD67 Dcc Rattus norvegicus Q63155
Pull Down
21321230
种属间
MYO10 Q9HD67 Dcc Rattus norvegicus Q63155
ITC
21321230
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Intellectual Developmental Disorder, Autosomal Dominant 44, With Microcephaly

MRD44

Micrognathia-Recurrent Infections-Behavioral Abnormalities-Mild Intellectual Disability Syndrome

Autosomal Dominant Non-Syndromic Intellectual Disability 44

Mental Retardation, Autosomal Dominant 44

Autosomal Dominant Intellectual Developmental Disorder 44

Autosomal Dominant Intellectual Developmental Disorder 44 With Microcephaly

Autosomal Dominant Mental Retardation 44

Mental Retardation, Autosomal Dominant, Type 44
Chondrocalcinosis

Pseudogout

Calcium Pyrophosphate Deposition Disease

Familial Chondrocalcinosis

Chondrocalcinosis Nos

Cppd - [Calcium Pyrophosphate Deposition Disease]

Cpdd - [Calcium Pyrophosphate Deposition Disease]

Chondrocalcinosis, Due To Pyrophosphate Crystals, Involving Unspecified Site

Chondrocalcinosis, Cause Unspecified

Chondrocalcinosis Due To Pyrophosphate Crystals

Chondrocalcinosis Articularis

Calcium Pyrophosphate Arthritis And Periarthritis
Anterior Segment Dysgenesis 5

Anterior Segment Dysgenesis 5, Multiple Subtypes

ASGD5

Dysgenesis, Anterior Segment, Type 5, Multiple Subtypes
Achondrogenesis, Type Ib

ACG1B

Achondrogenesis Type Ib

Achondrogenesis Type 1b

Achondrogenesis Ib

Achondrogenesis Fraccaro Type

Achondrogenesis, Fraccaro Type

Achondrogenesis, Parenti-Fraccaro Type

Achondrogenesis 1b

Acg-Ib

Fraccaro Achondrogenesis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08930 MYO10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus MYO10 VGNC VGNC:31811
Canis familiaris MYO10 VGNC VGNC:43554
Mus musculus MYO10 MGD MGI:107716
Rattus norvegicus MYO10 RGD RGD:1307193
Felis catus MYO10 VGNC VGNC:68387
Macaca mulatta MYO10 VGNC VGNC:75108
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